Patents by Inventor SuPing Lyu
SuPing Lyu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10442757Abstract: A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.Type: GrantFiled: May 7, 2018Date of Patent: October 15, 2019Assignee: Medtronic, Inc.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
-
Publication number: 20190292327Abstract: A poly(ether-carbonate)-based polymer and a medical device that includes such polymer, wherein the poly(ether-carbonate)-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments include poly(ether-carbonate) residues and at least one of polyisobutylene (PIB) residues and hydrogenated polybutadiene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: ApplicationFiled: March 20, 2019Publication date: September 26, 2019Inventors: Kimberly A. CHAFFIN, Xiangji CHEN, Matthew JOLLY, SuPing LYU, Peter L. THOR, Darrel F. UNTEREKER, Zhaoxu WANG
-
Publication number: 20190292302Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: ApplicationFiled: March 20, 2019Publication date: September 26, 2019Inventors: Kimberly A. CHAFFIN, Xiangji CHEN, Matthew JOLLY, SuPing LYU, Peter L. THOR, Darrel F. UNTEREKER, Zhaoxu WANG
-
Patent number: 10406268Abstract: Monitoring of the performance of a blood fluid removal medium of a blood fluid removal device includes monitoring of condition, such as fluid flow rate or concentration of blood waste product, downstream of the medium. Upstream monitoring of the condition may also be performed to enhance the ability to determine whether the blood fluid removal medium is performing within predetermined ranges.Type: GrantFiled: March 11, 2016Date of Patent: September 10, 2019Assignee: Medtronic, Inc.Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
-
Patent number: 10384050Abstract: An implantable medical leads has a conductor that includes one or more metal wires and one or more carbon nanotube wires extending in substantially the same direction as the one or more metal wires. Such conductors may result in less MRI-induced heating at electrodes of leads than conductors that do not contain carbon nanotubes.Type: GrantFiled: June 24, 2015Date of Patent: August 20, 2019Assignee: MEDTRONIC, INC.Inventors: Mallika Kamarajugadda, Mark Breyen, Suping Lyu, Bernard Q. Li, Qin Zhang, Jacob Popp
-
Patent number: 10293092Abstract: Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.Type: GrantFiled: August 18, 2015Date of Patent: May 21, 2019Assignee: MEDTRONIC, INC.Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
-
Publication number: 20190111186Abstract: A medical device, a method for preparation thereof, and use thereof are provided. The medical device comprises a thermoplastic elastomer that is composed of soft segments and hard segments. The method for preparing a medical device comprising a thermoplastic elastomer, comprises forming the thermoplastic elastomer into tubing or other shapes via extrusion, molding, or coating, assembling the tubing or other shapes with other parts including: cables, coils, coated cables, or coated coils, and bonding the tubing, cables, or coils with other components including: other tubing components, cables, coils, sleeves, electrical pulse generator, defibrillation shock generator, electrodes, sensors, or drug release components. The medical device is used for correcting cardiac rhythm, defibrillating, assisting hearts, sensing, stimulating neurological systems, gastrointestinal system, or skeletomuscular tissues or organs.Type: ApplicationFiled: March 2, 2017Publication date: April 18, 2019Inventors: Suping LYU, XiangJi CHEN, Jing CHEN, Haining NA, Jin ZHU
-
Publication number: 20190112411Abstract: Disclosed is a segmented thermoplastic elastomer that can be a polyurethane, polyurea, or polyurethane-urea comprising soft segments and hard segments, wherein the soft segments are made of polyolefin diols or polyolefin diamine that may have 0 to 1000 carbon atoms in the main chain, wherein each carbon atom in the main chain may have 0 to 2 side chains and each side chain may have 0 to 30 carbon atoms, the hard segment is made of a diisocyante and a chain extender, the hard segments make up 10-60% of the elastomer and the soft segments make up the rest, the number-average molecular weight of the elastomer is 5×103-1000×103 g/mol, the ultimate elongation of the elastomer is 100-1000%, the Young's modulus is 1 to 3,000 MPa, and the ultimate tensile strength is 10-100 MPa. Also disclosed are a method for preparing the segmented thermoplastic elastomer and use of segmented thermoplastic elastomer.Type: ApplicationFiled: March 2, 2017Publication date: April 18, 2019Inventors: Jing CHEN, Haining NA, Jin ZHU, Suping LYU, XiangJi CHEN
-
Patent number: 10179198Abstract: Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.Type: GrantFiled: August 18, 2015Date of Patent: January 15, 2019Assignee: MEDTRONIC, INC.Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
-
Publication number: 20180355104Abstract: A method for hydrogenating tyrosine derived polyarylates includes dissolving a second polyarylate with DMF in a flask to produce a first solution. A catalyst is added to the first solution to produce a polymer solution. The polymer solution is filtered through a Celite bed to produce a filtrate. The filtrate is added to water and stirred to precipitate the polyarylate.Type: ApplicationFiled: May 7, 2018Publication date: December 13, 2018Applicant: Tyrx, Inc.Inventors: SATISH PULAPURA, DAN THANH LE, XIANGJI CHEN, SUPING LYU, FATIMA BUEVICH
-
Publication number: 20180354892Abstract: A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCl HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.Type: ApplicationFiled: May 7, 2018Publication date: December 13, 2018Applicant: TYRX, Inc.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
-
Publication number: 20180355103Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.Type: ApplicationFiled: May 7, 2018Publication date: December 13, 2018Applicant: TYRX, Inc.Inventors: SATISH PULAPURA, FATIMA BUEVICH, XIANGJI CHEN, SUPING LYU
-
Patent number: 10064985Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.Type: GrantFiled: December 20, 2016Date of Patent: September 4, 2018Assignee: Medtronic, Inc.Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
-
Patent number: 10040021Abstract: Frame structures, assemblies and methods for use in implantable medical devices. The frames may include one or more first polymeric portions and one or more second polymeric portions coupled to the one or more first polymeric portions. The one or more first polymeric portions may have a higher durometer than the one or more second polymeric portions. The one or more second polymeric portions may provide an interference fit between the one or more second polymeric portions and the housing and/or between the one or more second polymeric portions and one or more components disposed in the housing.Type: GrantFiled: January 9, 2015Date of Patent: August 7, 2018Assignee: Medtronic, Inc.Inventors: Andrew J. Ries, SuPing Lyu, Catherine M. Asgian, David Engmark, Ananta Pandey, Todd Schaefer, Erik Scott, Joachim Hossick-Schott
-
Patent number: 9974896Abstract: Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include passing solutions containing combinations of acids, bases and salts through a module containing a rechargeable sorbent material such as zirconium phosphate in order to replace ions bound to the zirconium phosphate with hydrogen and sodium ions. The method allows for a customizable zirconium phosphate, with control over the ratios of sodium to hydrogen on the recharged zirconium phosphate.Type: GrantFiled: March 10, 2015Date of Patent: May 22, 2018Assignee: Medtronic, Inc.Inventors: Bryant J. Pudil, SuPing Lyu, Eric Grovender, Christopher M. Hobot, Martin T. Gerber
-
Patent number: 9968721Abstract: A method includes monitoring an indicator of fluid volume of a patient via a sensor device, and setting an initial fluid volume removal prescription for a blood fluid removal session based on the monitored indicator of fluid volume. The method may further include transmitting data regarding the indicator of fluid volume from the implantable sensor device to fluid removal device. The system includes a blood fluid removal device and control electronics configured to set the initial fluid removal volume and rate prescription. In some embodiments, the fluid removal device sets or calculated the initial fluid volume removal prescription based on the data received from the implantable sensor. The indicator of fluid volume may be an indicator of tissue fluid volume or an indicator of blood fluid volume.Type: GrantFiled: November 26, 2014Date of Patent: May 15, 2018Assignee: MEDTRONIC, INC.Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
-
Publication number: 20170361006Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.Type: ApplicationFiled: September 1, 2017Publication date: December 21, 2017Inventors: Martin Gerber, John Burnes, SuPing Lyu, VenKatesh R. Manda, Bryant Pudil
-
Patent number: 9750862Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.Type: GrantFiled: March 20, 2012Date of Patent: September 5, 2017Assignee: Medtronic, Inc.Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
-
Patent number: 9707330Abstract: Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled.Type: GrantFiled: August 22, 2012Date of Patent: July 18, 2017Assignee: Medtronic, Inc.Inventors: Thomas D. Kelly, SuPing Lyu
-
Patent number: 9700661Abstract: Methods include monitoring blood pH or electrolyte levels and setting initial fluid parameters, such as dialysate fluid parameters or replacement fluid parameters, for a blood fluid removal session based the monitored data. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.Type: GrantFiled: March 20, 2012Date of Patent: July 11, 2017Assignee: Medtronic, Inc.Inventors: Martin Gerber, Suping Lyu, Bryant Pudil