Patents by Inventor Stuart Geoffrey Dashper
Stuart Geoffrey Dashper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8916166Abstract: The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.Type: GrantFiled: July 12, 2012Date of Patent: December 23, 2014Assignee: Oral Health Australia Pty LtdInventors: Stuart Geoffrey Dashper, Ching Seng Ang, Paul David Veith, Eric Charles Reynolds
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Patent number: 8911745Abstract: The invention provides a composition for use in raising an immune response to P. gingivalis in a subject, the composition comprising an amount effective to raise an immune response of at least one polypeptide having an amino acid sequence substantially identical to at least 50 amino acids, or an antigenic or immunogenic portion, of one of the polypeptides corresponding to accession numbers selected from the group consisting of AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. The invention also provides a method of preventing or treating a subject for P. gingivalis infection comprising administering to the subject a composition of the invention.Type: GrantFiled: September 20, 2012Date of Patent: December 16, 2014Assignee: Oral Health Australia Pty Ltd.Inventors: Stuart Geoffrey Dashper, Eric Charles Reynolds, Paul David Veith, Ching Seng Ang
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Patent number: 8895019Abstract: The invention provides a method of preventing, inhibiting or reducing a P. gingivalis biofilm in a subject comprising administering to the subject a pharmaceutical composition comprising an inhibiting agent of a polypeptide that reduces or inhibits biofilm formation and/or biofilm development. Also provided are compositions useful in the prevention, inhibition or treatment of periodontal disease or P. gingivalis infection.Type: GrantFiled: July 13, 2012Date of Patent: November 25, 2014Assignee: Oral Health Australia Pty LtdInventors: Stuart Geoffrey Dashper, Eric Charles Reynolds, Paul David Veith, Ching Seng Ang
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Publication number: 20140288007Abstract: The disclosure relates to compounds, peptides or peptidomimetics that inhibit, reduce or prevent protease activity and the use of these compounds, peptides or peptidomimetics to treat or prevent a condition. In particular the condition may be periodontal disease. The protease activity may be activity of a gingipain. The compounds, peptides or peptidomimetics of the invention may also be used in assays for the identification of protease inhibitors.Type: ApplicationFiled: November 2, 2012Publication date: September 25, 2014Applicant: Oral Health Australia Pty. Ltd.Inventors: Stuart Geoffrey Dashper, Eric Charles Reynolds, Noorjahan Laila Huq, Elena Chiew Yeen Toh
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Publication number: 20130236488Abstract: The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.Type: ApplicationFiled: July 12, 2012Publication date: September 12, 2013Inventors: Stuart Geoffrey Dashper, Ching Seng Ang, Paul David Veith, Eric Charles Reynolds
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Publication number: 20130028847Abstract: The invention provides a method of preventing, inhibiting or reducing a P. gingivalis biofilm in a subject comprising administering to the subject a pharmaceutical composition comprising an inhibiting agent of a polypeptide that reduces or inhibits biofilm formation and/or biofilm development. Also provided are compositions useful in the prevention, inhibition or treatment of periodontal disease or P. gingivalis infection.Type: ApplicationFiled: July 13, 2012Publication date: January 31, 2013Inventors: Stuart Geoffrey Dashper, Eric Charles Reynolds, Paul David Veith, Ching Seng Ang
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Publication number: 20120283174Abstract: The present invention relates to peptides and compositions that have antibiofilm properties. In particular, the peptides and compositions of the invention can be used for the treatment or prevention of various conditions including dental caries, gingivitis, periodontitis, oral mucositis, dry mouth and xerostomia.Type: ApplicationFiled: November 11, 2010Publication date: November 8, 2012Applicant: ORAL HEALTH AUSTRALIA PTY. LTD.Inventors: Eric Charles Reynolds, Stuart Geoffrey Dashper
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Patent number: 8241611Abstract: The invention provides a method of preventing, inhibiting or reducing a P. gingivalis biofilm in a subject comprising administering to the subject a pharmaceutical composition comprising an inhibiting agent of a polypeptide that reduces or inhibits biofilm formation and/or biofilm development. Also provided are compositions useful in the prevention, inhibition or treatment of periodontal disease or P. gingivalis infection.Type: GrantFiled: July 11, 2008Date of Patent: August 14, 2012Assignee: Oral Health Austrailia Pty. Ltd.Inventors: Stuart Geoffrey Dashper, Eric Charles Reynolds, Paul David Veith, Ching Seng Ang
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Patent number: 8106152Abstract: The present invention relates to novel antimicrobial composition comprising a peptide which can be obtained from the milk protein casein or chemically synthesised or produced by recombinant DNA technology and a divalent cation.Type: GrantFiled: December 15, 2004Date of Patent: January 31, 2012Assignee: Dairy Australia LimitedInventors: Eric Charles Reynolds, Stuart Geoffrey Dashper, Rita Ann Paolini
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Publication number: 20110104179Abstract: The present invention relates to compounds, peptides, peptidomimetics and pharmaceutical compositions that inhibit protease activity, and the use of these compounds, peptides, peptidomimetics and pharmaceutical compositions comprising them to treat or prevent a condition. In particular the condition may be periodontal disease. The compounds, peptides and peptidomimetics may be obtained from various caseins, for example ?-casein, ?-casein and ?-casein. The protease activity which the compounds, peptides, peptidomimetics and pharmaceutical compositions of the invention inhibit includes that of the gingipains.Type: ApplicationFiled: June 18, 2010Publication date: May 5, 2011Inventors: Eric Charles Reynolds, Stuart Geoffrey Dashper
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Publication number: 20100297179Abstract: The invention provides a composition for use in raising an immune response to P. gingivalis in a subject, the composition comprising an amount effective to raise an immune response of at least one polypeptide having an amino acid sequence substantially identical to at least 50 amino acids, or an antigenic or immunogenic portion, of one of the polypeptides corresponding to accession numbers selected from the group consisting of AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. The invention also provides a method of preventing or treating a subject for P.Type: ApplicationFiled: July 11, 2008Publication date: November 25, 2010Inventors: Stuart Geoffrey Dashper, Eric Charles Reynolds, Paul David Veith, Ching Seng Ang
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Publication number: 20100209362Abstract: The invention provides a method of preventing, inhibiting or reducing a P. gingivalis biofilm in a subject comprising administering to the subject a pharmaceutical composition comprising an inhibiting agent of a polypeptide that reduces or inhibits biofilm formation and/or biofilm development. Also provided are compositions useful in the prevention, inhibition or treatment of periodontal disease or P. gingivalis infection.Type: ApplicationFiled: July 11, 2008Publication date: August 19, 2010Inventors: Stuart Geoffrey Dashper, Eric Charles Reynolds, Paul David Veith, Ching Seng Ang
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Publication number: 20100092471Abstract: The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.Type: ApplicationFiled: June 27, 2007Publication date: April 15, 2010Applicant: ORAL HEALTH AUSTRALIA PTY LTDInventors: Stuart Geoffrey Dashper, Ching Seng Ang, Paul David Veith, Eric Charles Reynolds
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Publication number: 20090246150Abstract: The present invention relates to novel antimicrobial composition comprising a peptide which can be obtained from the milk protein casein or chemically synthesised or produced by recombinant DNA technology and a divalent cation.Type: ApplicationFiled: December 15, 2004Publication date: October 1, 2009Inventors: Eric Charles Reynolds, Stuart Geoffrey Dashper, Rita Ann Paolini
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Publication number: 20030195150Abstract: The present invention provides antimicrobial peptides. The peptides are non-glycosylated, less than about 100 amino acids in length, and include an amino acid sequence selected from: AVESTVATLEA&Sgr;PEVIESPPE (SEQ ID NO:3), AVESTVATLED&Sgr;PEVIESPPE (SEQ ID NO:4), AVESTVATLEASPEVIESPPE (SEQ ID NO:5), AVESTVATLEDSPEVIESPPE (SEQ ID NO:6), DMPIQAFLLYQQPVLGPVR (SEQ ID NO:7), and conservative substitutions therein. These peptides can be produced synthetically; however, they can most conveniently be derived from casein.Type: ApplicationFiled: October 24, 2002Publication date: October 16, 2003Inventors: Eric Charles Reynolds, Stuart Geoffrey Dashper, Neil Martin O'Brien-Simpson, Gert Hoy Talbo, Marina Malkoski