Patents by Inventor Susan J. Braunhut
Susan J. Braunhut has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11150236Abstract: In an embodiment, a system includes a plurality of sensor devices contained in a plurality of wells contained in a well-plate assembly. The sensor devices are used in a plurality of oscillators. Each oscillator generates a frequency and a resistance based on a quality of living biological cells contained in a corresponding well. The quality may include, for example, surface coupled mass, density, viscosity, and/or viscoelasticity of the living biological cells. The system also includes logic for measuring a resonant frequency and motional resistance associated with each sensor device and logic for processing the measured resonant frequency and motional resistance. Moreover, the system includes logic for displaying one or more graphs showing one or more characteristics of the living biological cells contained in the wells.Type: GrantFiled: February 17, 2017Date of Patent: October 19, 2021Assignee: University of MassachusettsInventors: Abiche H. Dewilde, Berk Akinci, Joel M. Therrien, Kenneth A. Marx, Susan J. Braunhut
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Publication number: 20170241982Abstract: In an embodiment, a system includes a plurality of sensor devices contained in a plurality of wells contained in a well-plate assembly. The sensor devices are used in a plurality of oscillators. Each oscillator generates a frequency and a resistance based on a quality of living biological cells contained in a corresponding well. The quality may include, for example, surface coupled mass, density, viscosity, and/or viscoelasticity of the living biological cells. The system also includes logic for measuring a resonant frequency and motional resistance associated with each sensor device and logic for processing the measured resonant frequency and motional resistance. Moreover, the system includes logic for displaying one or more graphs showing one or more characteristics of the living biological cells contained in the wells.Type: ApplicationFiled: February 17, 2017Publication date: August 24, 2017Inventors: Abiche H. Dewilde, Berk Akinci, Joel M. Therrien, Kenneth A. Marx, Susan J. Braunhut
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Publication number: 20140087451Abstract: In one embodiment according to the invention, there is provided a method of sensing a response of a living cell or virus to a change in conditions. The method comprises applying an essentially constant external electromotive force that causes oscillation of an acoustic wave device at essentially constant amplitude and frequency under steady state conditions. The acoustic wave device has attached at least one living cell or virus. A combined oscillating system including the acoustic wave device and the living cell or virus exhibits a fundamental frequency and at least one harmonic frequency of the combined oscillating system.Type: ApplicationFiled: August 20, 2013Publication date: March 27, 2014Applicant: University of MassachusettsInventors: Joel M. Therrien, Susan J. Braunhut, Kenneth A. Marx, Gang Wang, Malavika Vashist, Abiche H. Dewilde, Jianping Zhang, Hongwei Sun, Lian Dai, Sai Liu
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Publication number: 20120258444Abstract: In one embodiment according to the invention, there is provided a method of sensing a response of a living cell or virus to a change in conditions. The method comprises applying an essentially constant external electromotive force that causes oscillation of an acoustic wave device at essentially constant amplitude and frequency under steady state conditions. The acoustic wave device has attached at least one living cell or virus. A combined oscillating system including the acoustic wave device and the living cell or virus exhibits a fundamental frequency and at least one harmonic frequency of the combined oscillating system.Type: ApplicationFiled: November 18, 2011Publication date: October 11, 2012Inventors: Joel M. Therrien, Susan J. Braunhut, Kenneth A. Marx, Gang Wang, Malavika Vashist, Abiche H. Dewilde, Jianping Zhang, Hongwei Sun, Lian Dai, Sai Liu
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Patent number: 8143308Abstract: A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.Type: GrantFiled: October 29, 2007Date of Patent: March 27, 2012Assignees: University of Massachusetts Lowell, The United States of America, as represented by the Secretary of the ArmyInventors: Ferdinando F. Bruno, Jayant Kumar, Subhalakshmi Nagarajan, Susan J. Braunhut, Ramaswamy Nagarajan, Lynne A. Samuelson, Donna McIntosh, Klaudia Foley
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Patent number: 7566531Abstract: Selective whole cell QCM biosensors are disclosed. Also disclosed are methods of making and using such whole cell QCM biosensors, e.g., to screen drugs and diagnose diseases.Type: GrantFiled: March 3, 2004Date of Patent: July 28, 2009Assignee: University of MassachusettsInventors: Kenneth A. Marx, Susan J. Braunhut, Tiean Zhou, Anne Rugh
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Publication number: 20090170928Abstract: A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.Type: ApplicationFiled: October 29, 2007Publication date: July 2, 2009Inventors: Ferdinando F. Bruno, Jayant Kumar, Subhalakshmi Nagarajan, Susan J. Braunhut, Ramaswamy Nagarajan, Lynne A. Samuelson, Donna McIntosh, Klaudia Foley
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Patent number: 6997863Abstract: Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.Type: GrantFiled: July 19, 2002Date of Patent: February 14, 2006Assignee: Triton BioSystems, Inc.Inventors: Erik S. Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman, Susan J. Braunhut, Douglas U. Gwost, Blair Ardman
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Publication number: 20040235198Abstract: Selective whole cell QCM biosensors are disclosed. Also disclosed are methods of making and using such whole cell QCM biosensors, e.g., to screen drugs and diagnose diseases.Type: ApplicationFiled: March 3, 2004Publication date: November 25, 2004Inventors: Kenneth A. Marx, Susan J. Braunhut, Tiean Zhou, Anne Rugh
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Publication number: 20040072294Abstract: The invention features improved methods of and apparatus for generating and administering treatment dosages of morphogens mobilized from extracellular matrices (ECM) for tissue reconstruction applications. In particular, the invention provides tissue reconstruction devices and methods that stimulate EDMs, e.g., by applying an electric potential, to achieve controlled release of morphogens that can then be placed into tissue sites when needed. Selectively releasing different morphogens at different times by the application of specific stimuli accelerates the tissue reconstruction process.Type: ApplicationFiled: June 19, 2003Publication date: April 15, 2004Inventors: Susan J. Braunhut, Kenneth A. Marx, Tiean Zhou, Anne Rugh
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Publication number: 20030032995Abstract: Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.Type: ApplicationFiled: July 19, 2002Publication date: February 13, 2003Applicant: Triton Biosystems, Inc.Inventors: Erik S. Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman, Susan J. Braunhut, Douglas U. Gwost, Blair Ardman
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Publication number: 20030008335Abstract: The Quartz Crystal Microbalance (QCM) creates a piezoelectric biosensor utilizing living endothelial cells (ECs) as the biological signal transduction element. ECs adhere to the hydrophilically treated gold QCM surface under growth media containing serum. The EC QCM biosensor can be used for the study of EC attachment and to detect EC cytoskeletal alterations. The cellular biosensor can be used for real time identification or screening of classes of biologically active drugs or biological macromolecules that affect cellular attachment, regardless of their molecular mechanism of action.Type: ApplicationFiled: May 13, 2002Publication date: January 9, 2003Inventors: Kenneth A. Marx, Susan J. Braunhut, Tiean Zhou, Anne Montrone