Patents by Inventor Sven Bocklandt

Sven Bocklandt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of genetically altering and producing allergy free cats
    Patent number: 10626417
    Abstract: A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct. The phenotype of the transgenic cat is transmissible to its offspring.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: April 21, 2020
    Inventors: David B. Avner, James Kehler, Sven Bocklandt
  • METHODS FOR PRODUCING HYPO-ALLERGENIC CATS USING GENE EDITING TECHNOLOGY
    Publication number: 20200008405
    Abstract: A genetically modified cat produced through gene editing with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the genetically modified cat by targeting either the gene sequence of the Fel d I locus or sequences flanking the coding sequence of the two contiguous Fel d I genes with specialized gene editing constructs. The genotype and phenotype of the genetically modified cat is transmissible to its offspring.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 9, 2020
    Inventors: David B. Avner, Sven Bocklandt, James Kehler
  • Method to estimate age of individual based on epigenetic markers in biological sample
    Patent number: 10435743
    Abstract: The invention provides methods and materials that use observation of DNA characteristics to obtain information relating to the age of individuals. The instant disclosure identifies 88 sites in or near 80 genes for which the degree of cytosine methylation in epithelial and/or white blood cells is significantly correlated with age. In illustrative embodiments of the invention, cytosine methylation patterns the promoters of the EDARADD, TOMILI, and NPTX2 genes are used to predict the age of an individual with a high degree of accuracy.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: October 8, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Eric Vilain, Sven Bocklandt, Steve Horvath, Janet Sinsheimer
  • METHOD TO ESTIMATE AGE OF INDIVIDUAL BASED ON EPIGENETIC MARKERS IN BIOLOGICAL SAMPLE
    Publication number: 20140228231
    Abstract: The invention provides methods and materials that use observation of DNA characteristics to obtain information relating to the age of individuals. The instant disclosure identifies 88 sites in or near 80 genes for which the degree of cytosine methylation in epithelial and/or white blood cells is significantly correlated with age. In illustrative embodiments of the invention, cytosine methylation patterns the promoters of the EDARADD, TOMILI, and NPTX2 genes are used to predict the age of an individual with a high degree of accuracy.
    Type: Application
    Filed: May 18, 2012
    Publication date: August 14, 2014
    Applicant: The Regents of the University of California
    Inventors: Eric Vilain, Sven Bocklandt, Steve Horvath, Janet Sinsheimer
  • Method of Genetically Altering and Producing Allergy Free Cats
    Publication number: 20120142110
    Abstract: A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct. The phenotype of the transgenic cat is transmissible to its offspring.
    Type: Application
    Filed: June 24, 2011
    Publication date: June 7, 2012
    Inventors: David B. Avner, Sven Bocklandt, James Kehler
  • Nucleic acid sequences and homologous recombination vectors for distruption of a Fel D I gene
    Patent number: 8119785
    Abstract: A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct. The phenotype of the transgenic cat is transmissible to its offspring.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: February 21, 2012
    Inventors: David B. Avner, Sven Bocklandt, James Kehler
  • Method of genetically altering and producing allergy free cats
    Publication number: 20090298168
    Abstract: A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct. The phenotype of the transgenic cat is transmissible to its offspring.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 3, 2009
    Inventors: David B. Avner, Sven Bocklandt, James Kehler