Patents by Inventor Sumio Sugano
Sumio Sugano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10145849Abstract: [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth. [MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of SEQ ID NO: 1, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.Type: GrantFiled: September 10, 2015Date of Patent: December 4, 2018Assignee: FUJIFILM CorporationInventors: Sumio Sugano, Yukari Kanzaki, Tsuneo Saga, Atsushi Tsuji
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Patent number: 9377461Abstract: [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth. [MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of any of SEQ ID NOs: 1 to 3, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.Type: GrantFiled: March 8, 2011Date of Patent: June 28, 2016Assignee: FUJIFILM CorporationInventors: Sumio Sugano, Yukari Kanzaki, Tsuneo Saga, Atsushi Tsuji
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Publication number: 20160068593Abstract: [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth. [MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of SEQ ID NO: 1, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.Type: ApplicationFiled: September 10, 2015Publication date: March 10, 2016Applicant: FUJIFILM CORPORATIONInventors: Sumio SUGANO, Yukari KANZAKI, Tsuneo SAGA, Atsushi TSUJI
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Patent number: 9164096Abstract: [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth. [MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of SEQ ID NO: 1, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.Type: GrantFiled: March 8, 2011Date of Patent: October 20, 2015Assignee: FUJIFILM CorporationInventors: Sumio Sugano, Yukari Kanzaki, Tsuneo Saga, Atsushi Tsuji
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Publication number: 20130040311Abstract: [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth. [MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of any of SEQ ID NOs: 1 to 3, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.Type: ApplicationFiled: March 8, 2011Publication date: February 14, 2013Applicant: FUJIFILM CORPORATIONInventors: Sumio Sugano, Yukari Kanzaki, Tsuneo Saga, Atsushi Tsuji
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Publication number: 20120328528Abstract: [PROBLEM] To provide a monoclonal antibody against a biomarker which shows high specificity and can be effectively used in detection and diagnosis of various lesions relevant to various kinds of carcinomas and foci of necrosis, and so forth. [MEANS] A monoclonal antibody against a necrosis marker consisting the following amino acid sequence: (1) the amino acid sequence of SEQ ID NO: 1, or (2) an amino acid sequence having substitution, deletion and/or insertion of one or several amino acid residues in the amino acid sequence of (1) or sharing a homology of 90% or more with the amino acid sequence of (1), and showing the same function, activity or property as that of the amino acid sequence of (1) as a protein.Type: ApplicationFiled: March 8, 2011Publication date: December 27, 2012Applicant: FUJIFILM CORPORATIONInventors: Sumio Sugano, Yukari Kanzaki, Tsuneo Saga, Atsushi Tsuji
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Patent number: 7858091Abstract: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.Type: GrantFiled: January 11, 2008Date of Patent: December 28, 2010Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Kazuya Yamano, Susumu Sekine, Mitsuo Satoh, Toshio Ota, Akiko Furuya, Kenji Shibata, Yuki Kobayashi, Miho Takebayashi, Yusuke Nakamura, Sumio Sugano
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Publication number: 20090117538Abstract: The present invention provides methods for providing as tags the nucleotide sequences at the 5? end of mRNA. The method of the present invention comprises the step of synthesizing cDNA using, as a template, mRNA whose CAP structure is linked with a IIs linker having a type IIs endonuclease recognition sequence. Tags including the nucleotide sequence from the 5? end of mRNA are generated by reacting the type IIs endonuclease to cDNA. Tags can be generated from all mRNA, independently of their nucleotide sequences. Methods for identifying transcriptional start sites and primers for full-length cDNA synthesis are provided based on the nucleotide sequence information of tags of the present invention.Type: ApplicationFiled: June 4, 2004Publication date: May 7, 2009Inventors: Shin-ichi Hashimoto, Kouji Matsushima, Sumio Sugano
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Publication number: 20080241960Abstract: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.Type: ApplicationFiled: January 11, 2008Publication date: October 2, 2008Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Kazuya Yamano, Susumu Sekine, Mitsuo Satoh, Toshio Ota, Akiko Furuya, Kenji Shibata, Yuki Kobayashi, Miho Takebayashi, Yusuke Nakamura, Sumio Sugano
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Publication number: 20080044425Abstract: The present invention relates to a novel phospholipase A2 polypeptide, DNA encoding the polypeptide, a vector comprising the DNA, a transformant transformed with the vector, and a process for producing the phospholipase A2 polypeptide. The present invention also relates to a method of utilizing the polypeptide, e.g., a method of screening for a compound having agonist or antagonist activity by using the polypeptide or an antibody to the polypeptide, and a pharmaceutical comprising the polypeptide or an antibody to the polypeptide. The present invention further relates to a polypeptide inhibiting the phospholipase A2 activity of a phospholipase A2 polypeptide (hereinafter referred to as inhibitor polypeptide), DNA encoding the inhibitor polypeptide, a vector comprising the DNA encoding the inhibitor polypeptide, a transformant transformed with the vector, a pharmaceutical comprising the inhibitor polypeptide, and a process for producing the inhibitor polypeptide.Type: ApplicationFiled: July 27, 2007Publication date: February 21, 2008Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Hiromasa Miyaji, Motoko Haruoka, Hiroyuki Nagata, Toshio Ota, Ayako Kawabata, Sumio Sugano, Yusuke Nakamura
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Patent number: 7332301Abstract: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.Type: GrantFiled: March 30, 2006Date of Patent: February 19, 2008Assignee: Kyowa Haakko Kogyo Co. Ltd.Inventors: Kazuya Yamano, Susumu Sekine, Mitsuo Satoh, Toshio Ota, Akiko Furuya, Kenji Shibata, Yuki Kobayashi, Miho Takebayashi, Yusuke Nakamura, Sumio Sugano
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Patent number: 7258855Abstract: The present invention relates to a novel phospholipase A2 polypeptide, DNA encoding the polypeptide, a vector comprising the DNA, a transformant transformed with the vector, and a process for producing the phospholipase A2 polypeptide. The present invention also relates to a method of utilizing the polypeptide, e.g., a method of screening for a compound having agonist or antagonist activity by using the polypeptide or an antibody to the polypeptide, and a pharmaceutical comprising the polypeptide or an antibody to the polypeptide. The present invention further relates to a polypeptide inhibiting the phospholipase A2 activity of a phospholipase A2 polypeptide (hereinafter referred to as inhibitor polypeptide), DNA encoding the inhibitor polypeptide, a vector comprising the DNA encoding the inhibitor polypeptide, a transformant transformed with the vector, a pharmaceutical comprising the inhibitor polypeptide, and a process for producing the inhibitor polypeptide.Type: GrantFiled: September 19, 2001Date of Patent: August 21, 2007Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiromasa Miyaji, Motoko Haruoka, Hiroyuki Nagata, Toshio Ota, Ayako Kawabata, Sumio Sugano, Yusuke Nakamura
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Publication number: 20060216739Abstract: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.Type: ApplicationFiled: March 30, 2006Publication date: September 28, 2006Applicant: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kazuya Yamano, Susumu Sekine, Mitsuo Satoh, Toshio Ota, Akiko Furuya, Kenji Shibata, Yuki Kobayashi, Miho Takebayashi, Yusuke Nakamura, Sumio Sugano
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Patent number: 7071160Abstract: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.Type: GrantFiled: June 15, 2001Date of Patent: July 4, 2006Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kazuya Yamano, Susumu Sekine, Mitsuo Satoh, Toshio Ota, Akiko Furuya, Kenji Shibata, Yuki Kobayashi, Miho Takebayashi, Yusuke Nakamura, Sumio Sugano
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Publication number: 20050074762Abstract: A novel adiponectin-like protein having therapeutic and/or preventive effects on arteriosclerosis and a gene encoding this protein are provided. A protein (a) comprising the amino acid sequence represented by SEQ ID No:3 or a protein (b) comprising an amino acid sequence resulting from deletion, substitution or addition of amino acid(s) in the amino acid sequence of SEQ ID NO:3 and having an activity of inhibiting the proliferation of vascular smooth muscle cells or salts of these proteins; and a DNA encoding the above proteins are provided.Type: ApplicationFiled: February 1, 2002Publication date: April 7, 2005Inventors: Yusuke Nakamura, Sumio Sugano, Takashi Yano, Hiroyuki Kawano, Hisayuki Watanabe
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Publication number: 20040234978Abstract: A gene and a protein participating in diseases of central nervous system and a method of efficiently evaluating an activity controller for the protein are provided.Type: ApplicationFiled: April 19, 2004Publication date: November 25, 2004Inventors: Yusuke Nakamura, Sumio Sugano, Fumiaki Yamasaki, Shoji Furusako, Kazufumi Okawa, Tomohiro Takahashi
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Publication number: 20040115682Abstract: A gene and a protein participating in arteriosclerosis caused by foam macrophages and a method of efficiently evaluating an agent controlling an activity of this protein are provided.Type: ApplicationFiled: January 12, 2004Publication date: June 17, 2004Inventors: Yusuke Nakamura, Sumio Sugano, Hiroyuki Kawano
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Publication number: 20040076992Abstract: A gene of a novel cellular adhesion molecule participating in the regulation of immune functions and a protein, and a method of efficiently evaluating an activity regulator for this protein are provided.Type: ApplicationFiled: December 22, 2003Publication date: April 22, 2004Inventors: Yusuke Nakamura, Sumio Sugano, Yutaka Kato, Tomohiro Takahashi, Kamon Shirakawa
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Publication number: 20040072238Abstract: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.Type: ApplicationFiled: April 9, 2003Publication date: April 15, 2004Inventors: Kazuya Yamano, Susumu Sekine, Mitsuo Satoh, Toshio Ota, Akiko Furuya, Kenji Shibata, Yuki Kobayashi, Miho Takebayashi, Yusuke Nakamura, Sumio Sugano
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Publication number: 20040014089Abstract: The present invention relates to a novel phospholipase A2 polypeptide, DNA encoding the polypeptide, a vector comprising the DNA, a transformant transformed with the vector, and a process for producing the phospholipase A2 polypeptide. The present invention also relates to a method of utilizing the polypeptide, e.g., a method of screening for a compound having agonist or antagonist activity by using the polypeptide or an antibody to the polypeptide, and a pharmaceutical comprising the polypeptide or an antibody to the polypeptide. The present invention further relates to a polypeptide inhibiting the phospholipase A2 activity of a phospholipase A2 polypeptide (hereinafter referred to as inhibitor polypeptide), DNA encoding the inhibitor polypeptide, a vector comprising the DNA encoding the inhibitor polypeptide, a transformant transformed with the vector, a pharmaceutical comprising the inhibitor polypeptide, and a process for producing the inhibitor polypeptide.Type: ApplicationFiled: March 19, 2003Publication date: January 22, 2004Inventors: Hiromasa Miyaji, Motoko Haruoka, Hiroyuki Nagata, Toshio Ota, Ayako Kawabata, Sumio Sugano, Yusuke Nakamura