Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Abstract: A user equipment (UE) device may include a processor configured to obtain a configuration specification for at least one discontinuous transmission parameter, wherein the configuration specification includes different values for at least two different Quality of Service (QoS) classes. The processor may be further configured to detect uplink data that is to be sent by the UE device to a device via a base station; determine a QoS class associated with the uplink data; select a value for the at least one discontinuous transmission parameter based on the configuration specification and the determined QoS class associated with the uplink data; and send the uplink data to the base station based on the selected value for the at least one discontinuous transmission parameter.

Abstract: A method of forming a heat-treated liquid nutritional composition having a neutral pH and comprising a water-insoluble plant flavonoid comprises providing an aqueous liquid nutritional composition having a pH of from about 6 to about 7.5 and comprising protein, fat, carbohydrate, and water-insoluble plant flavonoid, homogenizing the liquid nutritional composition at a pressure of at least about 2000 psi, and heat treating the liquid nutritional composition. A heat-treated liquid nutritional composition having a pH of from about 6 to about 7.5 comprises a water-insoluble plant flavonoid, protein, fat and carbohydrate. At least about 75 wt % of the water-insoluble plant flavonoid remains suspended throughout the liquid nutritional composition after two months of storage at room temperature.

Abstract: A base station may include a processor configured to configure a default time period for periodic service requests for discontinuous reception (DRX) for user equipment (UE) devices serviced by the base station. The processor may be further configured to obtain a signal quality value for a UE device serviced by the base station; determine that the obtained signal quality value is less than a low signal quality threshold; and configure a longer time period for the periodic service requests for DRX for the UE device, in response to determining that the obtained signal quality value is less than the low signal quality threshold.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing project tasks using content items. A user can create tasks within a content item. The tasks can be assigned to users and/or be assigned due dates. The content item can be shared with other users such that updates to the content item (e.g., updates to the tasks) can cause sending notifications to users associated with the content item. When a task in the content item is updated, all members of the project can be notified of the updated status of the task. A task list for a project can be created that aggregates tasks from multiple content items associated with the project. Tasks can be organized in the task list according to the content item the task was created in. Updates to tasks in the task list can cause corresponding updates to the tasks in the content items.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing project tasks using content items. A user can create tasks within a content item. The tasks can be assigned to users and/or be assigned due dates. The content item can be shared with other users such that updates to the content item (e.g., updates to the tasks) can cause sending notifications to users associated with the content item. When a task in the content item is updated, all members of the project can be notified of the updated status of the task. A task list for a project can be created that aggregates tasks from multiple content items associated with the project. Tasks can be organized in the task list according to the content item the task was created in. Updates to tasks in the task list can cause corresponding updates to the tasks in the content items.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing project tasks using content items. A user can create tasks within a content item. The tasks can be assigned to users and/or be assigned due dates. The content item can be shared with other users such that updates to the content item (e.g., updates to the tasks) can cause sending notifications to users associated with the content item. When a task in the content item is updated, all members of the project can be notified of the updated status of the task. A task list for a project can be created that aggregates tasks from multiple content items associated with the project. Tasks can be organized in the task list according to the content item the task was created in. Updates to tasks in the task list can cause corresponding updates to the tasks in the content items.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing project tasks using content items. A user can create tasks within a content item. The tasks can be assigned to users and/or be assigned due dates. The content item can be shared with other users such that updates to the content item (e.g., updates to the tasks) can cause sending notifications to users associated with the content item. When a task in the content item is updated, all members of the project can be notified of the updated status of the task. A task list for a project can be created that aggregates tasks from multiple content items associated with the project. Tasks can be organized in the task list according to the content item the task was created in. Updates to tasks in the task list can cause corresponding updates to the tasks in the content items.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing project tasks using content items. A user can create tasks within a content item. The tasks can be assigned to users and/or be assigned due dates. The content item can be shared with other users such that updates to the content item (e.g., updates to the tasks) can cause sending notifications to users associated with the content item. When a task in the content item is updated, all members of the project can be notified of the updated status of the task. A task list for a project can be created that aggregates tasks from multiple content items associated with the project. Tasks can be organized in the task list according to the content item the task was created in. Updates to tasks in the task list can cause corresponding updates to the tasks in the content items.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for managing projects using references between the project and project items. Project items can be, for example, synchronized content items, collaborative content items, other projects, folders, tasks, user accounts, etc. The content management system can create a project identifier for managing data and/or people associated with a project. In various implementations, the content management system can store references between the project and project items in one or more folders associated with the project, in a database, in content item metadata, etc. In some implementations, the storage location of a content item does not affect whether it is associated with the project. When a project is selected by a user, the content management system can generate project view that presents various project items associated with the project in a convenient and easy to access graphical user interface.