Patents by Inventor Sudhakar Godeshala

Sudhakar Godeshala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemotherapeutic drug-conjugated resins and their preferential binding of methylated DNA
    Patent number: 10907145
    Abstract: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: February 2, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Kaushal Rege, Kevin Lin, Sudhakar Godeshala, Taraka Sai Pavan Grandhi
  • CHEMOTHERAPEUTIC DRUG-CONJUGATED RESINS AND THEIR PREFERENTIAL BINDING OF METHYLATED DNA
    Publication number: 20180258416
    Abstract: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
    Type: Application
    Filed: March 8, 2018
    Publication date: September 13, 2018
    Inventors: Kaushal Rege, Kevin Lin, Sudhakar Godeshala Godeshala, Taraka Sai Pavan Grandhi