Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

Abstract: Provided is a thermoplastic resin composition having excellent electrical properties, and the thermoplastic resin composition comprises: (A) 100 parts by weight of polycarbonate; (B) 2 parts by weight to 6 parts by weight of a cyclic phosphazene compound flame retardant; (C) 0.1 parts by weight to 5 parts by weight of an impact-reinforcing agent; and (D) 1 part by weight to 3 parts by weight of a fluorinated polyolefin.

Abstract: Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a —S(?O)(?N—)- functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

Abstract: Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

Abstract: Disclosed are a pharmaceutical composition for treatment of attention deficit hyperactivity disorder and a food composition for alleviation of attention deficit hyperactivity disorder, each of which contains as an active ingredient a mixture extract of Longan Arillus, Salviae Miltiorrhizae Radix, Gastrodiae Rhizoma, and Liriopis seu Ophiopogonis Tuber, wherein the compositions containing as an active ingredient a mixture extract of Longan Arillus, Salviae Miltiorrhizae Radix, Gastrodiae Rhizoma, and Liriopis seu Ophiopogonis Tuber of the present disclosure inhibits the hyperactivity of glutamate receptors, which is known to be a cause of attention deficit hyperactivity disorder, alleviates clinical symptoms (attention decrease and hyperactivity) of child patients, and shows an improvement effect in fMRI examination results, and thus can be advantageously used as a medicine for attention deficit hyperactivity disorder or a food for alleviation of attention deficit hyperactivity disorder.

Abstract: Provided is a thermoplastic resin composition having excellent electric properties and the thermoplastic resin composition comprises: (A) 100 parts by weight of a polycarbonate resin; (B) 2 to 6 parts by weight of a phosphorous-based flame retardant; and (C) 0.2 parts by weight to 2 parts by weight of a mineral filler.

Abstract: The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

Abstract: An electronic apparatus and a method for controlling the electronic apparatus are provided, the method includes displaying an image window on a first part of a writing area of a display; displaying, based on a first user input for writing being detected on a second part of the writing area that is outside the image window, first writing information corresponding to the first user input on the writing area with a first thickness that is predetermined; and displaying, based on a second user input for writing being detected on the image window, second writing information corresponding to the second user input on the image window with a second thickness that is set according to the first thickness and a display magnification of the image window.

Abstract: A vertical type non-volatile memory device includes a substrate having a cell array area of a block unit and an extension area, a vertical contact disposed in the extension area, a plurality of vertical channel structures provided on the substrate in the cell array area, a plurality of dummy channel structures provided on the substrate in the extension area, and a plurality of gate electrode layers and a plurality of interlayer insulation layers stacked alternately on the substrate. In an electrode pad connected to the vertical contact, dummy channel structures are disposed at both sides of the vertical contact and a horizontal cross-sectional surface of each of the plurality of dummy channel structures has a shape which is longer in one direction.

Abstract: A chute type monomer dispenser is provided in the present disclosure. The chute type monomer dispenser includes a chute dispenser installed to be slanted in a direction of a polymerization apparatus, the chute dispenser is configured to inject a monomer to the polymerization apparatus through an injection pipe having an injection portion having an opening at an upper portion of the chute dispenser; and an injector configured to inject an initiator and a foaming agent to the injection portion.

Abstract: An electronic device having an electronic board function and an operation method thereof. The electronic device includes: a display; a touch input interface; a memory storing at least one instruction; and a processor configured to execute the at least one instruction stored in the memory to: display a writing area in a display area of the display; detect a predefined touch input in the writing area; and based on detecting the predefined touch input, reduce the writing area, display the reduced writing area in at least first part of the display area and provide an extended area in at least second part of the display area, the extended area being configured to receive a writing input continuing from the reduced writing area to the extended area.

Abstract: A chute type monomer dispenser is provided in the present disclosure. The chute type monomer dispenser includes a chute dispenser installed to be slanted in a direction of a polymerization apparatus, the chute dispenser is configured to inject monomer to the polymerization apparatus through an injection pipe having an injection portion having an opening at an upper portion of the chute dispenser; and an injector configured to inject an initiator and a foaming agent to the injection portion.

Abstract: An electronic apparatus and a method for controlling the electronic apparatus are provided, the method includes displaying an image window on a first part of a writing area of a display; displaying, based on a first user input for writing being detected on a second part of the writing area that is outside the image window, first writing information corresponding to the first user input on the writing area with a first thickness that is predetermined; and displaying, based on a second user input for writing being detected on the image window, second writing information corresponding to the second user input on the image window with a second thickness that is set according to the first thickness and a display magnification of the image window.

Abstract: The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g.