Abstract: Methods of treating autoimmune diseases, such as systemic lupus erythematosus using domain antibodies that specifically bind human CD28 are provided. The methods may comprise at least one administration cycle comprising one dose of the domain antibody. The method reduces symptoms of systemic lupus erythematosus compared to placebo.

Abstract: A method, system, and computer program product are provided for managing email disk usage based on user specified conditions. An incoming email for a user is scanned for email expressions. A determination is made as to whether one of the email expressions matches one of a number of listed expressions forming a matched expression. Responsive to a presence of a matched expression, a determination is made as to whether a first threshold associated with the matched expression is met or exceeded. Responsive to the first threshold being met or exceeded, a notification is sent to the user of the first threshold being met.

Abstract: A method, system, and computer program product are provided for managing email disk usage based on user specified conditions. An incoming email for a user is scanned for email expressions. A determination is made as to whether one of the email expressions matches one of a number of listed expressions forming a matched expression. Responsive to a presence of a matched expression, a determination is made as to whether a first threshold associated with the matched expression is met or exceeded. Responsive to the first threshold being met or exceeded, a notification is sent to the user of the first threshold being met.

Abstract: Mechanisms are provided for managing email disk usage based on user specified conditions. An incoming email for a user is scanned for email expressions. A determination is made as to whether one of the email expressions matches one of a number of listed expressions forming a matched expression. Responsive to a presence of a matched expression, a determination is made as to whether a first threshold associated with the matched expression is met or exceeded. Responsive to the first threshold being met or exceeded, a notification is sent to the user of the first threshold being met.

Abstract: A computer implemented method, apparatus, and computer usable program product for utilizing instruction trace registers. In one embodiment, a value in a target processor register in a plurality of processor registers is updated in response to executing an instruction associated with program code. In response to updating the value in the target processor register, an address for the instruction is copied from an instruction address register into an instruction trace register associated with the target processor register. The instruction trace register holds the address of the instruction that updated the value stored in the target processor register.

Abstract: A method facilitates instant message (IM) session transfer of messages intended for an IM user to a new IM session being established by the user. Existing IM sessions may be queried for active IM sessions when the user is connecting to an instant message service. If there is an active session for the user, the IM server will request the content and sender of active messages waiting for the user, and transfer this information to the new IM session being established for the user. In this way, the user does not “miss” IM message(s) intended for him or her while going between existing, active IM sessions and new IM sessions. As used herein, session or sessions refer to IM session or IM sessions.

Abstract: A computer implemented method, apparatus, and computer usable program product for utilizing instruction trace registers. In one embodiment, a value in a target processor register in a plurality of processor registers is updated in response to executing an instruction associated with program code. In response to updating the value in the target processor register, an address for the instruction is copied from an instruction address register into an instruction trace register associated with the target processor register. The instruction trace register holds the address of the instruction that updated the value stored in the target processor register.

Abstract: A method, system, and computer program product are provided for managing email disk usage based on user specified conditions. An incoming email for a user is scanned for email expressions. A determination is made as to whether one of the email expressions matches one of a number of listed expressions forming a matched expression. Responsive to a presence of a matched expression, a determination is made as to whether a first threshold associated with the matched expression is met or exceeded. Responsive to the first threshold being met or exceeded, a notification is sent to the user of the first threshold being met.

Abstract: A computer implemented method, apparatus, and computer usable program product for managing e-mail messages. Responsive to receiving an e-mail message for a recipient, a determination is made as to whether a condition is present in the e-mail message using a policy associated with the recipient. If the condition is present in the e-mail message, a determination is made as to whether a number of other e-mail messages having the condition exceed a threshold associated with condition. An oldest e-mail message is removed from the number of e-mail messages having the condition in response to a determination that the number of e-mail messages exceeds the threshold.