Patents by Inventor Sylvia E. Schwarz

Sylvia E. Schwarz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimized DNA sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins
    Patent number: 8530637
    Abstract: Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: September 10, 2013
    Assignee: Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus
    Inventors: Winfried S. Wels, Benjamin Daelken, Sylvia E. Schwarz
  • Optimized DNA Sequence Of An Antibody To Improve Quality And Yield Of Bacterially Expressed Antibody Fusion Proteins
    Publication number: 20110105742
    Abstract: Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
    Type: Application
    Filed: January 6, 2011
    Publication date: May 5, 2011
    Applicant: TopoTarget Germany AG
    Inventors: Winfried S. WELS, Benjamin Daelken, Sylvia E. Schwarz
  • Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins
    Patent number: 7887801
    Abstract: Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: February 15, 2011
    Assignee: Topotarget Germany AG
    Inventors: Winfried S. Wels, Benjamin Daelken, Sylvia E. Schwarz
  • OPTIMIZED DNA AND PROTEIN SEQUENCE OF AN ANTIBODY TO IMPROVE QUALITY AND YIELD OF BACTERIALLY EXPRESSED ANTIBODY FUSION PROTEINS
    Publication number: 20090018079
    Abstract: Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
    Type: Application
    Filed: July 10, 2008
    Publication date: January 15, 2009
    Inventors: Winfried S. WELS, Benjamin Daelken, Sylvia E. Schwarz