Patents by Inventor Suresh R. Kapadia

Suresh R. Kapadia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for making oxetan-3-ylmethanamines
    Patent number: 9376409
    Abstract: This invention relates to methods for making oxetan-3-ylmethanamines having the formula (I) wherein R1? and R2? are as defined herein. The methods of the invention provide the compounds of formula (I) in high yields and under conditions amenable for large-scale commercial production.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: June 28, 2016
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Magnus Carl Arne Eriksson, Suresh R. Kapadia, Jonathan Timothy Reeves, Xingzhong Zeng
  • METHODS FOR MAKING OXETAN-3-YLMETHANAMINES
    Publication number: 20150119589
    Abstract: This invention relates to methods for making oxetan-3-ylmethanamines having the formula (I) wherein R1? and R2? are as defined herein. The methods of the invention provide the compounds of formula (I) in high yields and under conditions amenable for large-scale commercial production.
    Type: Application
    Filed: May 1, 2013
    Publication date: April 30, 2015
    Inventors: Magnus Carl Arne Eriksson, Suresh R. Kapadia, Jonathan Timothy Reeves, Xingzhong Zeng
  • Benzodioxane inhibitors of leukotriene production
    Patent number: 8946203
    Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: February 3, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Asitha Abeywardane, Steven Richard Brunette, Michael J. Burke, Suresh R. Kapadia, Thomas Martin Kirrane, Matthew Russell Netherton, Hossein Razavi, Sonia Rodriguez, Anjan Saha, Robert Sibley, Lana Louise Smith-Keenan, Hidenori Takahashi, Michael Robert Turner, Jiang-Ping Wu, Erick Richard Roush Young, Qiang Zhang, Qing Zhang, Renee M. Zindell
  • BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION
    Publication number: 20130244996
    Abstract: The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 19, 2013
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Asitha ABEYWARDANE, Steven Richard BRUNETTE, Michael J. BURKE, Suresh R. KAPADIA, Thomas Martin KIRRANE, Matthew Russell NETHERTON, Hossein RAZAVI, Sonia RODRIGUEZ, Anjan SAHA, Robert SIBLEY, Lana Louise SMITH-KEENAN, Hidenori TAKAHASHI, Michael Robert TURNER, Jiang-Ping WU, Erick Richard Roush YOUNG, Qiang ZHANG, Qing ZHANG, Renee M. ZINDELL
  • Process for preparing macrocyclic compounds
    Patent number: 8222369
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: July 17, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Fabrice Gallou, Nizar Haddad, Azad Hossain, Suresh R. Kapadia, Jianxiu Liu, Chris H. Senanayake, Xudong Wei, Nathan K. Yee
  • Process for preparing acyclic HCV protease inhibitors
    Patent number: 8101765
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: January 24, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Rogelio Perez Frutos, Nizar Haddad, Suresh R. Kapadia, Jon Charles Lorenz, Anjan Saha, Chris Hugh Senanayake, Xudong Wei
  • Process for preparing acyclic HCV protease inhibitors
    Patent number: 8017771
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: September 13, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Rogelio Perez Frutos, Nizar Haddad, Suresh R. Kapadia, Jon Charles Lorenz, Anjan Saha, Chris Hugh Senanayake, Xudong Wei
  • PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS
    Publication number: 20090326194
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Application
    Filed: September 2, 2009
    Publication date: December 31, 2009
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan BUSACCA, Fabrice GALLOU, Nizar HADDAD, Azad HOSSAIN, Suresh R. KAPADIA, Jianxiu LIU, Chris SENANAYAKE, Xudong WEI, Nathan K. YEE
  • Process for preparing macrocyclic compounds
    Patent number: 7608614
    Abstract: Intermediates of the formula QUIN: and methods for their preparation are described. The intermediate compounds are useful for preparing active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: October 27, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Fabrice Gallou, Nizar Haddad, Azad Hossain, Suresh R. Kapadia, Jianxiu Liu, Chris Senanayake, Xudong Wei, Nathan K. Yee
  • PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS
    Publication number: 20090124808
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Application
    Filed: January 16, 2009
    Publication date: May 14, 2009
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Carl Alan BUSACCA, Rogelio Perez FRUTOS, Nizar HADDAD, Suresh R. KAPADIA, Jon Charles LORENZ, Anjan SAHA, Chris Hugh SENANAYAKE, Xudong WEI
  • PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS
    Publication number: 20090124809
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Application
    Filed: January 16, 2009
    Publication date: May 14, 2009
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Carl Alan BUSACCA, Rogelio Perez FRUTOS, Nizar HADDAD, Suresh R. KAPADIA, Jon Charles LORENZ, Anjan SAHA, Chris Hugh SENANAYAKE, Xudong WEI
  • Process for preparing acyclic HCV protease inhibitors
    Patent number: 7514557
    Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: April 7, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Rogelio Perez Frutos, Nizar Haddad, Suresh R. Kapadia, Jon Charles Lorenz, Anjan Saha, Chris Hugh Senanayake, Xudong Wei
  • Dipeptide synthesis
    Patent number: 7186827
    Abstract: Disclosed are processes of making dipeptide compounds of formula(I) as further described in the detailed description section:
    Type: Grant
    Filed: October 27, 2004
    Date of Patent: March 6, 2007
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Carl Alan Busacca, Nizar Haddad, Suresh R. Kapadia, Lana Smith Keenan, Jon Charles Lorenz, Chris Hugh Senanayake, Xudong Wei
  • Sulfonamide intermediates and methods of producing same
    Patent number: 6703525
    Abstract: Disclosed are intermediates of the formula (A) and methods of making same.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: March 9, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Suresh R. Kapadia, Jinhua J. Song, Nathan K. Yee
  • Synthesis of heteroarylamine intermediate compounds
    Patent number: 6635767
    Abstract: Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: October 21, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jinhua J. Song, Nathan K. Yee, Suresh R. Kapadia
  • Synthesis of heteroarylamine intermediate compounds
    Patent number: 6613909
    Abstract: Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: September 2, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jinhua J. Song, Nathan K. Yee, Suresh R. Kapadia
  • Synthesis for heteroarylamine compounds
    Patent number: 6603000
    Abstract: Disclosed is a novel method of producing heteroaryl amines of the formula(I): wherein X, Y and Z are described herein, the heteroarylamines are useful in the production of heteroaryl ureas which are key component in pharmaceutically active compounds possessing a heteroaryl urea group.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 5, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Nathan Yee, Suresh R. Kapadia, Jinhua J. Song
  • Synthesis of heteroarylamine intermediate compounds
    Patent number: 6593471
    Abstract: Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: July 15, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jinhua J. Song, Nathan K. Yee, Suresh R. Kapadia
  • Synthesis of heteroarylamine intermediate compounds
    Patent number: 6590099
    Abstract: Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: July 8, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jinhua J. Song, Nathan K. Yee, Suresh R. Kapadia
  • Sulfonamide intermediates and methods of producing same
    Publication number: 20030065034
    Abstract: Disclosed are intermediates of the formula (A) and methods of making same. The intermediate compounds are useful in the synthesis of heteroaryl/aryl urea compounds.
    Type: Application
    Filed: October 4, 2002
    Publication date: April 3, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Suresh R. Kapadia, Jinhua J. Song, Nathan K. Yee