Patents by Inventor Suzanne U. Emerson

Suzanne U. Emerson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human/simian chimeric hepatitis A virus vaccine
    Patent number: 6146643
    Abstract: The present invention relates, in general, to a substantially pure preparation of the simian hepatitis A viral isolate AGM-27; a substantially pure preparation of the genomic DNA of simian hepatitis A viral isolate AGM-27; a pharmaceutical composition comprising the simian hepatitis A viral isolate AGM-27; a method of preventing hepatitis A in an animal; and a vaccine comprising the simian hepatitis A viral isolate AGM-27.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 14, 2000
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Sergei A. Tsarev, Suzanne U. Emerson, Robert H. Purcell
  • Hepatitis A virus vaccines
    Patent number: 6113912
    Abstract: A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 5, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ann W. Funkhouser, Suzanne U. Emerson, Robert H. Purcell, Eric D'Hondt
  • Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
    Patent number: 6054567
    Abstract: The invention relates to the expression of open reading frame 2 (ORF-2) proteins of a strain of hepatitis E virus from Pakistan (SAR-55) in a eukaryotic expression system. The expressed proteins can serve as an antigen in diagnostic immunoassays and/or as an immunogen or vaccine to protect against infection by hepatitis E.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: April 25, 2000
    Assignees: The United States of America as represented by the Department of Health and Human Services, Novavax, Inc.
    Inventors: Suzanne U. Emerson, Robert H. Purcell, Sergei A. Tsarev, Robin A. Robinson
  • Production of complementary DNA representing hepatitis A viral sequences by recombinant DNA methods and uses therefor
    Patent number: 5849562
    Abstract: Methods for producing HAV cDNA, products thereof, and uses thereof, are described. HAV cDNA is produced, for example, by reverse transcribing HAV RNA and subsequently inserting the HAV cDNA into bacterial plasmids by genetic-engineering techniques. Transformed bacteria are then cloned and cultured to produce replicated chimeric plasmids containing the HAV cDNA. Such HAV cDNA is useful in assaying for the presence of HAV and in the production of HAV antigen and in the production of antibodies against HAV.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 15, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert H. Purcell, Suzanne U. Emerson
  • Vaccine against hepatitis a comprising simian HAV isolate AGM-27
    Patent number: 5476658
    Abstract: The present invention relates, in general, to a substantially pure preparation of the simian hepatitis A viral isolate AGM-27; a substantially pure preparation of the genomic DNA of simian hepatitis A viral isolate AGM-27; a pharmaceutical composition comprising the simian hepatitis A viral isolate AGM-27; a method of preventing hepatitis A in an animal; and a vaccine comprising the simian hepatitis A viral isolate AGM-27.
    Type: Grant
    Filed: March 26, 1991
    Date of Patent: December 19, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Sergie A. Tsarev, Suzanne U. Emerson, Michael S. Balayan, Robert H. Purcell
  • Techniques for producing site-directed mutagenesis of cloned DNA
    Patent number: 5284760
    Abstract: A method is described whereby new cDNA or RNA sequences can be introduced into or substituted for cDNA in any chosen position without specific sequence requirements using the polymerase chain reaction (PCR). The method entails the use of primers which are complementary to the 3' and 5' ends of the desired sequence to be inserted as well as to the 3' and 5' ends of the chosen site of insertion in the acceptor molecule. The desired sequence is amplified by PCR such that single stranded fragments are produced. The single stranded fragment of the desired sequence is then annealed to a single stranded acceptor molecule at the site of insertion and extended to produce a double stranded molecule. The double stranded molecule is then separated into two strands which are identical except that one of the strands contains the desired sequence inserted at the chosen site. A second double stranded molecule is then generated.
    Type: Grant
    Filed: September 23, 1991
    Date of Patent: February 8, 1994
    Inventors: Stephen M. Feinstone, Czeslaw Wychowski, Jonathan E. Silver, Suzanne U. Emerson
  • Vaccine against hepatitis A virus
    Patent number: 4894228
    Abstract: The present invention provides an attenuated hepatitis A virus useful as a vaccine.
    Type: Grant
    Filed: July 12, 1988
    Date of Patent: January 16, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert H. Purcell, John R. Ticehurst, Jeffrey I. Cohen, Suzanne U. Emerson, Stephan M. Feinstone, Richard J. Daemer, Ian D. Gust