Abstract: The present invention provides a method for the treatment of heart failure through the use of small peptide complexes and recombinant proteins which function to enhance contractility in failing hearts and reduce blood pressure in individuals with hypertension by inhibiting the interaction between phospholamban and sacroplasmic reticulum Ca2+ ATPase (SERCA2a) within cardiomyocytes. In addition, a means is provided for the transport of such therapeutic agents into the cytoplasm and nucleus of cardiomyocytes.

Abstract: The present invention provides a method for the treatment of heart failure through the use of small peptide complexes and recombinant proteins which function to enhance contractility in failing hearts and reduce blood pressure in individuals with hypertension by inhibiting the interaction between phospholamban and sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) within cardiomyocytes. In addition, a means is provided for the transport of such therapeutic agents into the cytoplasm and nucleus of cardiomyocytes.

Abstract: A water-dispersible sheet and a cigarette using the sheet are disclosed. The sheet comprises a water-resolvable base paper made from fibrous raw materials and a water-dispersible coating layer containing water-soluble polymer and an alkaline compound. The sheet is also produced through an impregnation treatment for a water-resolvable base paper with a coating mixture containing water-soluble polymer and an alkaline compound, wherein said water-resolvable base paper is made from a mixture of water-dispersible fibers and fibrous carboxymethyl cellulose acid or fibrous carboxyethyl cellulose acid. The gas-permeability of the water-dispersible sheet is controlled by the water-dispersible coating layer or the impregnation treatment.

Abstract: A water-dispersible sheet for cigarettes and a cigarette using the sheet are described. The sheet comprises a water-resolvable base paper and a water-dispersible coating layer containing water-soluble polymer formed on the surface of the base paper, whereby the sheet is adjusted to have an air-permeability of not more than 200 coresta measured with a paper permeability meter, or to have an air-resistance within the range of 0 to 50000 second/100 ml measured with an Oken type air-resistance tester. The water-resolvable base paper is made from fibrous raw materials containing not less than 20% by weight of water-dispersible fibers having fiber dimensions of a l/D value of 0.45 or lower and a L/D value of 60 or lower and a water-retention value of 95% or lower. The sheet is suitable for use as filter joining paper or filter plug wrap for cigarettes.