Patents by Inventor Sunil S. Karhadkar

Sunil S. Karhadkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Elevated Hedgehog Pathway Activity In Digestive System Tumors, And Methods Of Treating Digestive Sytem Tumors Having Elevated Hedgehog Pathway Activity
    Publication number: 20080118493
    Abstract: Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in digestive tract cancers, including esophagus, stomach, biliary tract, and pancreatic cancer, and determined to be associated with growth and proliferation of the cancer cells. Accordingly, methods are provided for treating a digestive tract cancer associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a digestive tract tumor to treatment with an Hh pathway antagonist.
    Type: Application
    Filed: July 15, 2004
    Publication date: May 22, 2008
    Inventors: Philip A. Beachy, David Monty Berman, Sunil S. Karhadkar, Anirban Maitra
  • Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis
    Publication number: 20080095761
    Abstract: Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in prostate tumors, and determined to be associated with growth and proliferation of the cancer cells. Accordingly, methods are provided for treating a prostate cancer associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a prostate tumor to treatment with an Hh pathway antagonist.
    Type: Application
    Filed: October 1, 2004
    Publication date: April 24, 2008
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Philip A. Beachy, David M. Berman, Sunil S. Karhadkar