Abstract: The disclosure is directed to inhibitory agents that hybridize to a GAPLINC RNA and inhibit or reduce the expression of the GAPLINC RNA. The GAPLINC RNA is a long non-coding RNA (lncRNA) located on chromosome 18 between the protein-coding genes Tgif and Dlgap1. The disclosure also features pharmaceutical compositions including the inhibitory agents and methods of using the inhibitory agents to treat an inflammatory disease, such as sepsis.

Abstract: The disclosure is directed to inhibitory agents that hybridize to a GAPLINC RNA and inhibit or reduce the expression of the GAPLINC RNA. The GAPLINC RNA is a long non-coding RNA (lncRNA) located on chromosome 18 between the protein-coding genes Tgif and Dlgap1. The disclosure also features pharmaceutical compositions including the inhibitory agents and methods of using the inhibitory agents to treat an inflammatory disease, such as sepsis.

Abstract: A sports training and guidance platform network which intertwine various wearables is provided. The network includes at least one wearable containing one biosensor worn on the body, and input from a data stream, analytics and accessed on mobile devices. According to this aspect, the wearable network will measure and compare individual or team performance with various biosensor data, and motion i.e., accelerometers, gyroscopes. A sports training toolkit which includes the wearable communication network and platform and system is also provided.

Abstract: Systems and methods for systems and platforms that receive data from and send data to wearable devices, receive data from environmental sensors, and visualization which collectively creates a kinematic chain to allow for input from individuals, groups, third party information and interfaces with historical data as well as predictive modeling systems. Systems that include data from interoperable wearables in conjunction with one or more sensors and measuring devices may be used. Furthermore, the interoperability of one or more sensors and communication modules could be networked with one or more physical entities and objects creating an interactive communication network. Wearable platforms could include but are not limited to all wearables (inter- and intra- and proximity-wearables), smart devices, IT networks, virtual systems and secure information processes.

Abstract: The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the suppression Toll-like Receptor 4 mediated activation of the immune system. The invention further provides screening assays to identify compounds which have utility in the foregoing compositions and methods.

Abstract: The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the suppression of Toll-like Receptor 14 interaction with CD14 during Toll-like Receptor mediated signalling. The invention further provides screening assays to identify compounds which have utility in preventing the association of Toll-like Receptor 14 and CD14.

Abstract: The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the suppression Toll-like Receptor 4 mediated activation of the immune system. The invention further provides screening assays to identify compounds which have utility in the foregoing compositions and methods.

Abstract: The operating lifetime of a hot cathode discharge ion source is extended by introducing nitrogen into an ion implantation apparatus after introduction of an ion implantation gas, such as GeF4, is stopped. The nitrogen is preferably introduced along with the GeF4 during implantation as well.