Abstract: The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator comprising: i) an outer body defining a top of the actuator, the outer body containing a cavity; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) the porator array comprising: i) a top surface, with a removable adhesive attached to the top surface, the top surface containing two concentric electrical contact rings for contacting the interface connection port at the anode and the cathode upon removal of the adhesive layer; ii) a bottom surface comprising a tissue interface membrane, the tissue interface membrane further comprising a substrate with at least one porator contained on or within the substrate, the bottom surface further comprising an adhesive layer for a

Abstract: Disclosed is a device for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii)an undissolved hydrophilic per meant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic per meant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject.

Abstract: A transdermal drug delivery device for forming a micropore in a tissue membrane of an animal comprising a substrate and a porator that is located on or within the substrate. The porator is constructed of a material that is destroyed upon forming the micropore. The transdermal drug delivery device also comprises at least one reservoir and a controller for controlling the formation of said micropore by the porator and destroying the porator after the formation of the micropore.

Abstract: A system and method for detecting a measuring an analyte in a biological fluid of an animal. A harvesting device (10) is provided suitable for positioning on the surface of tissue of an animal to harvest biological fluid therefrom. The harvesting device (10) comprises an analyte sensor (50) positioned to be contacted by the harvested biological fluid and which generates a measurement signal representative of the analyte. At least one attribute sensor (40) is provided to measure an attribute associated with the biological fluid harvesting operation of the harvesting device (10) or the assay of the biological fluid, and which generates an attribute signal representative of the attribute. Adjustments are made to operational parameters of the harvesting device (10) based on the one or more attributes.

Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.

Abstract: The invention provides for a transdermal drug delivery device for forming a micropore in a tissue membrane of an animal, comprising:

Abstract: The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising:

Abstract: A device to facilitate ablation of tissue, such as for forming one or more openings in the tissue for transdermal monitoring and/or delivery applications. The device comprises: (a) a support layer having at least one aperture therein, and (b) at least one energy absorbent film layer disposed over the at least one aperture in the support layer for making substantial contact with tissue through the aperture. The at least one energy absorbent film layer is under a tension force and absorbs energy focused thereon to thermally ablate the tissue. After ablation, the layer breaks apart allowing access to the ablated tissue beneath it.

Abstract: The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: