Abstract: Embodiments of the present invention feature a device (1) and method for performing steps of a multi-step process in parallel. The device (1) and method feature a rotor assembly (13) having vessel stations (33) and stator assembly (15) having work positions. The rotor assembly (13) rotates the vessels (17) to the work stations to perform steps of a multi-step process at the same time.

Abstract: A connector for connecting a first conduit to a second conduit including a body having a passageway therethrough, a first cavity and a second cavity, a first sealing member, a second sealing member, a first compression, a second compression fitting, a first set of one or more keys and one or more mated key ways for preventing rotation of the first conduit when the first sealing member is compressed, and a second set of one or more keys and one or more mated key ways for preventing rotation of the second conduit when the second sealing member is compressed, wherein each of the first cavity and the second cavity in the body is configured to receive one of the sealing members or a detachable holder configured to receive one of the sealing members.

Abstract: An analytical apparatus includes a sample-injection valve, a sample pump, at least two sources of standards, and a selection valve. The sample-injection valve has an output port in fluid communication with a LC column, and an input port in fluid communication with a mobile-phase supply line. The at least two sources of standards are associated with at least two pharmaceutical compounds. The selection valve fluidically and selectably connects the sample pump to the at least two sources of standards, to the sample-injection valve, and to at least two pharmaceutical-manufacturing process lines associated with the at least two pharmaceutical compounds. A method for controlling a pharmaceutical manufacturing process includes switching the selection valve to alternately and repeatedly sample the at least two sources of standards and material flowing through the at least two pharmaceutical-manufacturing process lines.

Abstract: An online sample manager of a liquid chromatography system includes a fluidic tee having a first inlet port, a second inlet port, and an outlet port. A diluent pump moves diluent from a diluent source to the first inlet port of the fluidic tee. A valve has a fluidic intake port connected to a process source for acquiring a process sample therefrom. A pumping system moves the acquired process sample from the valve into the second inlet port of the fluidic tee where the process sample merges with the diluent arriving at the first inlet port to produce a diluted process sample that flows out from the outlet port of the fluidic tee.

Abstract: Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.

Abstract: Described is a rotary valve including a stator element and a rotor element. The stator element defines a first inlet passage, a second inlet passage, and a first outlet passage, respectively, having a first inlet port, second inlet port and first outlet port in a stator face. The rotor element has a rotor face in contact with the stator face and has a first channel and a second channel formed therein. The rotor element is rotatably movable about a rotational axis to at least a first position and a second position. In the first position, the first inlet port is fluidly coupled to the first outlet passage by the first channel and the second inlet port is fluidly coupled to the first outlet passage by the second channel. In the second position, the first inlet port is fluidly coupled to the first outlet passage by the first and second channels.

Abstract: A connector for connecting a first conduit to a second conduit including a body having a passageway therethrough, a first cavity and a second cavity, a first sealing member, a second sealing member, a first compression, a second compression fitting, a first set of one or more keys and one or more mated key ways for preventing rotation of the first conduit when the first sealing member is compressed, and a second set of one or more keys and one or more mated key ways for preventing rotation of the second conduit when the second sealing member is compressed, wherein each of the first cavity and the second cavity in the body is configured to receive one of the sealing members or a detachable holder configured to receive one of the sealing members.

Abstract: The present invention is a capillary interconnection fitting and method of clamping a capillary in the fitting that separates a forward ferrule that holds the capillary from a secondary clamping device. The fitting comprises a sealing ferrule, a compression screw and a clamping device. The ferrule is fitted in a compression screw that mates to a fluidic component. The clamping device is decoupled from the ferrule and coupled to the compression screw.

Abstract: An analytical apparatus includes a sample-injection valve, a sample pump, at least two sources of standards, and a selection valve. The sample-injection valve has an output port in fluid communication with a LC column, and an input port in fluid communication with a mobile-phase supply line. The at least two sources of standards are associated with at least two pharmaceutical compounds. The selection valve fluidically and selectably connects the sample pump to the at least two sources of standards, to the sample-injection valve, and to at least two pharmaceutical-manufacturing process lines associated with the at least two pharmaceutical compounds. A method for controlling a pharmaceutical manufacturing process includes switching the selection valve to alternately and repeatedly sample the at least two sources of standards and material flowing through the at least two pharmaceutical-manufacturing process lines.

Abstract: A method of liquid chromatography includes providing an injection valve, drawing a sample and a diluent while mixing, pushing the mixed sample and diluent onto a sample loop of the injection valve, and injecting the mixed sample and diluent. An analytical apparatus includes a proportioning unit, an injection valve having a sample loop, and a sample pump. The injection valve has a draw state and a load state, and has a port in fluidic communication with an outlet port of the proportioning unit. The sample pump is in fluidic communication with the outlet port of the proportioning unit, if the injection valve is in the draw state, to draw both a sample and a diluent through the proportioning unit and the injection valve, and in fluidic communication with the sample loop, if the injection valve is in the load state, to push the drawn sample and diluent onto the sample loop.

Abstract: Embodiments of the present invention feature a device (1) and method for performing steps of a multi-step process in parallel. The device (1) and method feature a rotor assembly (13) having vessel stations (33) and stator assembly (15) having work positions. The rotor assembly (13) rotates the vessels (17) to the work stations to perform steps of a multi-step process at the same time.

Abstract: A device for connecting a fluid conduit to an orifice of a vessel includes a flexible fitting, a deformable fitting, and one or more compression fittings. The flexible fitting can fix a position of the fluid conduit with respect to the orifice of the vessel, and the deformable fitting can provide a fluid seal between the fluid conduit and the orifice of the vessel. A method for connecting a fluid conduit to an orifice of a vessel includes urging a deformable fitting against both a surface of the fluid conduit and the orifice, urging a flexible fitting toward a surface of the fluid conduit, and attaching the flexible fitting to the orifice.

Abstract: The present invention is a capillary interconnection fitting and method of clamping a capillary in the fitting that separates a forward ferrule that holds the capillary from a secondary clamping device. The fitting comprises a sealing ferrule, a compression screw and a clamping device. The ferrule is fitted in a compression screw that mates to a fluidic component. The clamping device is decoupled from the ferrule and coupled to the compression screw.