Abstract: The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the frequency of cancer stem cells, as well as novel methods of screening for such Wnt antagonists. In particular, the invention discloses soluble FZD, SFRP and Ror receptors and their use.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.

Abstract: The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

Abstract: The present invention is based, at least in part, upon discovery of a process for identifying phase changing peptides. Such phase changing peptides are capable of enhancing in vitro and in vivo delivery of oligonucleotides (e.g., dsRNAs) in lipidic, vesicular, micellar and/or naked oligonucleotide formulations.

Abstract: Disclosed is a rotating electric machine for generating a constant frequency AC power supply from a variable speed primemover including: a stator wound with two sets of isolated polyphase windings having the same number of poles, with the polyphase windings located at about 90 degree displacement in space between them, and a rotor wound with two sets of isolated polyphase windings having the same number of poles and placed at about 90 degree displacement in space between them. The rotor has two winding terminals interconnected either internally or externally to the machine with mutually reverse phase sequence. When one set of stator winding is energized by an AC power supply of a given frequency and voltage, and the rotor shaft is rotated by an external means in the same direction as that of the rotating field of the stator.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. Screening methods are also provided.

Abstract: A method for performing access management to facilitate a user to access applications in a single sign-on enabled enterprise solution is provided. A challenge token and a response token are transmitted between a server and a client. The challenge token and response token comprises one-way hashed data. The response token is verified at the server and the client to authenticate the user. Further, a request for service token is transmitted between the server and the client. The request for service token is encrypted at the client and decrypted at the server using a unique session key negotiated between the server and client. A service token is generated and transmitted between the server and the client. The service token is encrypted and decrypted at the server using a secret key to verify the service token. Based on the verification, the requested applications are rendered on client based user interface.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.

Abstract: A catalytic electrode may include a complex oxide deposited on a substrate. The complex oxide maybe an oxide of an alloy of ruthenium and another less expensive metal, including without limitation cobalt and manganese. The percentage of ruthenium in the complex oxide can be reduced to about 20 percent or less, while still allowing the electrode to maintain adequate electrocatalytic activity during redox reactions at the electrode. Electrodes can be synthesized using RuCo oxides with ruthenium content reduced to about 5%, or using RuMn oxides having ruthenium content reduced to about 10%, while maintaining good catalytic activity. These electrodes may be used in electrochemical cells including without limitation fuel cells, flow batteries and regenerative fuel cells such as halogen fuel cells or hydrogen-halogen fuel cells. These electrodes may also be used in electrolytic cells.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.

Abstract: A formulation is provided which comprises at least one phenolic compound in an amount of about 0.5 to about 1.2% of the mass of the formulation; at least one fragrance in an amount of about 0.3 to about 1.0% of the mass of the formulation; and at least one alcohol in an amount of about 90 to about 99% of the mass of the formulation. Said formulation is surfactant free and being capable of rendering anti-microbial finish to fabrics. And also, a process for preparing a fabric with anti-microbial finish is provided.

Abstract: A method for identification of an instable network operator service (NOS) plan having one or more mobile users. Instable NOS plans are determined by first determining a heterogeneity constant for each of a plurality of NOS plans. Based at least in part on the constant, the NOS plans are classified among different categories, wherein at least one category identifies an instable NOS plan. For each of the mobile users subscribed to at least one of the instable NOS plan category, determining a best NOS plan from amongst the plurality of NOS plans and a sample network operator service plan based at least in part on a spending behavior of the respective ones of the mobile users. Identifying, the instable NOS plan from amongst the plurality of NOS plans in which maximum number of mobile users correspond to the sample NOS plan as the correspondingly determined best NOS plan.

Abstract: Disclosed is a rotating electric machine for generating a constant frequency AC power supply from a variable speed primemover including: a stator wound with two sets of isolated polyphase windings having the same number of poles, with the polyphase windings located at about 90 degree displacement in space between them, and a rotor wound with two sets of isolated polyphase windings having the same number of poles and placed at about 90 degree displacement in space between them. The rotor has two winding terminals interconnected either internally or externally to the machine with mutually reverse phase sequence. When one set of stator winding is energized by an AC power supply of a given frequency and voltage, and the rotor shaft is rotated by an external means in the same direction as that of the rotating field of the stator.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.

Abstract: The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the frequency of cancer stem cells, as well as novel methods of screening for such Wnt antagonists. In particular, the invention discloses soluble FZD, SFRP and Ror receptors and their use.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.

Abstract: A substantially porous, micro-particle comprising therapeutically effective amounts of tretinoin and ethyl cellulose

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.