Abstract: The invention relates to neurodegenerative disorders, and in particular to novel peptides, peptidomimetics, compositions, therapies and methods for treating such conditions, for example Alzheimer's disease.

Abstract: The invention provides a cyclic polypeptide, derivative or analogue thereof comprising an amino acid sequence derived from the C-terminus of acetylcholinesterase (AChE), or a truncation thereof, for use in treating, preventing or ameliorating Down's syndrome.

Abstract: The invention relates to animal models, and in particular to novel in vivo animal models for neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease or Motor Neurone Disease. The invention extends to methods for providing such models. The invention also provides animal models per se and methods for investigating the underlying mechanisms occurring in such neurodegenerative disorders, in particular, Alzheimer's disease, and also extends to models, methods and assays for testing pharmacological test compounds, which may modulate neurological processes, and for drug screening for use in treating neurodegenerative diseases.

Abstract: A cyclic polypeptide, derivative or analogue thereof, comprising an amino acid sequence derived from the C-terminus of acetylcholinesterase (AChE), or a truncation thereof.

Abstract: A cyclic polypeptide, derivative or analogue thereof, comprising an amino acid sequence derived from the C-terminus of acetylcholinesterase (ACh E), or a truncation thereof.

Abstract: The invention relates to neurodegenerative disorders, and in particular to novel peptides, peptidomimetics, compositions, therapies and methods for treating such conditions, for example Alzheimer's disease.

Abstract: The invention relates to biomarkers for neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease or Motor Neurone disease. The invention especially relates to a novel quantitative predictive biomarker for cognitive decline, and in particular the rate of cognitive decline that a subject will suffer, for example as a result of developing a neurode-generative disorder. The invention further provides diagnostic and prognostic methods, and kits for predicting the rate of cognitive decline in subjects.

Abstract: A cyclic polypeptide, derivative or analogue thereof, comprising an amino acid sequence derived from the C-terminus of acetylcholinesterase (ACh E), or a truncation thereof.

Abstract: The invention relates to cancer, and in particular to novel pharmaceutical compositions, therapies and methods for treating, preventing or ameliorating cancer, and especially metastatic disease. The invention also relates to diagnostic and prognostic methods for cancer and metastatic disease, and biomarkers for these conditions.

Abstract: A cyclic polypeptide, derivative or analog thereof, comprising an amino acid sequence derived from the C-terminus of acetylcholinesterase (ACh E), or a truncation thereof.

Abstract: A cyclic polypeptide, derivative or analogue thereof, comprising an amino acid sequence derived from the C-terminus of acetylcholinesterase (ACh E), or a truncation thereof.

Abstract: In a system including a display and a selection device, a method of providing and selecting multiple control panels on the display includes providing a user interface on the display. The user interface includes an object that has an axis and is user-scrollable about the axis to selectively bring each of the multiple control panels into and out of view.

Abstract: In a system including a display and a selection device, a method of providing and selecting multiple control panels on the display includes providing a user interface on the display. The user interface includes an object that has an axis and is user-scrollable about the axis to selectively bring each of the multiple control panels into and out of view.

Abstract: A method is provided that includes displaying a user interface on a display device. The user interface includes a first ring and a first menu. The first ring has an axis and is user-scrollable about the axis to selectively bring portions of the first menu into and out of sight. An item from the first menu is selected.

Abstract: In a system including a display and a selection device, a method of providing and selecting a history of user settings on the display is disclosed. The method includes providing a user interface on the display. The user interface includes a panel that has a list of system settings made by a user during a session. The items in the list are selectively enabled or disabled by user input.

Abstract: A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, (for example, tolbutamide), or quinine.

Abstract: A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, which neurons are prone to Parkinsonian degeneration by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.

Abstract: A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, which neurons are prone to Parkinsonian degeneration by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.

Abstract: A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, (for example, tolbutamide), or quinine.

Abstract: A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.