Patents by Inventor Suong-Hyu Hyon
Suong-Hyu Hyon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230189790Abstract: A non-freezing refrigerated storage liquid for stem cells such as iPS cells, according to an embodiment, comprises: potassium ion species in a range of 30 to 80 mmoL/L; sodium ion species in a range of 30 to 80 mmoL/L, wherein ion-based molar ratio of sodium ion species to potassium ion species (ratio ofNa+ to K+) is in a range of 0.5 to 1.3; trolox or its analog at a concentration of 1 to 8 mM; adenine or a salt or derivative thereof at a concentration of 0.1 to 4.2 mM; all of or all but one, two or three of essential amino acids, total content of which is 50 to 200 mg; and non-essential amino acids, total content of which is 50 to 200 mg/L.Type: ApplicationFiled: November 5, 2020Publication date: June 22, 2023Applicant: BIOVERDE INC.Inventors: Akira AIZAWA, Suong-Hyu HYON, Woogi HYON
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Patent number: 11659833Abstract: Provided are a vehicle body assembling method and a vehicle body assembling apparatus which allow a simple configuration in the vicinity of the connecting portion between an upper jig and a lower jig and allow an increase in the efficiency of assembling work (welding work). A vehicle body assembling apparatus is equipped with a jig for supporting vehicle body components in a preassembled position, the jig comprising an upper jig and a lower jig which are connected to each other in at least two places. Each of the connection places is provided with a connecting means for fixing a three-dimensional coordinate position while allowing uniaxial turning. The vehicle body assembling apparatus is also equipped with a conveying means for conveying the upper jig which supports the vehicle body components, and reduces the load applied to the lower jig from the upper jig when connecting the upper jig to the lower jig.Type: GrantFiled: August 22, 2017Date of Patent: May 30, 2023Assignee: BioVerde Inc.Inventors: Chikara Kubota, Takaaki Ando, Suong-Hyu Hyon, Woogi Hyon, Shuji Imamura, Satoru Gessei
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Publication number: 20220386592Abstract: Provided are a cryopreservation liquid for bovine reproductive cells such as bovine sperms and a cryopreservation method thereof. Adopted is a cryopreservation liquid comprising: 0.3 to 0.9 w/w % of an amphoteric polyelectrolyte (an antifreeze polyamino acid), which is ?-poly-L-lysine having a number average molecular weight of 1,000 to 20,000 wherein 50 to 99 mol % of amino groups of the ?-poly-L-lysine are blocked as carboxylated by having been reacted with the succinic anhydride; and 2 to 4 w/w % of glycerol, as dissolved in a physiological solution. A preferred embodiment of the cryopreservation method comprises steps of: primary diluting, in which bovine semen is diluted to 2.5 to 10 times with a physiological solution and kept at 2 to 8° C.; and secondary diluting, in which the bovine semen is diluted to 5 to 20 times while being kept at 2 to 8° C.Type: ApplicationFiled: August 5, 2022Publication date: December 8, 2022Inventors: Chikara Kubota, Takaaki Ando, Suong-Hyu Hyon, Woogi Hyon, Shuji Imamura, Satoru Gessei
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Patent number: 11471141Abstract: A powder spray device includes a funnel member, a first three-way joint, an air-current supply tube, a discharge tube, a vibration motor, a bypass air-current tube, and a switching mechanism. The first three-way joint has a first opening connected to an outlet at a lower end of the funnel member. The air-current supply tube and discharge tube are respectively connected to second and third openings of the first three-way joint. The vibration motor is fixed onto an outer surface of a funnel body of the funnel member. The bypass air-current tube branches off from the air-current supply tube and is connected to the discharge tube. The switching mechanism switches from and to standby state, in which compressed gas is sent only through the bypass air-current tube, to and from spray-coating state, in which compressed gas is sent out through the air-current supply tube, and also through the bypass air-current tube.Type: GrantFiled: June 5, 2020Date of Patent: October 18, 2022Assignee: BMG INCORPORATEDInventors: Motoki Fujimura, Shinichi Osada, Yusuke Kojitani, Woogi Hyon, Suong-Hyu Hyon
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Publication number: 20220016311Abstract: A sheet-shaped tissue adhesive/reinforcement includes a base sheet having biodegradability and a communicative porous structure, and an adhesive resin layer fixed and formed on the base sheet. The adhesive resin layer includes a first reactant made of an aldehyded glycan and a second reactant made of partially carboxylated polylysine, and has a molar ratio of 1 as a ratio of an aldehyde group of the first reactant to an amine group of the second reactant. The adhesive resin layer has a structure of granules derived from powder of the first reactant, and a connecting layer derived from the second reactant. The connecting layer connects the granules to each other and fixes each of the granules onto the base sheet, throughout the sheet-shaped tissue adhesive/reinforcement.Type: ApplicationFiled: December 9, 2019Publication date: January 20, 2022Inventors: Shuhei TANIDA, Motoki FUJIMURA, Yusuke KOJITANI, Shinichi OSADA, Woogi HYON, Suong-Hyu HYON
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Publication number: 20210378649Abstract: A powder spray device includes a funnel member, a first three-way joint, an air-current supply tube, a discharge tube, a vibration motor, a bypass air-current tube, and a switching mechanism. The first three-way joint has a first opening connected to an outlet at a lower end of the funnel member. The air-current supply tube and discharge tube are respectively connected to second and third openings of the first three-way joint. The vibration motor is fixed onto an outer surface of a funnel body of the funnel member. The bypass air-current tube branches off from the air-current supply tube and is connected to the discharge tube. The switching mechanism switches from and to standby state, in which compressed gas is sent only through the bypass air-current tube, to and from spray-coating state, in which compressed gas is sent out through the air-current supply tube, and also through the bypass air-current tube.Type: ApplicationFiled: June 5, 2020Publication date: December 9, 2021Inventors: Motoki FUJIMURA, Shinichi OSADA, Yusuke KOJITANI, Woogi HYON, Suong-Hyu HYON
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Publication number: 20190174742Abstract: Provided are a vehicle body assembling method and a vehicle body assembling apparatus which allow a simple configuration in the vicinity of the connecting portion between an upper jig and a lower jig and allow an increase in the efficiency of assembling work (welding work). A vehicle body assembling apparatus is equipped with a jig for supporting vehicle body components in a preassembled position, the jig comprising an upper jig and a lower jig which are connected to each other in at least two places. Each of the connection places is provided with a connecting means for fixing a three-dimensional coordinate position while allowing uniaxial turning. The vehicle body assembling apparatus is also equipped with a conveying means for conveying the upper jig which supports the vehicle body components, and reduces the load applied to the lower jig from the upper jig when connecting the upper jig to the lower jig.Type: ApplicationFiled: August 22, 2017Publication date: June 13, 2019Inventors: Chikara Kubota, Takaaki Ando, Suong-Hyu Hyon, Woogi Hyon, Shuji Imamura, Satoru Gessei
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Patent number: 9826732Abstract: A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In embodiments, ?-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In embodiments for foods or pharmaceuticals, the ?-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration.Type: GrantFiled: June 30, 2016Date of Patent: November 28, 2017Assignee: Bio Verde Inc.Inventors: Kazuaki Matsumura, Hajime Sugai, Suong-Hyu Hyon
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Patent number: 9603355Abstract: A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In embodiments, ?-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In embodiments for foods or pharmaceuticals, the ?-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration.Type: GrantFiled: April 30, 2014Date of Patent: March 28, 2017Assignee: BIO VERDE INC.Inventors: Kazuaki Matsumura, Hajime Sugai, Suong-Hyu Hyon
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Publication number: 20160309706Abstract: A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In embodiments, ?-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In embodiments for foods or pharmaceuticals, the ?-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration.Type: ApplicationFiled: June 30, 2016Publication date: October 27, 2016Inventors: Kazuaki MATSUMURA, Hajime SUGAI, Suong-Hyu HYON
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Publication number: 20140243426Abstract: A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In embodiments, ?-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In embodiments for foods or pharmaceuticals, the ?-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration.Type: ApplicationFiled: April 30, 2014Publication date: August 28, 2014Applicant: Bio Verde Inc.Inventors: Kazuaki MATSUMURA, Hajime SUGAI, Suong-Hyu HYON
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Publication number: 20110172315Abstract: A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In examples, ?-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In examples for foods or pharmaceuticals, the ?-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration.Type: ApplicationFiled: June 26, 2009Publication date: July 14, 2011Applicant: Bio Verde. Inc.Inventors: Kazuaki Matsumura, Hajime Sugai, Suong-Hyu Hyon
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Patent number: 7834065Abstract: Medical-use two-part adhesive comprising; first part comprised of an aqueous solution or a powder of aldehyde-groups-introduced alpha-glucan; and second part comprised of an aqueous solution or a powder of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000; as well as medical-use hydrogel resin obtained by curing the adhesive. A mixture of the first and second parts, at a time of mixing them to form the hydrogel has pH in a range of 5.0 to 8.0. In a preferred embodiment, the amino-groups-containing polymer is epsilon-poly-L-lysine produced by microorganism or by enzyme.Type: GrantFiled: July 30, 2007Date of Patent: November 16, 2010Assignee: BMG IncorporatedInventors: Naoki Nakajima, Hajime Sugai, Masakazu Konda, Suong-Hyu Hyon
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Patent number: 7683106Abstract: A dental material primer and a dentin-regenerating pulp-capping agent which exhibit an excellent dentin-regenerating action, are disclosed. The dental material primer includes a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized and the dentin-regenerating pulp-capping agent includes a hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, and a binder.Type: GrantFiled: March 5, 2004Date of Patent: March 23, 2010Assignee: Nippon Synthetic Chemical Industry Co., Ltd.Inventors: Masahiro Yoshiyama, Yoshihiro Nishitani, Sadami Tsutsumi, Suong-Hyu Hyon
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Publication number: 20090170929Abstract: The present invention provides a composition for efficiently protecting and preserving organs, tissues or cells. In particular, the present invention provides a protective composition which can be used during operations. Specifically, the present invention provides a composition for protecting and preserving organs, tissues or cells, comprising a polyphenol. A method is also provided for protecting an organ, tissue or cell in a subject, comprising 1) exposing the organ, tissue or cell to a polyphenol. Such a composition and a polyphenol is effective in protecting a function of an organ (particularly, the heart, brain, nerve, spinal cord and the like).Type: ApplicationFiled: March 3, 2009Publication date: July 2, 2009Applicants: BMG IncorporatedInventors: Masashi Komeda, Suong-Hyu Hyon, Senri Miwa
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Publication number: 20080319101Abstract: Medical-use two-part adhesive comprising; first part comprised of an aqueous solution or a powder of aldehyde-groups-introduced alpha-glucan; and second part comprised of an aqueous solution or a powder of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000; as well as medical-use hydrogel resin obtained by curing the adhesive. A mixture of the first and second parts, at a time of mixing them to form the hydrogel has pH in a range of 5.0 to 8.0. In a preferred embodiment, the amino-groups-containing polymer is epsilon-poly-L-lysine produced by microorganism or by enzyme.Type: ApplicationFiled: July 30, 2007Publication date: December 25, 2008Applicant: BMG IncorporatedInventors: Naoki Nakajima, Hajime Sugai, Masakazu Konda, Suong-Hyu Hyon
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Publication number: 20080145440Abstract: According to the present invention, an early-phase release amount of cisplatin (CCDP) is reduced and a release of cisplatin is maintained over a long period of time, such that an anticancer effect against cancer cells is enhanced while side effects are reduced. In this manner, a life prolongation effect for patients is enhanced. A microparticle preparation contains cisplatin that is intercalated into double-helical DNA. The microparticle preparation stably retains cisplatin and exhibits an excellent slow-release property. Accordingly, even when cisplatin containing severe toxicity is used, the side effects can be suppressed and an excellent anticancer effect can be provided over a long period of time.Type: ApplicationFiled: June 19, 2007Publication date: June 19, 2008Applicants: NISSEI BIO COMPANY, LIMITED, Suong Hyu HyonInventors: Han Hee Cho, Long Hai Han, Kazuaki Matsumura, Sadami Tsutsumi, Suong Hyu Hyon, Masaji Matsunaga, Fumihito Yoshida
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Patent number: 7323211Abstract: It is to provide an implant with shock-absorbing property that is able to be strongly secured in a living body as well as a manufacturing method of such implant. The implant comprising: a substrate; a first film on the substrate, which is comprised of a polymer and has a functional group that enables adsorption of calcium ions; and a second film formed on the first film and being comprised of calcium phosphate. The manufacturing method of the implant comprising: forming said first film on a substrate; and subsequently, dipping the substrate in a calcium ion solution and in a phosphate ion solution alternately as to form the second film.Type: GrantFiled: May 13, 2004Date of Patent: January 29, 2008Assignee: BMG IncorporatedInventors: Suong-Hyu Hyon, Kazuaki Matsumura, Sadami Tsutsumi
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Publication number: 20070259327Abstract: A cryopreservation medium and a cryopreservation method which make it possible to cryopreserve tissues and cells with high viability are provided. A cryopreservation medium contains polyphenol at a concentration of from 30 to 120 ppm. In an embodiment, a cryopreservation method for tissues and cells comprises: incubating tissues or cells for 2 hours in culture medium supplemented with polyphenol at concentrations of from 30 to 120 ppm; suspending tissues or cells in a cryopreservation medium; freezing the suspension of the tissues or cells in the cryopreservation medium; and storing the frozen suspension of tissues or cells in the cryopreservation medium.Type: ApplicationFiled: May 3, 2006Publication date: November 8, 2007Applicant: BioVerde. Inc.Inventors: Yasuhiro Iwanaga, Kazuaki Matsumura, Jong-Yoon Kim, Hajime Sugai, Suong-Hyu Hyon
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Patent number: RE44762Abstract: An ultra high molecular weight polyethylene molded article for artificial joints has molecular orientation or crystal orientation in the molded article, and is low in friction and is superior in abrasion resistance, and therefore is available as components for artificial joints. Further, the ultra high molecular weight polyethylene molded article for artificial joints can be used as a component for artificial hip joints (artificial acetabular cup), a component for artificial knee joints (artificial tibial insert) and the socket for artificial elbow joints, and in addition to the medical use, it can be applied as materials for various industries by utilizing the characteristics such as low friction and superior abrasion resistance.Type: GrantFiled: June 22, 2012Date of Patent: February 11, 2014Assignee: BMG IncorporatedInventors: Suong-Hyu Hyon, Hiroki Takahashi