Patents by Inventor Su Jane Rutledge

Su Jane Rutledge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of identifying modulators of protein tyrosine phosphatase activity
    Patent number: 6214564
    Abstract: A human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This PTP, denoted PTP-OB, has a receptor-like three dimensional structure and is present in osteoblasts. PTP-OB is involved in osteoblast differentiation, and modulators of PTP-OB activity in turn modulate osteoblast differentiation, osteoclast differentiation and osteoclast activity.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: April 10, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Gideon A. Rodan, Su Jane Rutledge, Azriel Schmidt
  • Human steroid receptor
    Patent number: 5939322
    Abstract: Through the use of the novel receptor NER in a screening procedure, TOFA (5-tetradecyloxy)-2-furan-carboxylic acid) has been found to modulate other receptors and to be a potent potentiator of other drugs. TOFA activates the NER receptor. The NER receptor is a novel member of the steroid hormone receptor family and has been prepared by cDNA cloning from a human osteosarcoma SAOS-2/B10 cell library. Also disclosed is the complete sequence of human NER cDNA; a COS stable expression system; the expressed NER protein; and an assay using the COS expression system. In addition, the invention relates to a method for identifying functional ligands of the NER receptor.
    Type: Grant
    Filed: May 14, 1996
    Date of Patent: August 17, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Gideon A. Rodan, Su Jane Rutledge, Azriel Schmidt, Robert L. Vogel
  • Human protein tyrosine phosphatase OB protein
    Patent number: 5866397
    Abstract: A novel human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This novel PTP, denoted PTP-OB, has a receptor-like three dimensional structure and is present in osteoblasts. PTP-OB is involved in osteoblast differentiation, and modulators of PTP-OB activity in turn modulate osteoblast differentiation, osteoclast differentiation and osteoclast activity.
    Type: Grant
    Filed: February 14, 1997
    Date of Patent: February 2, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Gideon A. Rodan, Su Jane Rutledge, Azriel Schmidt
  • Wnt-x growth factor polypeptide, DNA encoding same, and Wnt-x antibody
    Patent number: 5780291
    Abstract: A novel member of the Wnt-family of growth factors, termed Wnt-x, has been identified and DNA encoding the growth factor has been isolated, purified, sequenced and expressed in host cells. This DNA encoding the novel Wnt-x protein and host cells expressing the Wnt-x protein are used to identify modulators of the Wnt-x growth factor.
    Type: Grant
    Filed: May 22, 1996
    Date of Patent: July 14, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Gideon A. Rodan, Su Jane Rutledge, Azriel Schmidt
  • Method for finding transcription activators of the NER steroid hormone receptor
    Patent number: 5679518
    Abstract: The NER receptor is a novel member of the steroid hormone receptor superfamily and has been prepared by cDNA cloning from a human osteosarcoma SAOS-2/B10 cell library. The complete sequence of human NER complementary DNA (Seq. ID No. 1), expression systems including a COS stable expression system, the expressed protein (SEQ. ID No. 2) and an assay using the COS expression system are disclosed. The assay may be used to identify agents which activate transcription mediated by the NER receptor, and which are useful for potentiating the activity of a modulator of a G-protein coupled receptor wherein the G-protein coupled receptor is a member of the steroid hormone receptor superfamily.
    Type: Grant
    Filed: October 27, 1994
    Date of Patent: October 21, 1997
    Assignees: Merck & Co., Inc., Medical College of Pennsylvania, Hahnemann Univ.
    Inventors: Eitan Friedman, M. Katharine Holloway, Gideon A. Rodan, Su Jane Rutledge, Azriel Schmidt, Robert L. Vogel
  • CDNA encoding a novel human protein tyrosine phosphatase
    Patent number: 5658756
    Abstract: A novel human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This novel PTP, denoted PTP-OB, has a receptor-like three dimensional structure and is present in osteoblasts. PTP-OB is involved in osteoblast differentiation, and modulators of PTP-OB activity in turn modulate osteoblast differentiation, osteoclast differentiation and osteoclast activity.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: August 19, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Gideon A. Rodan, Su Jane Rutledge, Azriel Schmidt