Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: A bolt restraint mechanism for restraining a bolt of a bolting mechanism. The bolt restraint mechanism includes a bolt moveable between thrown and retracted positions and a catch plate having an aperture through which the bolt extends. The catch plate is biased to pivot such that a restraint surface of the aperture pushes against the bolt to restrain movement of the bolt. A release trigger is arranged such that when depressed the release trigger pushes against the catch plate to pivot thereby releasing the restraint surface from pushing against the bolt to release the bolt. The catch plate may be biased such that when the restraint surface pushes against the bolt to restrain movement of the bolt, the catch plate is non-orthogonal to the bolt.

Abstract: A driver, e.g., a UEFI driver (140), for a device (120) in a host (110) starts before an OS boot. The driver (140) provides functions including gathering information regarding the host system (110), directing the device (120) to transmit the gathered information to a cloud-based service (182), directing the device (120) to provide a catalog of current firmware, updating firmware in the host (110) or device (120) based on the catalog, and configuring the device (120). The device may be a storage processing unit (120) that is part of a cluster (100) that presents virtual volumes including a boot volume (138) for the host (110), and execution of the driver (140) can provide a delay until a boot volume (138) is ready.

Abstract: A system and method for characterising a narrowing in a fluid filled tube, the system comprising: a probe having a first measurement sensor to take an instantaneous measurement at different locations along the tube; a mechanism to draw the probe through the tube; a position measure to provide location data relating to the location at which a respective instantaneous measurement is taken by the first measurement sensor; a processor to calculate, from the instantaneous measurements, a characteristic of the tube at different locations along the tube.

Abstract: A system and method for characterising a narrowing in a fluid filled tube, the system comprising: a probe having a first measurement sensor to take an instantaneous measurement at different locations along the tube; a mechanism to draw the probe through the tube; a position measure to provide location data relating to the location at which a respective instantaneous measurement is taken by the first measurement sensor; a processor to calculate, from the instantaneous measurements, a characteristic of the tube at different locations along the tube.

Abstract: A system and method for characterising a narrowing in a fluid filled tube, the system comprising: a probe having a first measurement sensor to take an instantaneous measurement at different locations along the tube; a mechanism to draw the probe through the tube; a position measure to provide location data relating to the location at which a respective instantaneous measurement is taken by the first measurement sensor; a processor to calculate, from the instantaneous measurements, a characteristic of the tube at different locations along the tube.

Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent.

Abstract: A method of manufacturing a three-dimensional object includes: providing a carrier which has a predetermined surface including a first surface, a second surface, and a third surface; and driving a discharging head to move on a work track and conduct a three-dimensional spread corresponding to the first surface, the second surface, and the third surface, wherein the predetermined surface and the work track have an identical spacing therebetween. Wherein the discharging head moves relative to the first surface using a first movement speed and conducts the three-dimensional spread, the discharging head moves relative to the second surface using a second movement speed and conducts the three-dimensional spread, the discharging head moves relative to the third surface using a third movement speed and conducts the three-dimensional spread.

Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent.

Abstract: A method of manufacturing a three-dimensional object includes: providing a carrier which has a predetermined surface including a first surface, a second surface, and a third surface; and driving a discharging head to move on a work track and conduct a three-dimensional spread corresponding to the first surface, the second surface, and the third surface, wherein the predetermined surface and the work track have an identical spacing therebetween. Wherein the discharging head moves relative to the first surface using a first movement speed and conducts the three-dimensional spread, the discharging head moves relative to the second surface using a second movement speed and conducts the three-dimensional spread, the discharging head moves relative to the third surface using a third movement speed and conducts the three-dimensional spread.

Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent.

Abstract: A housing includes a 3-D composite structure. The structure includes a flex foil. An antenna trace is provided on a first surface of the flex foil. A shield, which may be a sheet, is positioned on the antenna trace. A resin is molded to the first surface, the shield and the antenna trace. The resultant structure allows for a thin-walled design that can communicate efficiently via wireless signals.

Abstract: A system and method for characterising a narrowing in a fluid filled tube, the system comprising: a probe having a first measurement sensor to take an instantaneous measurement at different locations along the tube; a mechanism to draw the probe through the tube; a position measure to provide location data relating to the location at which a respective instantaneous measurement is taken by the first measurement sensor; a processor to calculate, from the instantaneous measurements, a characteristic of the tube at different locations along the tube.

Abstract: A housing includes a 3-D composite structure. The structure includes a flex foil. An antenna trace is provided on a first surface of the flex foil. A shield, which may be a sheet, is positioned on the antenna trace. A resin is molded to the first surface, the shield and the antenna trace. The resultant structure allows for a thin-walled design that can communicate efficiently via wireless signals.

Abstract: An apparatus for providing a virtual reality sexual experience. The apparatus including audio reproduction means, visual reproduction means and tactile means for sexual stimulation. The apparatus further comprising a control system to correlate the audio means, visual means and tactile means to relate to one another to simulate a sexual experience. The apparatus being adapted for connection to a computer based drive system to provide a scenario for audio and visual outputs which is selected from a database and advances in a manner corresponding to user movements and engagement with the tactile system.