Abstract: A system and a method for renal replacement therapy includes a blood treatment unit connected to a blood circuit and a dialysis fluid circuit, the system further including a control unit configured to control the system according to control instructions during a treatment, so as to determine a system parameter value and an indication of membrane fouling of the membrane, and activate an automatic anti-fouling measure that includes a temporary change of the flow rate in the blood circuit and a temporary decrease of the ultrafiltration rate wherein a timing of the temporary change and a timing of the temporary reduction are synchronized.

Abstract: An extracorporeal therapy system includes: (i) a dialysis fluid circuit including dialysis fluid preparation structure to prepare a dialysis fluid for treatment, the dialysis fluid circuit including a fresh dialysis fluid pump, a used dialysis fluid pump, and at least one filter for purifying the dialysis fluid; (ii) a blood circuit including a blood filter for use during the treatment; (iii) a blood pump operable to pump blood through the blood circuit and blood filter; (iv) a source of disinfecting fluid; and (v) a control unit operable with the dialysis fluid preparation structure and the blood pump, the control unit programmed to cause the disinfecting fluid to be delivered to and located for a duration at an area of the dialysis fluid circuit having the at least one purifying filter, and wherein during the duration the disinfecting fluid is precluded from contacting at least the fresh dialysis fluid pump.

Abstract: A dialysis machine configured to carry out a method and a method for draining an extracorporeal fluid circuit utilizing a dialysis machine, wherein the dialysis machine is connected to a dialyzer and said extracorporeal fluid circuit, said extracorporeal fluid circuit comprising an arterial line connectable to a patient, for drawing blood from the patient and a venous line connectable to the patient for returning blood to the patient, the method comprising: after treatment termination from said extracorporeal fluid circuit draining remaining fluid from said extracorporeal fluid circuit through the dialyzer.

Abstract: Dialysis machines comprising a feed arrangement to supply a dialysis fluid to a dialyzer during dialysis treatment and a return arrangement to remove the dialysis fluid from the dialyzer during dialysis treatment and forward it to an exit; a feed recirculation circuit to allow a fluid of the feed arrangement to be re-circulated in a fluid loop path comprising, at least a portion of, the feed arrangement and the feed recirculation circuit and a return recirculation circuit to allow a fluid of the return arrangement to re-circulate in an auxiliary fluid loop path comprising, at least a portion of, the return arrangement and the return recirculation circuit. A controller configured to perform disinfection by re-circulating a disinfectant and/or a heated fluid through said fluid loop path and/or through said auxiliary fluid loop path.

Abstract: A renal failure therapy system includes a dialysis fluid circuit including a dialysis fluid pump; a source of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer in operable communication with the dialysis fluid pump, the logic implementer causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source to be added to purified water from the purified water source to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit without a subsequent rinse.

Abstract: A renal failure therapy system having an electrically floating fluid pathway is disclosed. The example system includes a dialyzer, a blood circuit in fluid communication with the dialyzer, and a dialysis fluid circuit in fluid communication with the dialyzer. The system also includes an electrically floating fluid pathway comprising at least a portion of the blood circuit and at least a portion of the dialysis fluid circuit. The only electrical path to ground is via used dialysis fluid traveling through the renal failure therapy system to earth ground. The disclosed system enables at least one electrical component in the at least a portion of the dialysis fluid circuit of the electrically floating fluid pathway to be electrically bypassed.

Abstract: A medical device system includes renal failure therapy machines each including a memory. The renal failure therapy machines are communicatively coupled such that the memories collectively form a distributed database. The system also includes a logic implementer associated with each renal failure therapy machine. Each logic implementer is programmed to automatically access the distributed database, so that each renal failure therapy machine periodically delivers prescription input parameters and/or treatment output data to at least one of the other renal failure therapy machines, and retrieves prescription input parameters and/or treatment output data from at least one of the other renal failure therapy machines. One of the renal failure therapy machines is configured to create at least one treatment record trend from the treatment output data and to share the at least one treatment record trend with other renal failure therapy machines through the distributed database.

Abstract: Dialysis machines comprising a feed arrangement to supply a dialysis fluid to a dialyzer during dialysis treatment and a return arrangement to remove the dialysis fluid from the dialyzer during dialysis treatment and forward it to an exit; a feed recirculation circuit to allow a fluid of the feed arrangement to be re-circulated in a fluid loop path comprising, at least a portion of, the feed arrangement and the feed recirculation circuit and a return recirculation circuit to allow a fluid of the return arrangement to re-circulate in an auxiliary fluid loop path comprising, at least a portion of, the return arrangement and the return recirculation circuit. A controller configured to perform disinfection by re-circulating a disinfectant and/or a heated fluid through said fluid loop path and/or through said auxiliary fluid loop path.

Abstract: A medical device system (10) including a distributed database (10a to 10f); a plurality of medical devices (12) operating with the distributed database (10a to 10f); and a logic implementer (20) associated with each medical device (12), wherein each logic implementer (20) is programmed to access the distributed database (10a to 10f), so that each medical device (12) of system (10) periodically (i) delivers at least one of prescription input parameters or treatment output data to and (ii) retrieves at least one of prescription input parameters or treatment output data from each of the other medical devices (12).

Abstract: Systems and apparatuses for preparing a medical fluid are disclosed. In an example embodiment, a system is configured to initially control a dosing of a first concentrate, while not feeding a second concentrate, under feedback control via a concentration sensor to a first pump to feed the first concentrate. When a concentration has reached a preselected concentration level, a value for a feeding parameter for the first pump to feed the first concentrate is determined. Additionally, the system is configured to control the dosing of both the first and the second concentrates by switching the feedback control via the concentration sensor, from control of the first pump to control of a second pump to feed the second concentrate. During this time, the system controls the first pump to feed the first concentrate based on the determined value of the feeding parameter.

Abstract: Dialysis machines comprising a feed arrangement (170) to supply a dialysis fluid to a dialyzer (150) during dialysis treatment and a return arrangement (171) to remove the dialysis fluid from the dialyzer during dialysis treatment and forward it to an exit (129); a feed recirculation circuit (172) to allow a fluid of the feed arrangement to be re-circulated in a fluid loop path comprising, at least a portion of, the feed arrangement and the feed recirculation circuit and a return recirculation circuit (173) to allow a fluid of the return arrangement to re-circulate in an auxiliary fluid loop path comprising, at least a portion of, the return arrangement and the return recirculation circuit. A controller (160) configured to perform disinfection by re-circulating a disinfectant and/or a heated fluid through said fluid loop path and/or through said auxiliary fluid loop path.

Abstract: A monitoring device operates to monitor regional citrate anticoagulation (RCA) in a blood treatment system which is configured to administrate citrate to an extracorporeal blood circuit (10) upstream of a dialyzer (11) during a treatment session. At consecutive time steps during the treatment session, the monitoring device obtains a current measurement value of systemic ionized calcium (iCaSYS) or systemic total calcium (CaSYS), operates a predefined algorithm on the current measurement value to generate a current computation value that represents ionized calcium (iCa2, iCa3) in blood at a selected location (loc2, loc3) downstream or upstream of the dialyzer (11) in the extracorporeal blood circuit (10), and presents and/or evaluates the current computation value for assessment of the regional citrate anticoagulation. The need for conventional blood sampling and blood analysis upstream and/or downstream of the dialyzer, e.g. during CRRT, is thereby reduced significantly.

Abstract: A renal failure therapy system having an electrically floating fluid pathway is disclosed. The example system includes a dialyzer, a blood circuit in fluid communication with the dialyzer, and a dialysis fluid circuit in fluid communication with the dialyzer. The system also includes an electrically floating fluid pathway comprising at least a portion of the blood circuit and at least a portion of the dialysis fluid circuit. The only electrical path to ground is via used dialysis fluid traveling through the renal failure therapy system to earth ground. The disclosed system enables at least one electrical component in the at least a portion of the dialysis fluid circuit of the electrically floating fluid pathway to be electrically bypassed.

Abstract: A renal failure therapy system includes a dialysis fluid circuit including a dialysis fluid pump; a source of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer in operable communication with the dialysis fluid pump, the logic implementer causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source to be added to purified water from the purified water source to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit without a subsequent rinse.

Abstract: In an embodiment, a dialysis machine includes a dialyser, a fluid line in fluid communication with the dialyser, an inlet valve enabling fluid to flow into the fluid line towards the dialyser during a dialysis treatment, a disinfectant line connected to the fluid line via a disinfectant valve upstream of the dialyser, the disinfectant valve enabling a disinfectant fluid to be provided to at least part of the fluid line during a disinfection procedure, and a controller programmed to open the inlet valve, while the disinfectant line is connected to a source of disinfectant fluid, to create a positive pressure gradient across the disinfectant valve as fluid flows into the fluid line towards the dialyser, the positive pressure gradient ensuring that the disinfectant fluid from the source of disinfectant fluid does not leak into the fluid line during the dialysis treatment.

Abstract: A renal failure therapy system (10) includes a dialyzer (102); a blood circuit (100) in fluid communication with the dialyzer (102); a dialysis fluid circuit (30) in fluid communication with the dialyzer (102); and an electrically floating fluid pathway (140) comprising at least a portion of the blood circuit (100) and at least a portion of the dialysis fluid circuit (30), wherein the only electrical path to ground is via used dialysis fluid traveling through machine (12) to earth ground (28), and wherein at least one electrical component (46, 90, 82, 66, 102, 116) in the at least a portion of the dialysis fluid circuit (30) of the electrically floating fluid pathway (140) is electrically bypassed.

Abstract: A renal failure therapy system (10a, 10b) includes a dialysis fluid circuit (30) including a dialysis fluid pump (54, 58); a source (86, 90) of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source (22) of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer (20) in operable communication with the dialysis fluid pump (54,58), the logic implementer (20) causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source (86, 90) to be added to purified water from the purified water source (22) to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump (54,58) to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit (30) without a subsequent rinse.

Abstract: Dialysis machines comprising a feed arrangement (170) to supply a dialysis fluid to a dialyzer (150) during dialysis treatment and a return arrangement (171) to remove the dialysis fluid from the dialyzer during dialysis treatment and forward it to an exit (129); a feed recirculation circuit (172) to allow a fluid of the feed arrangement to be re-circulated in a fluid loop path comprising, at least a portion of, the feed arrangement and the feed recirculation circuit and a return recirculation circuit (173) to allow a fluid of the return arrangement to re-circulate in an auxiliary fluid loop path comprising, at least a portion of, the return arrangement and the return recirculation circuit. A controller (160) configured to perform disinfection by re-circulating a disinfectant and/or a heated fluid through said fluid loop path and/or through said auxiliary fluid loop path.

Abstract: An extracorporeal therapy system includes: (i) a dialysis fluid circuit including dialysis fluid preparation structure configured to prepare a dialysis fluid for an extracorporeal therapy treatment; (ii) a blood circuit including a blood filter for use during the extracorporeal therapy treatment; (iii) a blood pump operable to pump blood through the blood circuit and blood filter; and (iv) a control unit operable with the dialysis fluid preparation structure and the blood pump, the control unit programmed to prepare a gas generation fluid different than the dialysis fluid for the extracorporeal therapy treatment, wherein the gas generation fluid generates carbon dioxide (“CO2”) gas, and wherein the CO2 gas is used to prime the blood circuit including the blood filter.

Abstract: A renal failure therapy system includes a dialyzer; a blood circuit in fluid communication with the dialyzer; a dialysis fluid circuit in fluid communication with the dialyzer; a housing supporting the dialyzer, the blood circuit and the dialysis fluid circuit; and at least one electrical socket held by the housing, the electrical socket providing a voltage output dedicated to a particular voltage type of external electrical device for powering or charging the external electrical device, the at least one electrical socket including electrical insulation for protecting a patient while powering the external electrical device.