Patents by Inventor Susan Mary Daluge

Susan Mary Daluge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1R, cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents
    Patent number: 7115590
    Abstract: The present invention relates to phosphoramidate, and phosphate esters of (1R,cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopentene-1nethanol, processes for their preparation, and their use in treating viral infections.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: October 3, 2006
    Assignee: University College Cardiff Consultants Limited
    Inventors: Susan Mary Daluge, Christopher McGuigan
  • Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-YI)phenyl derivatives, their preparation and their use in the treatment of inflammatory conditions and immune disorders
    Patent number: 7002012
    Abstract: A method for the prophylaxis of an inflammatory condition or immune disorder associated with infiltration of leukocytes into inflamed tissue in a subject in need thereof, which method comprises administering to the subject a therapeutically effective amount of a compound of formula (I) or a solvate thereof wherein: X is —O— or —NH—; Q is (—CH2—)p, (—CH?CH—)p, (—C?C—)p where p is an integer of from 0 to 4; R1 is hydrogen or methyl; R2 and R3 independently represent O or S; n is an integer of 1 to 50; and R is hydrogen or methyl.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: February 21, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Gerald Wolberg, Douglas Alan Livingston
  • Chloropyrimidine intermediates
    Patent number: 6870053
    Abstract: The present invention relates to certain novel pyrimidine intermediates and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: March 22, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michelle Joanne Fugett, Michael Tolar Martin
  • Methods of treating periodontal disease
    Patent number: 6770267
    Abstract: The present invention relates to methods of treating periodontal disease.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: August 3, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Cynthia Holder Jurgensen, Michael Tolar Martin, Martin Howard Osterhout
  • Methods of treating periodontal disease
    Publication number: 20040034020
    Abstract: The present invention relates to methods of treating periodontal disease.
    Type: Application
    Filed: February 3, 2003
    Publication date: February 19, 2004
    Inventors: Susan Mary Daluge, Cynthia Holder Jurgensen, Michael Tolar Martin, Martin Howard Osterhout
  • Therapeutic nucleoside compound
    Patent number: 6630477
    Abstract: The present invention relates to (1R,4S)-4-(6-amino-9H-purin-9-yl)-2-cyclopentene-1-methanol and its use in medical therapy for the treatment of hepatitis B infection.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: October 7, 2003
    Assignee: SmithKline Beecham Corporation
    Inventor: Susan Mary Daluge
  • Chloropvrimidine intermediates
    Publication number: 20030187263
    Abstract: The present invention relates to certain novel pyrimidine intermediates and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy.
    Type: Application
    Filed: March 18, 2003
    Publication date: October 2, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michelle Joanne Fugett, Michael Tolar Martin
  • Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-YI)phenyl derivatives, their preparation and their use in the treatment of inflammatory conditions and immune disorders
    Publication number: 20030181471
    Abstract: 1.
    Type: Application
    Filed: June 17, 2002
    Publication date: September 25, 2003
    Inventors: Susan Mary Daluge, Gerald Wolberg, Douglas Alan Livingston
  • Phenyl xanthine derivatives
    Patent number: 6608069
    Abstract: The present invention relates to novel compounds of formula (I): wherein Z represents a 5 or 6 membered cycloalkyl, aryl, substituted cycloalkyl, or substituted aryl, said cycloalkyl, aryl, substituted cycloalkyl or substituted aryl optionally containing one or more heteroatoms selected from 0, N or S; k represents 0 or 1; n represents an integer of 1 to 50; X represents —O—, —N(H)—, —N(C1-6alkyl)-, —N(C3-8cycloalkyl)-, —N(C1-8alkyl)(C3-8 cycloalkyl), —N[(CH2CH2O)m(C1-12 alkyl, aryl, or aralkyl)]-, —CH2O—, —CH2NH—, —CH2N(C1-6alkyl)-, —CH2N(C3-8cycloalkyl)-, or —C1-12alkyl-; Q represents (—CH2)p, (—CH═CH—)p, (—C≡C—)p, (—(O)p1CH2—)p or (—CH2(O)p1)p R6 and R7 independently represent O or S; and all other variables are as defined herein; processes for their preparation, pharmaceutical formulations containing them, and their use in me
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: August 19, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michael Tolar Martin, Martin Howard Osterhout
  • Chloropyrimidine intermediates
    Patent number: 6555687
    Abstract: The present invention relates to certain novel pyrimidine intermediates and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: April 29, 2003
    Inventors: Susan Mary Daluge, Michael Tolar Martin
  • Chloropyrimidine intermediates
    Patent number: 6552193
    Abstract: The present invention is directed to a compound of formula (III) useful in the preparation of 9-substituted 2-aminopurines.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: April 22, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michelle Joanne Fugett, Michael Tolar Martin
  • (1r,cis)-4-(4-amino-7h-pyrrolo'2,3-i(d) pyrimidine-7-yl)-2-cyclopentene-1-methanol derivatives as antiviral
    Publication number: 20030045508
    Abstract: The present invention relates to (1R, cis)-4-(4-Amino-7H-pyrrolo[2,3-(d)]pyrimidine-7-yl)-2-cyclopentene-1-methanol derivatives for the treatment of viral infections.
    Type: Application
    Filed: June 10, 2002
    Publication date: March 6, 2003
    Inventors: Susan Mary Daluge, Kristjan Gudmundsson
  • Analogs of (1s,cis)-4-(2-amino-9h-purin -9-yl) -2-Cyclopentene-1-methanol as antiviral
    Publication number: 20030040506
    Abstract: The present invention relates to analogs of (1S, cis)-4-(2-amino-9H-purin-9-yl)-2-cyclopentene-1-methanol for use in treating viral infections.
    Type: Application
    Filed: June 10, 2002
    Publication date: February 27, 2003
    Inventor: Susan Mary Daluge
  • Methods of treating periodontal disease
    Publication number: 20030032804
    Abstract: The present invention relates to novel compounds of formula (I): processes for their preparation, pharmaceutical formulations containing them, and their use in medicine, particularly in the prophylaxis and treatment of inflammatory conditions, immune disorders, septic shock circulatory disorders, and gastrointestinal inflammation and disorders.
    Type: Application
    Filed: March 26, 2002
    Publication date: February 13, 2003
    Inventors: Susan Mary Daluge, Cynthia Holder Jurgensen, Michael Tolar Martin, Martin Howard Osterhout
  • Chloropvrimidine intermediates
    Publication number: 20020173649
    Abstract: The present invention relates to certain novel pyrimidine intermediates and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy.
    Type: Application
    Filed: June 27, 2002
    Publication date: November 21, 2002
    Inventors: Susan Mary Daluge, Michelle Joanne Fugett, Michael Tolar Martin
  • Benzimidazole derivatives
    Patent number: 6455507
    Abstract: Benzimidazole derivatives useful for treating or preventing viral infections such as those caused by herpes viruses or in the treatment of restenosis following surgical techniques. Methods of preparing these benzimidazole derivatives and pharmaceutical compositions containing them are described.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: September 24, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: John Charles Drach, Leroy B. Townsend, Frank Leslie Boyd, Jr., Stanley Dawes Chamberlain, Susan Mary Daluge, David Norman Deaton, Marc W. Andersen, George Andrew Freeman
  • Chloropyrimidine intermediates
    Patent number: 6448403
    Abstract: A compound of formula (VI) A process for the preparation of a compound of formula (VI): comprising: reacting a compound of formula (III): with an amine of formula R3NH2.
    Type: Grant
    Filed: July 31, 1996
    Date of Patent: September 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Michael Tolar Martin
  • Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-yl) phenyl derivatives, their preparation and their use in the treatment of inflammatory conditions and immune disorders
    Patent number: 6437124
    Abstract: The present invention provides a compound of formula (I) or a solvate thereof wherein: X is —O— or —NH—; Q is (—CH2—)p, (—CH═CH—)p, (—C≡C—)p where p is an integer of from 0 to 4; R1 is hydrogen or methyl; R2 and R3 independently represent O or S n is an integer of 1 to 50; and R is hydrogen or methyl. The present invention also provides pharmaceutical compositions and methods of treatment using the compounds of formula (I).
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: August 20, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Gerald Wolberg, Douglas Alan Livingston
  • BENZIMIDAZOLE DERIVATIVES
    Publication number: 20020094963
    Abstract: The present invention relates to certain bezimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.
    Type: Application
    Filed: March 17, 2000
    Publication date: July 18, 2002
    Inventors: JOHN CHARLES DRACH, LEROY B. TOWNSEND, FRANK LESLIE BOYD, STANLEY DAWES CHAMBERLAIN, SUSAN MARY DALUGE, DAVID NORMAN DEATON, MARC W. ANDERSEN, GEORGE ANDREW FREEMAN
  • Therapeutic nucleosides
    Patent number: 6392085
    Abstract: The present invention relates to intermediates useful for the preparation of certain compounds, for example, purine carbocyclic nucleosides.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: May 21, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Susan Mary Daluge, Douglas Alan Livingston