Patents by Inventor Stuart B. Levy

Stuart B. Levy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA
    Publication number: 20190040001
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Application
    Filed: February 20, 2018
    Publication date: February 7, 2019
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • TETRACYCLINE COMPOUNDS HAVING TARGET THERAPEUTIC ACTIVITIES
    Publication number: 20180016225
    Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
    Type: Application
    Filed: May 15, 2017
    Publication date: January 18, 2018
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Methods of using substituted tetracycline compounds to modulate RNA
    Patent number: 9562003
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: February 7, 2017
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA
    Publication number: 20150321997
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Application
    Filed: July 2, 2015
    Publication date: November 12, 2015
    Applicant: PARATEK PHARMACEUTICALS, INC.
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • TETRACYCLINE COMPOUNDS HAVING TARGET THERAPEUTIC ACTIVITIES
    Publication number: 20150141381
    Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
    Type: Application
    Filed: May 22, 2014
    Publication date: May 21, 2015
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA
    Publication number: 20140343020
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Application
    Filed: March 7, 2014
    Publication date: November 20, 2014
    Applicant: PARATEK PHARMACEUTICALS, INC
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • CRYSTAL STRUCTURE OF A MarR FAMILY POLYPEPTIDE
    Publication number: 20130144038
    Abstract: The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.
    Type: Application
    Filed: May 15, 2012
    Publication date: June 6, 2013
    Applicants: Trustees of Boston University, Trustees of Tufts College
    Inventors: Michael N. Alekshun, Stuart B. Levy, James F. Head, Barbara A. Seaton
  • Methods for treating spinal muscular atrophy using tetracycline compounds
    Patent number: 8399437
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: March 19, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Todd Bowser, Michael P. Draper, Stuart B. Levy, Mark L. Nelson
  • Methods of Using Substituted Tetracycline Compounds to Modulate RNA
    Publication number: 20120245130
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Application
    Filed: March 21, 2012
    Publication date: September 27, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael Draper, Mark L. Nelson, Graham Jones
  • METHODS FOR IDENTIFYING AND USING MarR FAMILY POLYPEPTIDE BINDING COMPOUNDS
    Publication number: 20120209003
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: September 9, 2011
    Publication date: August 16, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Methods of using substituted tetracycline compounds to modulate RNA
    Patent number: 8173624
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: May 8, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael Draper, Mark L. Nelson, Graham Jones
  • METHODS OF REDUCING MICROBIAL RESISTANCE TO DRUGS
    Publication number: 20110301127
    Abstract: The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.
    Type: Application
    Filed: August 16, 2011
    Publication date: December 8, 2011
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Margret OETHINGER, Stuart B. LEVY
  • Methods for identifying and using MarR family polypeptide binding compounds
    Patent number: 8039221
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: October 18, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • MARA FAMILY HELIX-TURN-HELIX DOMAINS AND THEIR METHODS OF USE
    Publication number: 20110251095
    Abstract: An important advance in the battle against drug resistance by elucidating the domains of MarA which are critical in mediating its function. Accordingly, MarA family protein helix-turn-helix domains, mutant MarA family protein helix-turn-helix domains and methods of their use, for example, in screening assays to identify compounds which are useful as antiinfective agents and in screening assays to identify loci which are involved in mediating antibiotic resistance are described.
    Type: Application
    Filed: May 9, 2011
    Publication date: October 13, 2011
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventor: Stuart B. Levy
  • TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20110230523
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: August 6, 2009
    Publication date: September 22, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. LEVY, Michael N. ALEKSHUN, Brent L. PODLOGAR, Kwasi OHEMENG, Atul K. VERMA, Tadeusz WARCHOL, Beena BHATIA, Todd BOWSER, Mark GRIER
  • Methods of screening for compounds that reduce microbial resistance to fluoroquinolones
    Patent number: 8012711
    Abstract: The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: September 6, 2011
    Assignee: Trustees of Tufts College
    Inventors: Margret Oethinger, Stuart B. Levy
  • Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds
    Publication number: 20110207706
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Application
    Filed: May 3, 2011
    Publication date: August 25, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Todd Bowser, Michael Draper, Stuart B. Levy, Mark L. Nelson
  • Methods for treating spinal muscular atrophy using tetracycline compounds
    Patent number: 7935687
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: May 3, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Todd Bowser, Michael Draper, Stuart B. Levy, Mark L. Nelson
  • 7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds
    Publication number: 20110092467
    Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
    Type: Application
    Filed: December 22, 2010
    Publication date: April 21, 2011
    Applicants: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd Bowser, Mohamed Y. Ismail
  • Tetracycline Compounds for Treatment of Cryptosporidium Parvum Related Disorders
    Publication number: 20110086821
    Abstract: Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included.
    Type: Application
    Filed: October 4, 2010
    Publication date: April 14, 2011
    Applicant: Trustees of Tufts College
    Inventors: Stuart B. Levy, Mark L. Nelson