Abstract: A target polynucleotide is expanded. In respect of each nucleotide in the target polynucleotide, the target polynucleotide comprises clock nucleotides and at least one signal nucleotide in a predetermined order. The clock nucleotides have a predetermined sequence common to each nucleotide in the target polynucleotide. The at least one signal nucleotide is characteristic of the identity of the respective nucleotide in the target polynucleotide. During translocation of the expanded polynucleotide through a nanopore, electrical measurements dependent on the polynucleotide within the pore are made, to derive an analysis signal. Clock signals derived from the clock nucleotides are identified. Relative to the positions of the identified clock signals, nucleotide signals derived from the least one signal nucleotide are derived to analyse the target polynucleotide.

Abstract: An electrophysiology catheter with a distal electrode assembly having covered spine carrying a plurality of microelectrodes. The spines have nonconductive covers that are reinforced with tensile members, e.g., wires or fibers, that extend (or have portions that extend) longitudinally so as to minimize any elongation of the covers and the microelectrodes carried thereon. The tensile members may also have a length greater than the length of the spines so the proximal portions extend proximally from the spines, through the catheter and at least into the control handle for actuation by an operator for deflecting and moving the spines, like “fingers.

Abstract: A method of dynamically allocating a total amount of produced water (PW) from a reservoir during enhanced oil recovery (EOR) via a low salinity or softened water EOR flood by receiving measurement data; receiving reservoir configuration information comprising: an EOR injection rate associated with one or more EOR injection zones, a disposal zone injection rate associated with one or more disposal injection zones, and a non-reinjection disposal rate associated with one or more non-reinjection disposal routes; determining a blending rate comprising at least a portion of the PW production rate and at least a portion of the low salinity or softened water injection rate to provide a blended injection fluid; blending at least a portion of the PW with at least a portion of the low salinity or softened water at the blending rate; and dynamically allocating the PW production rate among injection and/or non-reinjection routes.

Abstract: An electrophysiology catheter with a distal electrode assembly having covered spine carrying a plurality of microelectrodes. One or more spines have preformed configurations including at least a first portion with a first curvature and a second portion with a second curvature, and may include a linear portion. The linear portion may be between the first and second portions. The linear portion may be distal of the first and second portions. One or more spines have a narrower portion so that different portions of the spine can have different flexibility with a degree of independence in flexibility from adjacent portions.

Abstract: In one aspect, a system for obtaining dielectric properties of an object is disclosed, which comprises a plurality of transceivers for generating radiation in the microwave or millimeter-wave region of the electromagnetic spectrum. The transceivers are positioned in spatially fixed relationships relative to one another. The system further includes a controller for selectively activating the transceivers for irradiating at least a portion of the object and detecting at least a portion of the radiation reflected from said portion of the object in response to the irradiation, where each of the activated transceivers generates a signal in response to detection of the reflected radiation. The reflected signals are analyzed to determine a plurality of reflectivity coefficients corresponding to different discrete locations of the object, and the reflectivity coefficients are used to determine the complex permittivity of the discrete locations.

Abstract: A catheter with basket-shaped electrode assembly with spines configured for hyper-flexing in a predetermined, predictable manner when a compressive force acts on the assembly from either its distal end or its proximal end. At least one spine has at least one region of greater (or hyper) flexibility that allows the electrode assembly to deform, for example, compress, for absorbing and dampening excessive force that may otherwise cause damage or injury to tissue wall in contact with the assembly, without compromising the structure and stiffness of the remaining regions of the spine, including its distal and proximal regions. The one or more regions of greater flexibility in the spine allow the spine to flex into a generally V-shape configuration or a generally U-shape configuration.

Abstract: A biochemical analysis system analyses polymers by taking measurements of a polymer from a sensor element comprising a nanopore during translocation of the polymer through the nanopore. When a polymer has partially translocated, the series of measurements is analysed using reference data derived from a reference sequence to provide a measure of similarity. Responsive to the measure of similarity, the sensor element may be selectively operated to eject the polymer and thereby make the nanopore available to receive a further polymer. Where the biochemical analysis system comprises an array of sensor elements and is takes measurements from sensor elements selected in a multiplexed manner, responsive to the measure of similarity, the biochemical analysis system ceases taking measurements from the currently selected sensor element and to starts taking measurements from a newly selected sensor element.

Abstract: In one aspect, a system for obtaining dielectric properties of an object is disclosed, which comprises a plurality of transceivers for generating radiation in the microwave or millimeter-wave region of the electromagnetic spectrum. The transceivers are positioned in spatially fixed relationships relative to one another. The system further includes a controller for selectively activating the transceivers for irradiating at least a portion of the object and detecting at least a portion of the radiation reflected from said portion of the object in response to the irradiation, where each of the activated transceivers generates a signal in response to detection of the reflected radiation. The reflected signals are analyzed to determine a plurality of reflectivity coefficients corresponding to different discrete locations of the object, and the reflectivity coefficients are used to determine the complex permittivity of the discrete locations.

Abstract: In one aspect, a system for obtaining dielectric properties of an object is disclosed, which comprises a plurality of transceivers for generating radiation in the microwave or millimeter-wave region of the electromagnetic spectrum. The transceivers are positioned in spatially fixed relationships relative to one another. The system further includes a controller for selectively activating the transceivers for irradiating at least a portion of the object and detecting at least a portion of the radiation reflected from said portion of the object in response to the irradiation, where each of the activated transceivers generates a signal in response to detection of the reflected radiation. The reflected signals are analyzed to determine a plurality of reflectivity coefficients corresponding to different discrete locations of the object, and the reflectivity coefficients are used to determine the complex permittivity of the discrete locations.

Abstract: The present invention generally relates to the treatment of ulcerative colitis with an anti-IL-23p19 antibody, in particular dosage regimens for the treatment of the disease.

Abstract: An electrophysiology catheter with a distal electrode assembly having covered spine carrying a plurality of microelectrodes. The spines have nonconductive covers that are reinforced with tensile members, e.g., wires or fibers, that extend (or have portions that extend) longitudinally so as to minimize any elongation of the covers and the microelectrodes carried thereon. The tensile members may also have a length greater than the length of the spines so the proximal portions extend proximally from the spines, through the catheter and at least into the control handle for actuation by an operator for deflecting and moving the spines, like “fingers.

Abstract: An electrophysiology catheter with a distal electrode assembly having covered spine carrying a plurality of microelectrodes. One or more spines have preformed configurations including at least a first portion with a first curvature and a second portion with a second curvature, and may include a linear portion. The linear portion may be between the first and second portions. The linear portion may be distal of the first and second portions. One or more spines have a narrower portion so that different portions of the spine can have different flexibility with a degree of independence in flexibility from adjacent portions.

Abstract: Systems, methods, and machine-readable media are provided for processing items within an automated storage and retrieval device. A scanned machine-readable identifier associated with an item is received at an automated storage and retrieval device. A determination is made whether the machine-readable identifier that was scanned is a container identification (ID). The machine-readable identifier is identified based on pre-defined criteria when the machine-readable identifier is determined not to be a container ID. The machine-readable identifier is mapped to an existing order using stored order information. A container ID is created by the fulfillment system and passed back to the automated storage and retrieval device. The item is stored in the automated storage and retrieval device using the created container ID.

Abstract: An animal trap includes: a bait, a support, and an elastic band, wherein in a set state the support supports the elastic band in an expanded state, and wherein removal, consumption or destruction of the bait by an animal: causes the elastic band to contract around the animal to kill the animal; or causes the elastic band to drive a kill mechanism to kill the animal. Animal traps may be formed substantially or entirely of biodegradable materials. Animal traps may be adapted for aerial distribution. A trap dispenser may dispense traps as they are triggered.

Abstract: A data analysis platform may be based on database views. A build module may receive, from a source code repository, information about a modified definition of a view. The build module may identify schema objects on which the view depends and form instructions for creating the view and the schema objects. The instructions may be executed to form the updated version of the view in a schema space separate from a production schema space. A deployment pipeline may coordinate replacing the production version of the view with the new version in response to validating the new version of the view.

Abstract: An animal trap includes: a bait, a support, and an elastic band, wherein in a set state the support supports the elastic band in an expanded state, and wherein removal, consumption or destruction of the bait by an animal: causes the elastic band to contract around the animal to kill the animal; or causes the elastic band to drive a kill mechanism to kill the animal. Animal traps may be formed substantially or entirely of biodegradable materials. Animal traps may be adapted for aerial distribution. A trap dispenser may dispense traps as they are triggered.

Abstract: This disclosure is directed to a catheter having a basket-shaped electrode assembly with a high electrode density. The basket-shaped electrode assembly may have a plurality of spines, such as up to twelve, each with a plurality of electrodes, such as up to sixteen. The distal ends of the plurality of spines are joined at a distal hub, all of which are fashioned from a single piece of superelastic material.

Abstract: A system for troubleshooting signals in a cellular communications network, and in particular, for determining the cause of distortion or corruption of such signals, includes a robotic or other type of switch. The robotic switch can tap into selected uplink fiber-optic lines and selected downlink fiber-optic lines between radio equipment and radio equipment controllers in a wireless (e.g., cellular) network to extract therefrom the I and Q data. The selected I and Q data, in an optical form, is provided to an optical-to-electrical converter forming part of the system. The system includes an FPGA (Field Programmable Gate Array) or the like, and an analytic computer unit, or web server, and SSD (Solid State Drive) and magnetic disk storage, among other components of the system. The system analyzes the I and Q data provided to it, and determines the cause, or at least narrows the field of possible causes, of impairment to transmitted signals.

Abstract: A catheter adapted or high density mapping and/or ablation of tissue surface has a distal electrode matrix having a plurality of spines arranged in parallel configuration on which a multitude of electrodes are carried in a grid formation for providing uniformity and predictability in electrode placement on the tissue surface. The matrix can be dragged against the tissue surface upon deflection (and/or release of the deflection) of the catheter. The spines generally maintain their parallel configuration and the multitude of electrodes generally maintain their predetermined relative spacing in the grid formation as the matrix is dragged across the tissue surface in providing very high density mapping signals. The spines may have free distal ends, or distal ends that are joined to form loops for maintaining the spines in parallel configuration.

Abstract: The disclosure teaches precisely engineered biodegradable drug delivery systems and methods of making and utilizing such systems. In aspects, the biodegradable drug delivery systems taught herein comprise intravitreal ocular implants suitable for delivery of corticosteroids to the posterior segment of a human eye. The intravitreal ocular implants described herein have a desired extended drug release profile suitable for treating inflammation of the human eye.