Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK?) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.

Abstract: A computer-implemented method is provided for anatomically indexing a subject. The method includes: receiving image scan data representing a volume of a subject, where the image scan data is comprised of a plurality of image slices of the subject and includes at least a portion of a vertebral column of the subject; identifying the vertebral canal of the vertebral column of the subject in the image scan data; determining a plurality of markers for the vertebral column, where each marker is indicative of a different vertebral body of the vertebral column and includes its location in the image scan data defined in a coordinate system, such that the plurality of markers define a vertebral level coordinate system; and storing each marker along with its location in a database. The markers can subsequently be used to reference other anatomical components of the subject across different image scans.

Abstract: A noninvasive, quantitative imaging technique is presented for detecting and diagnosing liver disease, such as cirrhosis. The technique includes: capturing scan data from a subject using computed tomography or another type of imaging method and extracting image data representing the liver from the scan data. Various measures of the liver may be obtained from image data and then used to compute random variables of a statistical model, where the model is predictive of a medical condition of the liver and comprised of random variables that are indicative of at least one of a shape or texture of the liver. Output from the statistical model provides an indication of an undesirable condition of the liver.

Abstract: A computer-implemented method is provided for anatomically indexing a subject. The method includes: receiving image scan data representing a volume of a subject, where the image scan data is comprised of a plurality of image slices of the subject and includes at least a portion of a vertebral column of the subject; identifying the vertebral canal of the vertebral column of the subject in the image scan data; determining a plurality of markers for the vertebral column, where each marker is indicative of a different vertebral body of the vertebral column and includes its location in the image scan data defined in a coordinate system, such that the plurality of markers define a vertebral level coordinate system; and storing each marker along with its location in a database. The markers can subsequently be used to reference other anatomical components of the subject across different image scans.

Abstract: A noninvasive, quantitative imaging technique is presented for detecting and diagnosing liver disease, such as cirrhosis. The technique includes: capturing scan data from a subject using computed tomography or another type of imaging method and extracting image data representing the liver from the scan data. Various measures of the liver may be obtained from image data and then used to compute random variables of a statistical model, where the model is predictive of a medical condition of the liver and comprised of random variables that are indicative of at least one of a shape or texture of the liver. Output from the statistical model provides an indication of an undesirable condition of the liver.

Abstract: A semiconductor device includes: a memory cell array that includes non-volatile memory cells; a first memory region and a second memory region that are located in the memory cell array, the first memory region being protected during a protecting period, the second memory region being not protected; an address change circuit that changes an address in an address space of the first memory region and the second memory region in the memory cell array, to an address in an address space of the second memory region, during the protecting period; and a control circuit that prohibits access to the first memory region, and allows access to the second region, during the protecting period.

Abstract: A semiconductor device includes: memory regions that include non-volatile memory cells; disabling information memory units that correspond to the memory regions, each of the disabling information memory units storing first program disabling information indicating whether programming is to be disabled or enabled in each corresponding memory region; a program disabling information selection circuit that outputs second program disabling information for disabling programming in a corresponding memory region, regardless of the first program disabling information, when programming is disabled collectively in the memory regions in accordance with collective program disabling information indicating whether programming is to be disabled collectively in the memory regions, the program disabling information selection circuit outputting the first program disabling information as the second program disabling information when programming is not collectively disabled; and a program control circuit that disables or enables p

Abstract: A semiconductor device includes: memory regions that include non-volatile memory cells; disabling information memory units that correspond to the memory regions, each of the disabling information memory units storing first program disabling information indicating whether programming is to be disabled or enabled in each corresponding memory region; a program disabling information selection circuit that outputs second program disabling information for disabling programming in a corresponding memory region, regardless of the first program disabling information, when programming is disabled collectively in the memory regions in accordance with collective program disabling information indicating whether programming is to be disabled collectively in the memory regions, the program disabling information selection circuit outputting the first program disabling information as the second program disabling information when programming is not collectively disabled; and a program control circuit that disables or enables p

Abstract: A semiconductor device includes: a memory cell array that includes non-volatile memory cells; a first memory region and a second memory region that are located in the memory cell array, the first memory region being protected during a protecting period, the second memory region being not protected; an address change circuit that changes an address in an address space of the first memory region and the second memory region in the memory cell array, to an address in an address space of the second memory region, during the protecting period; and a control circuit that prohibits access to the first memory region, and allows access to the second region, during the protecting period.