Patents by Inventor Su Chul Jang
Su Chul Jang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240167036Abstract: The present disclosure relates to extracellular vesicles, e.g, exosomes, comprising an NLRP3 antagonist. In some aspects, the NLRP3 antagonist comprises an antisense oligonucleotide (ASO). Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders, such as, for example, a peripheral neuropathy.Type: ApplicationFiled: February 17, 2022Publication date: May 23, 2024Inventors: Ajay VERMA, Kyriakos ECONOMIDES, Katherine KIRWIN, Joanne LIM, Su Chul JANG
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Publication number: 20240092141Abstract: An air conditioning device for a vehicle includes: a housing having an inside divided into an inflow space, a heat exchange space, and an outflow space, which are straightly arranged, and having a plurality of discharge ports, which communicates with an interior, at the inflow space; a blowing unit disposed at the inflow space of the housing and configured to blow air; a heat exchange unit disposed at the heat exchange space of the housing and configured to adjust a temperature of conditioned air by exchanging heat with air; and an opening-closing door disposed at the outflow space of the housing and configured to open and close the plurality of discharge ports such that conditioned air at an adjusted temperature selectively flows to the plurality of discharge ports. The air conditioning device adjusts the temperature of conditioned air for respective modes and reduces a flow resistance of air.Type: ApplicationFiled: March 8, 2023Publication date: March 21, 2024Applicants: HYUNDAI MOTOR COMPANY, KIA CORPORATION, DOOWON CLIMATE CONTROL CO., LTD.Inventors: Kwang Ok Han, Young Tae Song, Yong Chul Kim, Gee Young Shin, Su Yeon Kang, Jae Sik Choi, Dae Hee Lee, Byeong Moo Jang, Ung Hwi Kim, Jae Won Cha, Won Jun Joung, Byung Guk An
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Publication number: 20230364127Abstract: The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), wherein the ASO comprises a contiguous nucleotide sequence of 10 to 30 nucleotides in length that is complementary to a nucleic acid sequence within a STAT6 transcript. Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.Type: ApplicationFiled: October 6, 2021Publication date: November 16, 2023Applicant: CODIAK BIOSCIENCES, INC.Inventors: Tim SOOS, Sushrut KAMERKAR, Su Chul JANG, Kyriakos ECONOMIDES, Dalia BURZYN
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Publication number: 20230103726Abstract: Provided herein are methods of preparing EVs, e.g., exosomes, associated with or encapsulated various cyclic dinucleotides, including STING agonists. Also provided herein are methods of loading EVs, e.g., exosomes, with various cyclic dinucleotides, including STING agonists.Type: ApplicationFiled: September 25, 2020Publication date: April 6, 2023Applicant: Codiak BioSciences, Inc.Inventors: Raymond BOURDEAU, Su Chul JANG, Rane HARRISON, Conlin O'NEIL, Aaron NOYES
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Patent number: 11561223Abstract: Disclosed is a method of isolating extracellular vesicles and identifying membrane proteins therefrom. The method includes providing human plasma and/or serum; separating lipoproteins and extracellular vesicles from the human plasma and/or serum by a density gradient preparation, collecting the extracellular vesicles from the separated lipoproteins and extracellular vesicles; isolating and purifying the collected extracellular vesicles by using size exclusion chromatography; treating the isolated and purified extracellular vesicles with an aqueous solution to obtain membranes of the extracellular vesicles, wherein the aqueous solution has a pH in a range of 9 to 14; adding salt in a concentration range between 0.5-2.0M to the aqueous solution; isolating the membranes from the treated extracellular vesicles and identifying proteins on the isolated membranes by employing mass spectrometry.Type: GrantFiled: September 17, 2018Date of Patent: January 24, 2023Assignee: Exocure Biosciences Inc.Inventors: Jan Lotvall, Su Chul Jang, Aleksander Cvjetkovic, Cecilia Lasser
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Publication number: 20220334120Abstract: The present disclosure relates to a method of isolating extracellular vesicles directly from human tissues. The invention further relates to a method of identifying disease and tissue specific membrane proteins on extracellular vesicles by membrane isolation and proteomic analysis. The invention further relates to methods of diagnosing diseases by capturing extracellular vesicles by the use of disease specific membrane proteins from body fluids, and detecting or analyzing molecular signatures (proteome, DNA, and RNA) on captured extracellular vesicles. Moreover, the present invention relates to kits, apparatus and software required for implementing aforementioned methods.Type: ApplicationFiled: April 28, 2022Publication date: October 20, 2022Inventors: Jan Lötvall, Su Chul Jang, Rossella Crescitelli
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Patent number: 11333665Abstract: The present disclosure relates to a method of isolating extracellular vesicles directly from human tissues. The invention further relates to a method of identifying disease and tissue specific membrane proteins on extracellular vesicles by membrane isolation and proteomic analysis. The invention further relates to methods of diagnosing diseases by capturing extracellular vesicles by the use of disease specific membrane proteins from body fluids, and detecting or analyzing molecular signatures (proteome, DNA, and RNA) on captured extracellular vesicles. Moreover, the present invention relates to kits, apparatus and software required for implementing aforementioned methods.Type: GrantFiled: March 22, 2018Date of Patent: May 17, 2022Assignee: Exocure Biosciences, Inc.Inventors: Jan Lotvall, Su Chul Jang, Rossella Crescitelli
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Publication number: 20210322327Abstract: Provided herein are compositions comprising EV, e.g., exosome, encapsulated STING agonists and methods of producing the compositions described. Also provided herein are methods of modulating an immune response via administration of a therapeutic amount of EV, e.g., exosomes encapsulating STING agonists. The immune response may be an IEN? response or activation of myeloid dendritic cells (mDCs). Also provided herein are methods of modulating an immune response that does not induce systemic inflammation via administration of exosomes encapsulating STING agonists.Type: ApplicationFiled: March 22, 2019Publication date: October 21, 2021Inventors: Su Chul JANG, Chang Ling SIA, Nuruddeen D. LEWIS, Rane A. HARRISON, Raymond J. MONIZ, Sriram SATHYANARAYANAN, Douglas E. WILLIAMS, Kyriakos ECONOMIDES
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Publication number: 20200249234Abstract: Disclosed is a method of isolating extracellular vesicles and identifying membrane proteins therefrom. The method includes providing human plasma and/or serum; separating lipoproteins and extracellular vesicles from the human plasma and/or serum by a density gradient preparation, collecting the extracellular vesicles from the separated lipoproteins and extracellular vesicles; isolating and purifying the collected extracellular vesicles by using size exclusion chromatography; treating the isolated and purified extracellular vesicles with an aqueous solution to obtain membranes of the extracellular vesicles, wherein the aqueous solution has a pH in a range of 9 to 14; adding salt in a concentration range between 0.5-2.0M to the aqueous solution; isolating the membranes from the treated extracellular vesicles and identifying proteins on the isolated membranes by employing mass spectrometry.Type: ApplicationFiled: September 17, 2018Publication date: August 6, 2020Inventors: Jan LOTVALL, Su Chul JANG, Aleksander CVJETKOVIC, Cecilia LASSER
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Patent number: 10675244Abstract: The present invention relates to a microvesicle that is derived from nucleated mammalian cells, which are smaller than the nucleated cells. The microvesicles of the present invention can be used in the delivery of a therapeutic or diagnostic substance to specific tissues or cells, and more particularly, relates to microvesicles derived from monocytes, macrophages, dendritic cells, stem cells or the like, which can be used to deliver specific therapeutic or diagnostic substances for treating and/or diagnosing tissue associated with cancer, diseased blood vessels, inflammation, or the like.Type: GrantFiled: April 23, 2018Date of Patent: June 9, 2020Assignee: MDIMUNE INC.Inventors: Yong Song Gho, Yoon Keun Kim, Su Chul Jang, Oh Youn Kim, Dong-Sic Choi, Yae Jin Yoon
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Publication number: 20200155703Abstract: The present invention relates to a method for producing membrane vesicles from extracellular vesicles or organelles and therapeutic membrane vesicles produced by such method. The invention further relates to therapeutic membrane vesicles, a method of treating a metabolic disorder by using such vesicles and such vesicles for use in therapy, such as in treatment of a metabolic disorder. The invention further relates to a method of producing a membrane vesicle from an organelle. In addition, the present invention relates to a method of separating a sub-population of extracellular vesicles from an extracellular vesicle bulk.Type: ApplicationFiled: March 15, 2017Publication date: May 21, 2020Inventors: Jan Lõtvall, Su Chul Jang
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Publication number: 20200088734Abstract: The present disclosure relates to a method of isolating extracellular vesicles directly from human tissues. The invention further relates to a method of identifying disease and tissue specific membrane proteins on extracellular vesicles by membrane isolation and proteomic analysis. The invention further relates to methods of diagnosing diseases by capturing extracellular vesicles by the use of disease specific membrane proteins from body fluids, and detecting or analyzing molecular signatures (proteome, DNA, and RNA) on captured extracellular vesicles. Moreover, the present invention relates to kits, apparatus and software required for implementing aforementioned methods.Type: ApplicationFiled: March 22, 2018Publication date: March 19, 2020Inventors: Jan Lotvall, Su Chul Jang, Rossella Crescitelli
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Patent number: 10130725Abstract: A method for labeling exosomes with a radioactive substance using an amine group on surfaces of the exosomes includes providing a cell-derived exosome, treating a surface of the exosome with N-hydroxysuccinimide-azadibenzocyclooctyne (NHS-ADIBO), and mixing the treated exosome with N3-introduced chelator-radioactive substance to conduct a reaction between the chelator and an amine group present on the surface of the exosome, wherein the radioactive substance is introduced inside the exosome by the above reaction. The exosomes can be stably labeled at high labeling efficiency, and the exosomes can be favorably used as an agent for nuclear medicine imaging and therapeutic imaging for confirming the biological distribution of exosomes and whether the exosomes move to target organs and target diseases in animals including a human being.Type: GrantFiled: May 13, 2015Date of Patent: November 20, 2018Assignees: SNU R&DB FOUNDATION, POSTECH ACADEMY—INDUSTRY FOUNDATIONInventors: Dong Soo Lee, Do Won Hwang, Hongyoon Choi, Yun-Sang Lee, Jae Min Jeong, Yong Song Gho, Su Chul Jang
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Publication number: 20180296483Abstract: The present invention relates to a microvesicle that is derived from nucleated mammalian cells, which are smaller than the nucleated cells. The microvesicles of the present invention can be used in the delivery of a therapeutic or diagnostic substance to specific tissues or cells, and more particularly, relates to microvesicles derived from monocytes, macrophages, dendritic cells, stem cells or the like, which can be used to deliver specific therapeutic or diagnostic substances for treating and/or diagnosing tissue associated with cancer, diseased blood vessels, inflammation, or the like.Type: ApplicationFiled: April 23, 2018Publication date: October 18, 2018Applicant: MDIMUNE INC.Inventors: Yong Song Gho, Yoon Keun Kim, Su Chul Jang, Oh Youn KIM, Dong-Sic CHOI, Yae Jin YOON
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Publication number: 20170143856Abstract: A method for labeling exosomes with a radioactive substance using an amine group on surfaces of the exosomes includes providing a cell-derived exosome, treating a surface of the exosome with N-hydroxysuccinimide-azadibenzocyclooctyne (NHS-ADIBO), and mixing the treated exosome with N3-introduced chelator-radioactive substance to conduct a reaction between the chelator and an amine group present on the surface of the exosome, wherein the radioactive substance is introduced inside the exosome by the above reaction. The exosomes can be stably labeled at high labeling efficiency, and the exosomes can be favorably used as an agent for nuclear medicine imaging and therapeutic imaging for confirming the biological distribution of exosomes and whether the exosomes move to target organs and target diseases in animals including a human being.Type: ApplicationFiled: May 13, 2015Publication date: May 25, 2017Applicants: SNU R&DB FOUNDATION, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Dong Soo LEE, Do Won HWANG, Hongyoon CHOI, Yun-Sang LEE, Jae Min JEONG, Yong Song GHO, Su Chul JANG
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Patent number: 9220763Abstract: The present invention relates to a cancer vaccine, and specifically, to a pharmaceutical composition for treating cancer containing a nano-vehicle derived from tumor tissue, and a method for treating cancer using the nano-vehicle derived from tumor tissue, and the like. According to the present invention, a nano-vehicle antigen derived from tumor tissue indicates a high yield while having properties similar to those of an exocellular vehicle, and can be variously modified, and is thus expected to be very useful for developing the cancer vaccine.Type: GrantFiled: May 25, 2012Date of Patent: December 29, 2015Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Yong Song Gho, Yoon Keun Kim, Eun Yeong Lee, Su Chul Jang
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Patent number: 9149542Abstract: The present application relates to microvesicles derived from a protoplast which is a bacterial, arhaea, fungal or plant cell or the like from which a cell wall is removed. The microvesicles derived from a protoplast enables free loading of a material necessary for diagnosis, treatment, vaccine, target induction, cell membrane fusion with a target cell, reduction of in vivo and in vitro side effects, stability improvement, and the like, and allows the therapeutic material, the diagnostic material and/or the vaccine material to be delivered specifically to a specific tissue or cell.Type: GrantFiled: June 30, 2011Date of Patent: October 6, 2015Assignee: AEON MEDIX INC.Inventors: Yong Song Gho, Su Chul Jang, Yoon Keun Kim, Oh Youn Kim
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Patent number: 9084830Abstract: The present application relates to microvesicles derived from a protoplast which is a bacterial, arhaea, fungal or plant cell or the like from which a cell wall is removed. The microvesicles derived from a protoplast enables free loading of a material necessary for diagnosis, treatment, vaccine, target induction, cell membrane fusion with a target cell, reduction of in vivo and in vitro side effects, stability improvement, and the like, and allows the therapeutic material, the diagnostic material and/or the vaccine material to be delivered specifically to a specific tissue or cell.Type: GrantFiled: March 2, 2015Date of Patent: July 21, 2015Assignee: AEON MEDIX INC.Inventors: Yong Song Gho, Su Chul Jang, Yoon Keun Kim, Oh Youn Kim
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Patent number: 9066971Abstract: Disclosed is a method for the treatment and/or diagnosis of cancer, using bacterial cell-derived microvesicles, which is highly effective in cancer therapy with a significant reduction in side effects. Also, a method is provided for delivering of a drug therapeutic or diagnostic for a disease, using bacterial cell-derived microvesicles loaded with the drug, thereby treating and diagnosing the disease effectively and specifically.Type: GrantFiled: June 30, 2011Date of Patent: June 30, 2015Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Yong Song Gho, Oh Youn Kim, Su Chul Jang, Chang Min Yoon, Yoon Keun Kim
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Publication number: 20150174271Abstract: The present application relates to microvesicles derived from a protoplast which is a bacterial, arhaea, fungal or plant cell or the like from which a cell wall is removed. The microvesicles derived from a protoplast enables free loading of a material necessary for diagnosis, treatment, vaccine, target induction, cell membrane fusion with a target cell, reduction of in vivo and in vitro side effects, stability improvement, and the like, and allows the therapeutic material, the diagnostic material and/or the vaccine material to be delivered specifically to a specific tissue or cell.Type: ApplicationFiled: March 2, 2015Publication date: June 25, 2015Inventors: Yong Song GHO, Su Chul JANG, Yoon Keun KIM, Oh Youn KIM