Abstract: An objection is to provide a method for characterizing a molecule delivery particle, the method comprising determining a molar concentration thereof. The method for characterizing a molecule delivery particle, the method comprising subjecting a molecule delivery particle comprising a first particle and a second particle to particle separation with optical measurement to determine an increment in refractive index of each of the first particle and the second particle; and determining a molar concentration of each of the first particle and the second particle based on the increment in refractive index, a molecular weight, and a specific refractive index increment of each of the first particle and the second particle.

Abstract: In general, according to one embodiment, an ultrasonic diagnostic apparatus includes an image generating unit configured to generate medical images from a multislice which covers an area including the heart of an object. Each slice is almost perpendicular to the long axis of the heart. Each medical image is a short-axis image of the heart. A series of medical images captured at different times correspond to each slice. The embodiment generates a polar map associated with myocardial motion indices from a plurality of medical images. A polar map is segmented into segments. The embodiment calculates the average value of motion indices for each segment. The utility of an average value depends on the range covered by each segment. This embodiment matches the boundary of a segment with the position of a vein. This prevents a deterioration in the utility of average values due to the influences of veins.

Abstract: A control unit (41) included in an image classification apparatus of the present invention performs a step of clustering a plurality of training images for each of a plurality of combination patterns of a plurality of feature quantities that an image has, and a step of selecting, from among the plurality of combination patterns, a classification-use combination pattern to be used in image classification, based on a result of the clustering. The clustering is performed based on degrees of similarity between the training images that have been calculated with use of the feature quantities constituting the combination patterns.

Abstract: It is intended to provide a monoclonal antibody having a growth inhibitory activity against a cell having a human CD20 antigen which is produced by using, as immunogens, a human B cell line expressing the human CD20 antigen and a cell line originating in a non-human animal, which is different from an animal to be immunized and has been transformed with human CD20 DNA, and a monoclonal antibody obtained by chimerization or humanization of the above-described monoclonal antibody. These monoclonal antibodies show biological activities suitable for using as drugs.

Abstract: In general, according to one embodiment, an ultrasonic diagnostic apparatus includes an image generating unit configured to generate medical images from a multislice which covers an area including the heart of an object. Each slice is almost perpendicular to the long axis of the heart. Each medical image is a short-axis image of the heart. A series of medical images captured at different times correspond to each slice. The embodiment generates a polar map associated with myocardial motion indices from a plurality of medical images. A polar map is segmented into segments. The embodiment calculates the average value of motion indices for each segment. The utility of an average value depends on the range covered by each segment. This embodiment matches the boundary of a segment with the position of a vein. This prevents a deterioration in the utility of average values due to the influences of veins.

Abstract: A control unit (41) included in an image classification apparatus of the present invention performs a step of clustering a plurality of training images for each of a plurality of combination patterns of a plurality of feature quantities that an image has, and a step of selecting, from among the plurality of combination patterns, a classification-use combination pattern to be used in image classification, based on a result of the clustering. The clustering is performed based on degrees of similarity between the training images that have been calculated with use of the feature quantities constituting the combination patterns.

Abstract: Disclosed are a method for determining the affinity of an antibody capable of binding to a cell membrane surface antigen for the antigen; and a method for assaying or screening an antibody capable of binding to a cell membrane surface antigen by utilizing the determination method. In the determination of the affinity of the antibody for the antigen, floating cells presenting the antigen on the surface of the cell membrane thereof are used and the B/F separation of the cells is made by centrifugation or on a filter through which the cells cannot pass.

Abstract: A method for monitoring cells is provided capable of determining the stage in cell cycle of a cell in a rapid and highly reliable manner. A step of obtaining an image that reflects the chromosomal state in the cell, and a step of calculating a parameter that corresponds to the chromosomal state based on the image to determine the stage in the cell cycle on the basis of the calculation result are included.

Abstract: The present invention provides a humanized anti human CD20 monoclonal antibody, selection criteria therefor, humanized antibodies selected using that criteria and showing biological characteristics suitable for use as pharmaceuticals.

Abstract: A vertical mill, a classifier for the mill, and a controller for the classifier. The vertical mill includes a casing having a top plate, and the classifier is adjacent the top plate. Beneath the top plate, upon which impinges an upwardly moving gas and powdery material being supplied from the lower portion of the casing, are provided a plurality of rotary blades or rotary rods which have a vertical axis of rotation. A gap is provided between the rotary blades and the top plate, and an annular impingement member is suspended from the top of the casing to outwardly surround the plurality of rotary blades in such a way as to shield the gap. Further, an opening is provided adjacent the impingement member through which a portion of the gas and powdery material pass. The controller of the classifier includes means for adjusting the opening through which the powdery material passes.

Abstract: A roller mill according to this invention includes a base and a table supported on the base, the table being adapted to be rotated on a generally vertical axis. The table has an annular groove formed in its top surface, the groove having a semicircular cross section. At least one roller is supported by the base above the table, each roller being rotatable on an axis which intersects with the vertical axis of the table. Each roller has an arcuate peripheral portion which forms part of a circle of curvature in cross section. The roller and the table rotate on their respective axes, and they are adapted to compress and mill material in the groove betweem them, a clearance which receives the material being formed between the peripheral portion of the roller and the groove.

Abstract: A roller mill according to this invention includes a table adapted to be rotatably driven on a substantially vertical axis. The table is adapted to receive the material to be milled in a central area around the axis. The table has a substantially horizontal upper surface, and an annular groove is formed in the upper surface radially outwardly from the central area. The groove has a curved bottom surface. A least one roller is provided having an axis of rotation which is above the upper surface of the table and substantially intersects the table axis. The roller extends into and rolls in the groove and has an outer peripheral surface which is curved in cross section. The mill when in use has the table and the roller rotated, and the material extends into a clearance space formed between the peripheral surface of the roller and the bottom surface of the groove.

Abstract: In a transmitter section of ultrasonic imaging apparatus, a digital delay circuit is provided. The digital delay circuit includes a clock pulse selector for selecting one phase-shifted clock signal from the plurality of phase-shifted reference signal trains based upon delay time information of the control data signals of the timing control device, a clock counter for counting a pulse number of one phase-shifted clock signal derived from the clock pulse selector based upon the delay time information of the control data signals, thereby obtaining a digitally-delayed phase-shifted clock signal, and a wave number counter for counting a wave number of said digitally-delayed clock signal derived from said clock counter based upon wave number information of the control data signal, thereby finally obtaining a digitally-delayed phase-shifted signal having the desired wave number for the exciting phase.