Patents by Inventor Susan L. Elrod

Susan L. Elrod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for increasing hemoprotein production in filamentous fungi
    Patent number: 6261827
    Abstract: The present invention relates to methods of producing hemoproteins comprising (a) introducing into a filamentous fungal cell, which is capable of producing the hemoprotein, (i) one or more first control sequences capable of directing the expression of a heme biosynthetic enzyme encoded by a first nucleic acid sequence endogenous to the filamentous fungal cell, wherein the one or more of the first control sequences are operably linked to the first nucleic acid sequence; and/or (ii) one or more copies of one or more second nucleic acid sequences encoding a heme biosynthetic enzyme; (b) cultivating the filamentous fungal cell in a nutrient medium suitable for production of the hemoprotein and the heme biosynthetic enzymes; and (c) recovering the hemoprotein from the nutrient medium of the filamentous fungal cell.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: July 17, 2001
    Assignee: Novozymes Biotech, Inc.
    Inventors: Susan L. Elrod, Joel R. Cherry, Aubrey Jones
  • Polypeptides having uroporphyrinogen decarboxylase activity and nucleic acids encoding same
    Patent number: 6200795
    Abstract: The present invention relates to isolated polypeptides having uroporphyrinogen decarboxylase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: March 13, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventor: Susan L. Elrod
  • Method for increasing hemoprotein production in filamentous fungi
    Patent number: 6100057
    Abstract: The present invention relates to methods of producing hemoproteins comprising (a) introducing into a filamentous fungal cell, which is capable of producing the hemoprotein, (i) one or more first control sequences capable of directing the expression of a heme biosynthetic enzyme encoded by a first nucleic acid sequence endogenous to the filamentous fungal cell, wherein the one or more of the first control sequences are operably linked to the first nucleic acid sequence; and/or (ii) one or more copies of one or more second nucleic acid sequences encoding a heme biosynthetic enzyme; (b) cultivating the filamentous fungal cell in a nutrient medium suitable for production of the hemoprotein and the heme biosynthetic enzymes; and (c) recovering the hemoprotein from the nutrient medium of the filamentous fungal cell.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: August 8, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Susan L. Elrod, Joel R. Cherry, Aubrey Jones
  • Aspergillus oryzae 5-aminolevulinic acid synthases and nucleic acids encoding same
    Patent number: 5958747
    Abstract: The present invention relates to Aspergillus oryzae 5-aminolevulinic acid synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the 5-aminolevulinic acid synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the 5-aminolevulinic acid synthases.
    Type: Grant
    Filed: February 5, 1998
    Date of Patent: September 28, 1999
    Assignee: Novo Nordisk Biotech, Inc
    Inventors: Susan L. Elrod, Joel R. Cherry
  • Methods for producing polypeptides in respiratory-deficient cells
    Patent number: 5891669
    Abstract: The present invention relates to methods of producing a polypeptide, comprising: (a) introducing into a respiratory-defective mutant of a cell (i) one or more first nucleic acid sequences which complement the respiratory defect and (ii) a second nucleic acid sequence which encodes the polypeptide; (b) cultivating the cell containing the first and second nucleic acid sequences in a culture medium under aerobic conditions suitable for expression of the first and second nucleic acid sequences; and (c) isolating the polypeptide from the cultivation medium of the cell. The present invention also relates to methods for disrupting a gene in a respiratory-deficient mutant cell. The present invention further relates to respiratory-deficient mutant cells and methods for obtaining such mutant cells.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: April 6, 1999
    Assignees: Novo Nordisk A/S, Novoalle,, Novo Nordisk Biotech
    Inventors: Ejner Bech Jensen, Joel R. Cherry, Susan L. Elrod
  • Aspergillus oryzae 5-aminolevulinic acid synthases and nucleic acids encoding same
    Patent number: 5871991
    Abstract: The present invention relates to Aspergillus oryzae 5-aminolevulinic acid synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the 5-aminolevulinic acid synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the 5-aminolevulinic acid synthases.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: February 16, 1999
    Assignee: Novo Nordisk BioTech, Inc.
    Inventors: Susan L. Elrod, Joel R. Cherry