Abstract: Delivering cold slurry to internal tissues can be used in therapies for treating a variety or medical diseases and conditions. For example, cold slurry can activate brown adipose tissue to treat obesity. Cold slurry can be delivered to tissue injured by trauma or disease to reduce inflammation, which in turn reduces pain and leads to quicker recovery. Cold slurry therapy can also be used to treat muscular and neurological disorders as well as to manage pain. The cooling effect of cold slurry delivered at or near a nerve reduces innervation that nerve, which in turn reduces spasms or pain. The cooling effect can also cause tissue to undergo the cell death. Advantageously, cold slurry therapies can be used to reduce or remove tissue, for example, to treat fibroadenomas or scar tissue.