Abstract: A composition for enhancing efficacy of lactic acid bacteria includes at least two branched-chain amino acids selected from the group consisting of leucine, isoleucine and valine. The composition may enhance physiological activity of lactic acid bacteria, for example, the growth promoting efficacy or the intestinal damage inhibitory efficacy of lactic acid bacteria.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: A microneedle cartridge according to the present disclosure includes a disk-shaped cartridge main body including a rotational force receiver configured to receive a rotational force from a microneedle applicator, a plurality of first through-holes radially disposed about the center of the cartridge main body, a plurality of microneedle bases each disposed in one of the first through-holes and having one or more microneedles disposed on a lower surface, a maintaining member configured to maintain the microneedle base inside the through-hole, and a second through-hole through which a pressing portion of the microneedle applicator passes when operating to seal the microneedle applicator, wherein the microneedle base is configured to be movable between a first position at which the microneedle base is not pressed by the pressing portion and a second position at which the microneedle base is maximally pressed by the pressing portion.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: Disclosed is a drug compliance management method including a microneedle applicator configured to infuse a drug by means of a microneedle in the form of a wearable device, a patient terminal configured to process drug compliance information including drug infusion information received from the microneedle applicator and medication information separately input by a patient after administration, a server configured to transmit the drug compliance information received from the patient terminal, and an expert terminal configured to display drug compliance information collected from a plurality of patient terminals.

Abstract: Proposed is a cartridge (1000) for accommodating a microneedle patch (100) comprising: a body portion (1002) which is accommodated in an accommodating part formed in a housing (201) of an applicator (200), and a flat plate portion (1004), mounted on the body portion (1002), comprising a flat plate opening (1006) through which a pressurizing part (404) of a drive mechanism (400) passes and a fixing portion (1005) operatively coupled to the drive mechanism (400), wherein the flat plate portion (1004) is rotated according to a driving of the drive mechanism (400) and is located below the microneedle patch (100) to supports the microneedle patch (100).

Abstract: Proposed is a microneedle patch including a body in which at least one opening is formed, and a microneedle body which is disposed in the opening and has at least one microneedle formed therein, wherein when an external force is applied in a first direction, the microneedle body moves in the first direction so as to administer a drug in the microneedle to a user’s skin.

Abstract: A strap for a microneedle applicator according to the present disclosure, which is coupled to an applicator main body part of the microneedle applicator in the form of a wearable device to allow the microneedle applicator to be worn on the body, includes a strap part having a structure that is inflatable when air is injected thereinto, a main body connecting part installed at both ends of the strap part, a housing installed at one side of an outer surface of the strap part, a pump installed inside the housing and configured to supply air to be injected into the strap part, a valve installed inside the housing, connected to a communication path along which air is injected into the strap part, and configured to operate to inject air into the strap part or discharge air from inside the strap part to the outside, and a controller configured to control the pump and the valve.

Abstract: Disclosed is a drug compliance management method including a microneedle applicator configured to infuse a drug by means of a microneedle in the form of a wearable device, a patient terminal configured to process drug compliance information including drug infusion information received from the microneedle applicator and medication information separately input by a patient after administration, a server configured to transmit the drug compliance information received from the patient terminal, and an expert terminal configured to display drug compliance information collected from a plurality of patient terminals.

Abstract: A microneedle cartridge according to the present disclosure includes a disk-shaped cartridge main body including a rotational force receiver configured to receive a rotational force from a microneedle applicator, a plurality of first through-holes radially disposed about the center of the cartridge main body, a plurality of microneedle bases each disposed in one of the first through-holes and having one or more microneedles disposed on a lower surface, a maintaining member configured to maintain the microneedle base inside the through-hole, and a second through-hole through which a pressing portion of the microneedle applicator passes when operating to seal the microneedle applicator, wherein the microneedle base is configured to be movable between a first position at which the microneedle base is not pressed by the pressing portion and a second position at which the microneedle base is maximally pressed by the pressing portion.

Abstract: Disclosed is a drug compliance management system including a microneedle applicator configured to infuse a drug by means of a microneedle in the form of a wearable device, a patient terminal configured to process drug compliance information including drug infusion information received from the microneedle applicator and medication information separately input by a patient after administration, a server configured to transmit the drug compliance information received from the patient terminal, and an expert terminal configured to display drug compliance information collected from a plurality of patient terminals.

Abstract: A microneedle applicator according to the present disclosure includes a housing which has a cartridge accommodation space formed to detachably mount a cartridge having a microneedle base and which has a first through-hole formed in a bottom surface to allow the microneedle base to pass, a pressing part which is operated to press the microneedle base or seal the first through-hole, a pressing operation part which is configured to operate the pressing part, a cartridge operation part which is configured to rotate the cartridge so that the microneedle base having a microneedle formed at a lower surface thereof is disposed below the pressing part, a controller which is configured to control the pressing operation part and the cartridge operation part and communicate with an external device, and a battery which is configured to supply necessary power for the pressing operation part, the cartridge operation part, and the controller.

Abstract: Proposed is a cartridge (1000) for accommodating a microneedle patch (100) comprising: a body portion (1002) which is accommodated in an accommodating part formed in a housing (201) of an applicator (200), and a flat plate portion (1004), mounted on the body portion (1002), comprising a flat plate opening (1006) through which a pressurizing part (404) of a drive mechanism (400) passes and a fixing portion (1005) operatively coupled to the drive mechanism (400), wherein the flat plate portion (1004) is rotated according to a driving of the drive mechanism (400) and is located below the microneedle patch (100) to supports the microneedle patch (100).

Abstract: This invention relates to an optical anisotropic film wherein liquid crystals of a liquid crystal layer can be more effectively aligned using a photo-alignment layer, and superior stability of liquid crystal alignment and high interaction between the liquid crystal layer and the photo-alignment layer can be exhibited, and to an optical device including the optical anisotropic film. The optical anisotropic film includes a substrate having P (polarity) of 0.01 to 0.35 as defined by a predetermined equation; a photo-alignment layer formed on the substrate and including a photo-alignment polymer in which at least a portion of a photo-reactive group is optically aligned, with P (polarity) of 0.02 to 0.28; and a liquid crystal layer formed on the photo-alignment layer.

Abstract: An optical film having reverse wavelength dispersion and a display device including the same are provided. The optical film according to the present invention has a thin thickness and excellent reverse wavelength dispersion, and thus it can be suitably applied to a ?/2 wave plate, a ?/4 wave plate, a protection film, and an anti-reflection film of a display device using liquid crystals or OLEDs.

Abstract: Disclosed herein are a cyclic olefin compound, a photoreactive polymer, and an alignment layer comprising the photoreactive polymer, where the cyclic olefin compound can be used to provide the photoreactive polymer having not only excellences in liquid crystal alignment and alignment rate but also readiness for change in the alignment direction depending on the polarization direction.

Abstract: This invention relates to an optical anisotropic film wherein liquid crystals of a liquid crystal layer can be more effectively aligned using a photo-alignment layer, and superior stability of liquid crystal alignment and high interaction between the liquid crystal layer and the photo-alignment layer can be exhibited, and to an optical device including the optical anisotropic film. The optical anisotropic film includes a substrate having P (polarity) of 0.01 to 0.35 as defined by a predetermined equation; a photo-alignment layer formed on the substrate and including a photo-alignment polymer in which at least a portion of a photo-reactive group is optically aligned, with P (polarity) of 0.02 to 0.28; and a liquid crystal layer formed on the photo-alignment layer.

Abstract: Disclosed herein is a photo-alignment polymer, which can be preferably applied to an alignment layer or the like of a three-dimensional display device because its alignment direction is easily changed depending on the polarization direction, and an alignment layer and liquid crystal retardation film including the same. The photo-alignment layer includes a cyclic olefin repeating unit substituted with one or more photoreactive groups, and has an absorbance ratio of 0.

Abstract: Disclosed therein are a cyclic olefin compound, a photoreactive polymer, and an alignment layer comprising the photoreactive polymer, where the cyclic olefin compound can be used to provide the photoreactive polymer having not only excellences in liquid crystal alignment and alignment rate but also readiness for change in the alignment direction depending on the polarization direction.

Abstract: Disclosed herein are a cyclic olefin compound, a photoreactive polymer, and an alignment layer comprising the photoreactive polymer, where the cyclic olefin compound can be used to provide the photoreactive polymer having not only excellences in liquid crystal alignment and alignment rate but also readiness for change in the alignment direction depending on the polarization direction.