Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Abstract: Apparatus and methods provide compliance management tools such as for respiratory pressure therapy. In some versions, a respiratory pressure therapy system may include one or more processors, such as of a data server, configured to communicate with a computing device and/or a respiratory pressure therapy device. The respiratory pressure therapy device may be configured to deliver respiratory pressure therapy to a patient for a session. The computing device may be associated with the patient. The processor(s) may be further configured to compute a therapy quality indicator of the session from usage data relating to the session. The therapy quality indicator may be a number derived from contributions of a plurality of usage variables for the session in the usage data. The processor(s) may be further configured to present, such as by transmitting, the therapy quality indicator to the computing device. The therapy quality indicator may promote patient compliance.

Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The invention provides a neck-worn sensor (referred to herein as the ‘necklace’) that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure. And from pulse pressure and pulse transit time, a second algorithm, also employing a linear algorithm, can estimate systolic blood pressure and diastolic blood pressure. Thus, the necklace can measure all five vital signs along with hemodynamic parameters. It also includes a motion-detecting accelerometer, from which it can determine motion-related parameters such as posture, degree of motion, activity level, respiratory-induced heaving of the chest, and falls.

Abstract: The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Abstract: The disclosure relates to isolated microorganisms—including novel strains of the microorganisms—microbial consortia, and agricultural compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial consortia, and agricultural compositions comprising the same, in methods for imparting beneficial properties to target plant species. In particular aspects, the disclosure provides methods of increasing desirable plant traits in agronomically important crop species.

Abstract: Provided herein are compositions and methods for treating, preventing, and reversing malnutrition. In particular, provided herein are compositions and methods for facilitating cognitive repair and preventing obesity (e.g. in children).

Abstract: Provided herein are compositions and methods for treating, preventing, and reversing malnutrition. In particular, provided herein are compositions and methods for facilitating cognitive repair and preventing obesity (e.g. in children).

Abstract: According to some embodiments, a centralized registry data store may contain electronic records that represent movement plan contracts for Unmanned Vehicles (“UVs”). A centralized registry platform may receive information about a potential movement plan contract for a UV and dynamically create a potential multi-dimensional, time-indexed volume representing the potential movement plan contract. The centralized registry platform may then automatically compare the potential multi-dimensional, time-indexed volume with another volume representing another movement plan contract that was previously registered with the centralized registry platform. Based on a result of the comparison, the centralized registry platform may dynamically register the potential movement plan contract in the centralized registry data store.

Abstract: Provided herein are compositions and methods for treating, preventing, and reversing malnutrition. In particular, provided herein are compositions and methods for facilitating cognitive repair and preventing obesity (e.g. in children).

Abstract: The present disclosure features novel methods and systems of using a computer system to facilitate improvement of a weight management intervention. In one embodiment, a method of improving a weight management intervention comprises receiving, by an analysis agent executing on a processor, a daily weight measurement of a patient enrolled in the weight management intervention. A short term period of adherence or non-adherence to the weight management intervention is detected based on the daily weight measurement and at least one previous daily weight measurement. A cause of the short term period of non-adherence is identified. Based on the cause, the weight management intervention can be modified in response. Short-term detection and response to adherence and non-adherence is extremely useful in promoting greater adherence to a weight management intervention, and through greater adherence leading to greater weight loss, lower drop out, greater sustainability of weight loss and greater participant satisfaction.

Abstract: An orange juice beverage composition comprising orange juice and an added multivitamin and mineral component. The orange juice composition of the invention provides a delicious and refreshing way to give the body important vitamins and minerals for good health.

Abstract: A closed fluidic sampling system. The system includes a first port for receiving a sample of fluid and a sampling chamber in fluid communication with the first port. A a one-way valve allows fluid to flow from the first port towards the sampling chamber while preventing backflow of fluid towards the first port. A second port in fluid communication with the sampling chamber enables fluid to be withdrawn from the sampling chamber. The fluid may be a blood component, such as platelets, plasma, whole blood, or red blood cells.

Abstract: A closed fluidic sampling system. The system includes a first port for receiving a sample of fluid and a sampling chamber in fluid communication with the first port. A a one-way valve allows fluid to flow from the first port towards the sampling chamber while preventing backflow of fluid towards the first port. A second port in fluid communication with the sampling chamber enables fluid to be withdrawn from the sampling chamber. The fluid may be a blood component, such as platelets, plasma, whole blood, or red blood cells.