Patents by Inventor Susan P. James
Susan P. James has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10626267Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.Type: GrantFiled: November 7, 2018Date of Patent: April 21, 2020Assignee: Colorado State University Research FoundationInventors: Susan P. James, David A. Prawel, Richard L. Koch
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Patent number: 10435523Abstract: The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.Type: GrantFiled: December 22, 2016Date of Patent: October 8, 2019Assignee: COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Susan P. James, Min Zhang, Guy Beauregard, Rachael Kurkowski Oldinski
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Publication number: 20190119485Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.Type: ApplicationFiled: November 7, 2018Publication date: April 25, 2019Applicant: Colorado State University Research FoundationInventors: Susan P. James, David A. Prawel, Richard L. Koch
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Patent number: 10266684Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.Type: GrantFiled: July 2, 2018Date of Patent: April 23, 2019Assignee: Colorado State University Research FoundationInventors: Susan P. James, Hieu Bui
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Patent number: 10265440Abstract: The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.Type: GrantFiled: March 23, 2017Date of Patent: April 23, 2019Assignee: COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Susan P. James, Susan S. Yonemura, Ariane Vartanian
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Patent number: 10167387Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.Type: GrantFiled: September 10, 2014Date of Patent: January 1, 2019Assignee: Colorado State University Research FoundationInventors: Susan P. James, Travis S. Bailey, Ketul C. Popat, David A. Prawel, Jackson T. Lewis, Richard L. Koch
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Publication number: 20180305528Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.Type: ApplicationFiled: July 2, 2018Publication date: October 25, 2018Applicant: Colorado State University Research FoundationInventors: Susan P. James, Hieu Bui
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Patent number: 10071186Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.Type: GrantFiled: March 11, 2013Date of Patent: September 11, 2018Assignee: Colorado State University Research FoundationInventors: Susan P. James, Harold Dean, IV, Lakshmi Prasad Dasi, Marcio H. Forleo, Ketul C. Popat, Nicole R. Lewis, David Alois Prawel
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Publication number: 20170189583Abstract: The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.Type: ApplicationFiled: March 23, 2017Publication date: July 6, 2017Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Susan P. JAMES, Susan S. YONEMURA, Ariane VARTANIAN
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Publication number: 20170101516Abstract: The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.Type: ApplicationFiled: December 22, 2016Publication date: April 13, 2017Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Susan P. JAMES, Min ZHANG, Guy BEAUREGARD, Rachael Kurkowski OLDINSKI
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Patent number: 9567447Abstract: An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation.Type: GrantFiled: August 29, 2013Date of Patent: February 14, 2017Assignee: COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Susan P. James, Min Zhang, Guy Beauregard
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Patent number: 9533077Abstract: The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.Type: GrantFiled: August 29, 2013Date of Patent: January 3, 2017Assignee: Colorado State University Research FoundationInventors: Susan P. James, Min Zhang, Guy Beauregard, Rachael Kurkowski Oldinski
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Publication number: 20160222203Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.Type: ApplicationFiled: September 10, 2014Publication date: August 4, 2016Applicant: Colorado State University Research FoundationInventors: Susan P. James, Travis S. Bailey, Ketul C. Popat, David A. Prawel, Jackson T. Lewis, Richard L. Koch
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Publication number: 20150196688Abstract: Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.Type: ApplicationFiled: March 11, 2013Publication date: July 16, 2015Applicant: Colorado State University Research FoundationInventors: Susan P. James, Harold Dean, IV, Lakshmi Prasad Dasi, Marcio H. Forleo, Ketul C. Popat, Nicole R. Lewis, David Alois Prawel
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Publication number: 20150031800Abstract: The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.Type: ApplicationFiled: October 6, 2014Publication date: January 29, 2015Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Susan P. JAMES, Susan S. YONEMURA, Ariane VARTANIAN
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Publication number: 20140093717Abstract: An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation.Type: ApplicationFiled: August 29, 2013Publication date: April 3, 2014Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Susan P. JAMES, Min ZHANG, Guy BEAUREGARD
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Publication number: 20140094568Abstract: The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.Type: ApplicationFiled: August 29, 2013Publication date: April 3, 2014Applicant: Colorado State University Research FoundationInventors: Susan P. JAMES, Min ZHANG, Guy BEAUREGARD, Rachael Kurkowski OLDINSKI
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Patent number: 8524884Abstract: An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between.Type: GrantFiled: April 21, 2008Date of Patent: September 3, 2013Assignee: Colorado State University Research FoundationInventors: Susan P. James, Min Zhang, Guy Beauregard, Rachael Kurkowski Oldinski
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Patent number: 8524886Abstract: An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation.Type: GrantFiled: February 15, 2010Date of Patent: September 3, 2013Assignee: Colorado State University Research FoundationInventors: Susan P. James, Min Zhang, Guy Beauregard
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Publication number: 20130197160Abstract: A new copolymer synthesized from a glycosaminoglycan (GAG) such as hyaluronan/hyaluronic acid (HA), chondroitin sulfates, derma tan sulfates, keratan sulfates, heparan sulfate, and heparin, and an anhydride functionalized hydrophobic polymer, i.e., any polyolefin which has been ‘functionalized’ (grafted onto the backbone or incorporated into the backbone) with anhydride functional groups, such as maleic anhydride-graft-polyethylene, (or, maleated polyethylene), maleic anhydride-graft-polystyrene, maleic anhydride-graft-polypropylene, etc. The functionalized polyolefin may be a polyolefin backbone to which the anhydride functional groups have been grafted, or otherwise incorporated with the backbone. Also, a unique synthesis technique combines a modified GAG with a graft polyolefin, resulting in a unique copolymer with its constituents by-and-large covalently bound to each other.Type: ApplicationFiled: April 18, 2008Publication date: August 1, 2013Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (CSURF)Inventors: Susan P. James, Rachael Kurkowski Oldinski