Patents by Inventor Susanne M. Steccerda

Susanne M. Steccerda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MUTATIONS ASSOCIATED WITH RESISTANCE TO INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK)
    Publication number: 20150184249
    Abstract: Described herein are mutations that confer resistance to treatment with a BTK inhibitor. Described herein are modified BTK polypeptides that exhibit decreased inhibition (i.e. are resistant) to a covalent and/or irreversible BTK inhibitor. Also described herein modifications of PLCy2 and CARD 11 polypeptides that confer resistance to treatment with a BTK inhibitor. Described herein are diagnostic methods for detecting the modified polypeptides and nucleic acids encoding the modified polypeptides and applications of the methods thereof. Described herein are compositions, combinations, and kits containing the modified polypeptides and methods of using the modified polypeptides. Also described herein are methods of using modified BTK polypeptides as screening agents for the identification and design of second-generation BTK inhibitors.
    Type: Application
    Filed: July 23, 2013
    Publication date: July 2, 2015
    Applicant: PHARMACYCLICS, INC.
    Inventors: Betty Chang, Joseph J. Buggy, Susanne M. Steccerda