Abstract: The present invention generally relates to an image guided variable spot stimulation-based electrophysiology assessment device for different biomedical applications. Specifically, the invention relates to application of the device to perform image-guided functional assessment upon variable spot optical stimulation of light-activatable biological specimens to determine changes in the functional health during disease progression and therapy. More specifically, the invention relates to the application of the device in the diagnosis of visual and neurological disorders.

Abstract: The present invention generally relates to an image-guided laser irradiation device for targeted ablation, stimulation, molecular delivery and therapy. Specifically, the invention relates to application of the device in therapies needing precise and targeted removal of a sample, or delivery of impermeable molecules for therapeutic outcome. More specifically, the invention relates to the application of the device in the therapy of visual disorders.

Abstract: The present invention generally relates to the novel method, compositions and applications of mechanosensitive channels in therapeutics for visual, neurological and other disorders. Specifically, the invention relates to exploitation of mechanosensitive channels' intrinsic property as a transgenic pressure modulator and alternative outflow actuator in the treatment of different diseases such as glaucoma, blood pressure and other diseases involving of cells prone to mechanical or osmotic stress. Furthermore, the invention relates to exploitation of mechanosensitive channels for stimulation of cells enabling therapies for different diseases including pain, as well as molecular delivery to cells triggered by internal and/or external mechanical stimuli.

Abstract: This invention, in one aspect, relates generally to compositions and methods for modulating cellular activities by synthetic opsins. Further, the invention provides method for the use of synthetic opsins for vision restoration and other applications, wherein the amino acid sequence of the synthetic opsin is modified to provide enhanced light sensitivity, kinetics and ion-selectivity.

Abstract: Principles of the present disclosure are directed to novel methods and devices for focal or global optical stimulation of retina and detecting activity of the retina by collecting and processing the back-scattered optical signal from the retina (Optical RetinoGram). Specifically, the invention provides device and method for quantitatively determining the layer specific activity of retina from the acquired intrinsic back reflected signal by monitoring phase/intensity fluctuations and thereafter employing multifractality algorithm on optical signal for obtaining various multifractal parameters such as width of singularity spectrum, Hurst exponent, fractal dimension, locally connected fractal mapping as well as artificial intelligence based classification for the use of diagnosis of retinal degenerative/ocular disease(s) and asses the progression of diseases or recovery of function due to one or more treatment by therapeutic drugs, devices, protocols.

Abstract: The present invention generally relates to an image-guided laser irradiation device for targeted ablation, stimulation, molecular delivery and therapy. Specifically, the invention relates to application of the device in therapies needing precise and targeted removal of a sample, or delivery of impermeable molecules for therapeutic outcome. More specifically, the invention relates to the application of the device in the therapy of visual disorders.

Abstract: Principles of the present disclosure are directed to novel methods and devices for focal or global optical stimulation of retina and detecting activity of the retina by collecting and processing the back-scattered optical signal from the retina (Optical RetinoGram). Specifically, the invention provides device and method for quantitatively determining the layer specific activity of retina from the acquired intrinsic back reflected signal by monitoring phase/intensity fluctuations and thereafter employing multifractality algorithm on optical signal for obtaining various multifractal parameters such as width of singularity spectrum, Hurst exponent, fractal dimension, locally connected fractal mapping as well as artificial intelligence based classification for the use of diagnosis of retinal degenerative/ocular disease(s) and asses the progression of diseases or recovery of function due to one or more treatment by therapeutic drugs, devices, protocols.