Abstract: The present disclosure features, inter alia, compositions and systems for delivery of adhesive compositions to a site in a subject utilizing image guided delivery, as well as related methods.

Abstract: This disclosure relates to oligonucleotides, compositions and methods useful for reducing LDHA expression, particularly in hepatocytes.

Abstract: An embodiment of the disclosure provides a universal sealing apparatus for one or more cannulas. The apparatus includes a first portion, a second portion, and a third portion. The first and second portions are configured to removably adhere directly or indirectly to a nose. The third portion is coupled to the first and second portions. The third portion removably couples to one or more cannulas and places a force upon a base of flared portions of the one or more cannulas when the first and second portions are adhered to the nose. The force maintains a fluid seal of the one or more cannulas within one or more respective nostrils of the nose.

Abstract: Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

Abstract: Containers are provided and include a container body having an opening extending into a hollow interior, and a cap extending across the opening. The cap has an inlet port with an inlet valve configured to couple to a fluid source such that fluid can be delivered through the inlet valve to pressurized the hollow interior of the container body. The cap also has an outlet port with an outlet valve having a cracking pressure at which the outlet valve is configured to move from a closed configuration to an open configuration to dispense fluid from the hollow interior, and a closing pressure at which the outlet valve is configured to move from the open configuration to the closed configuration to prevent fluid from passing therethrough. The cracking pressure is greater than the closing pressure.

Abstract: Containers are provided and include a container body having an opening extending into a hollow interior, and a cap extending across the opening. The cap has an inlet port with an inlet valve configured to couple to a fluid source such that fluid can be delivered through the inlet valve to pressurized the hollow interior of the container body. The cap also has an outlet port with an outlet valve having a cracking pressure at which the outlet valve is configured to move from a closed configuration to an open configuration to dispense fluid from the hollow interior, and a closing pressure at which the outlet valve is configured to move from the open configuration to the closed configuration to prevent fluid from passing therethrough. The cracking pressure is greater than the closing pressure.

Abstract: A cooking system positionable on a support surface includes a housing having a hollow chamber including an internal cooking chamber for receiving a food item, at least one radiative heating element arranged within the hollow interior and operable to heat said cooking chamber and a convection heater disposed within the hollow chamber and operable to heat the cooking chamber. The cooking system is operable in a convection cooking mode and during the convection cooking mode, the at least one radiative heating element is selectively energized.

Abstract: The present invention provides methods for the treatment of non-alcoholic steatohepatitis (NASH) including advanced fibrotic and/or cirrhotic stages of NASH. The methods include administration of a compound comprising a double stranded RNAi (dsRNAi) oligonucleotide, or a pharmaceutically acceptable salt thereof, to the patient. The dsRNAi oligonucleotide optionally contains an antisense strand and a sense strand, wherein the antisense strand and the sense strand form a duplex region, and wherein the antisense strand comprises a region of complementarity to a KHK mRNA target sequence.

Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: A method is disclosed for producing photocatalytic coated ceramic granules. The method involves providing a coatable composition containing an inorganic binder and a variety of photocatalytic particles, such as TiO2, ZnO, Ti(OH)4, doped derivatives, or combinations thereof. These photocatalytic particles have a surface area per weight of no more than 15 m2/g. The coatable composition is then applied to uncoated base ceramic granules, resulting in intermediate coated granules. Finally, the intermediate coated granules are heated at a temperature of at least 700° C., leading to the formation of photocatalytic coated ceramic granules. These granules exhibit a Total Solar Reflectance (TSR) value of at least 0.7. This method offers an efficient and effective way to produce ceramic granules with enhanced photocatalytic properties.

Abstract: Table top sanitizer dispenser bottle bases are disclosed herein. An exemplary table top sanitizer dispenser bottle base includes a movable upper housing, the upper moveable housing has a floor with an aperture located therein and a peripheral wall. The top sanitizer dispenser bottle includes a lower stationary housing. The upper movable housing is connected to the lower stationary housing and is configured to move linearly upward and downward with respect to lower stationary. One or more biasing members bias the upper movable housing upward. A switch is included and the upper movable housing has an engagement member or surface for actuating the switch upon downward movement of the upper movable housing. At least one of a visual indicator and an audible indicator are also included. Control circuitry is provided for activating the one or more of a visual indicator and audible indicator when the engagement member actuates the switch.

Abstract: Secure circuitry detects a latency between when an interrupt occurred and when the interrupt was released in correspondence with handling of the interrupt. The secure circuitry detects an interval between consecutive occurrences of the interrupt. In response to either or both of the latency exceeding a latency limit and the interval exceeding an interval limit, the secure circuitry performs an action.

Abstract: An electrosurgical instrument includes a pair of jaws, an endoscope configured to capture image data of a surgical site including the electrosurgical instrument, and an energy generator coupled to the electrosurgical instrument. The energy generator is configured to generate an energy output to the electrosurgical instrument. The system also includes an endoscope controller which includes a processor and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the energy-based surgical system to access the captured image, determine a thickness of tissue grasped by the pair of jaws based on the image, and control the energy output of the energy generator based on the determined thickness.

Abstract: A building structure comprising a first film and a second film. The first film and the second film are each impregnated with L-Dopa. The building structure further includes regolith bulk material between the first film and the second film.

Abstract: Various implementations disclosed herein include devices, systems, and methods that provide video content (e.g., a TV show, a recorded sporting event, a movie, a 3D video, etc.) within a 3D environment using parameters selected based on one or more contextual factors. Such contextual factors may be determined based on an attribute of the content (e.g., its intended purpose or viewing environment), the user (e.g., the user's visual quality, interpupillary distance, etc.), the 3D environment (e.g., current lighting conditions, spatial considerations, etc.), or other context attributes.

Abstract: An impaction handle for use during a surgical procedure to implant a fixed-bearing tibial tray into a surgically-prepared proximal end of a tibia is disclosed. The impaction handle includes an impact plate defining a proximal end of the impaction handle and an impact head defining a distal end of the impaction handle. The impaction handle also has an elongated shaft extending between the impact plate and the impact head, along with a locking mechanism to lock the handle to the tibial tray. The locking mechanism includes a thumbwheel positioned in the impact head and a locking shaft secured to the thumbwheel.

Abstract: A system for provisioning credentials onto an electronic device is provided. The system may include a payment network subsystem, a service provider subsystem, a primary user device, and a secondary user device. The user may select a particular payment card to provision onto the secondary user device by providing an input at the primary user device. A broker module running on the service provider subsystem may then transfer a disabled pass to the secondary user device. Concurrently, the payment network subsystem may direct a trusted service manager module on the service provider subsystem to write credential information onto a secure element within the secondary user device. Once the secure element has been updated, the broker module may provide an activated pass to the secondary user device so that the secondary user device can be used to perform NFC-based financial transactions at a merchant terminal.

Abstract: This invention relates to compounds, compositions, and methods useful for reducing ?-1 antitrypsin target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.