Patents by Inventor Svetlana Alekseevna Dubiley

Svetlana Alekseevna Dubiley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of continuous/contiguous stacking hybridization as a diagnostic tool
    Patent number: 6440671
    Abstract: A method for detecting disease-associated alleles in patient genetic material is provided whereby a first group of oligonucleotide molecules, synthesized to compliment base sequences of the disease associated alleles is immobilized on a predetermined position on a substrate, and then contacted with patient genetic material to form duplexes. The duplexes are then contacted with a second group of oligonucleotide molecules which are synthesized to extend the predetermined length of the oligonucleotide molecules of the first group, and where each of the oligonucleotide molecules of the second group are tagged and either incorporate universal bases or a mixture of guanine, cytosine, thymine, and adenine, or complementary nucleotide strands that are tagged with a different fluorochrome which radiates light at a predetermined wavelength.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: August 27, 2002
    Assignee: The University of Chicago
    Inventors: Andrei Darievich Mirzabekov, Eugene Vladislavovich Kirillov, Sergei Valeryevich Parinov, Victor Evgenievich Barski, Svetlana Alekseevna Dubiley
  • Use of continuous/contiguous stacking hybridization as a diagnostic tool
    Patent number: 6090549
    Abstract: A method for detecting disease-associated alleles in patient genetic material is provided whereby a first group of oligonucleotide molecules, synthesized to compliment base sequences of the disease associated alleles is immobilized on a predetermined position on a substrate, and then contacted with patient genetic material to form duplexes. The duplexes are then contacted with a second group of oligonucleotide molecules which are synthesized to extend the predetermined length of the oligonucleotide molecules of the first group, and where each of the oligonucleotide molecules of the second group are tagged and either incorporate universal bases or a mixture of guanine, cytosine, thymine, and adenine, or complementary nucleotide strands that are tagged with a different fluorochrome which radiates light at a predetermined wavelength.
    Type: Grant
    Filed: May 13, 1997
    Date of Patent: July 18, 2000
    Assignee: University of Chicago
    Inventors: Andrei Darievich Mirzabekov, Eugene Vladislavovich Kirillov, Sergei Valeryevich Parinov, Victor Evgenievich Barski, Svetlana Alekseevna Dubiley
  • Microchip method for the enrichment of specific DNA sequences
    Patent number: 5851772
    Abstract: A method for enriching specific genetic material sequences is provided, whereby oligonucleotide molecules complementary to the desired genetic material is first used to isolate the genetic material from a first source of genomic material. Then the genetic material is used as a label to isolate similar genetic sequences from other sources.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: December 22, 1998
    Assignee: University of Chicago
    Inventors: Andrei Darievich Mirzabekov, Yuri Petrovich Lysov, Valentine Vladimirovich Shick, Svetlana Alekseevna Dubiley