Patents by Inventor Taco Willem Kuijpers

Taco Willem Kuijpers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor H potentiating antibodies and uses thereof
    Patent number: 11820814
    Abstract: Provided herein are novel isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H, or nucleic acids or vectors encoding such antibodies and fragments. Further provided herein is the use of such antibodies, fragments, nucleic acids or vectors for inhibiting complement activation and treatment of disorders associated with complement activation.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: November 21, 2023
    Assignees: GEMINI THERAPEUTICS SUB, INC., STICHTING SANQUIN BLOEDVOORZIENING
    Inventors: Scott Lauder, Tom Purcell, Sridhar Govindarajan, Taco Willem Kuijpers, Diana Wouters, Maria Clara Brouwer, Richard Benjamin Pouw, Taede Rispens, Ilse Jongerius, Gillian Dekkers
  • FACTOR H POTENTIATING ANTIBODIES AND USES THEREOF
    Publication number: 20220372120
    Abstract: Provided herein are novel isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H, or nucleic acids or vectors encoding such antibodies and fragments. Further provided herein is the use of such antibodies, fragments, nucleic acids or vectors for inhibiting complement activation and treatment of disorders associated with complement activation.
    Type: Application
    Filed: July 17, 2020
    Publication date: November 24, 2022
    Inventors: Scott LAUDER, Tom PURCELL, Sridhar GOVINDARAJAN, Taco Willem KUIJPERS, Diana WOUTERS, Maria Clara BROUWER, Richard Benjamin POUW, Taede RISPENS, Ilse JONGERIUS, Gillian DEKKERS
  • FACTOR H POTENTIATING ANTIBODIES AND USES THEREOF
    Publication number: 20220356235
    Abstract: The invention relates to novel isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H. The invention further relates to the use of such antibodies and fragments for inhibiting complement activation and treatment of disorders associated with complement activation.
    Type: Application
    Filed: June 1, 2022
    Publication date: November 10, 2022
    Inventors: Taco Willem KUIJPERS, Diana WOUTERS, Maria Clara BROUWER, Richard Benjamin POUW
  • Factor H potentiating antibodies and uses thereof
    Patent number: 11377487
    Abstract: The invention relates to novel isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H. The invention further relates to the use of such antibodies and fragments for inhibiting complement activation and treatment of disorders associated with complement activation.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: July 5, 2022
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Taco Willem Kuijpers, Diana Wouters, Maria Clara Brouwer, Richard Benjamin Pouw
  • FACTOR H POTENTIATING ANTIBODIES AND USES THEREOF
    Publication number: 20210054059
    Abstract: The invention relates to novel isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H. The invention further relates to the use of such antibodies and fragments for inhibiting complement activation and treatment of disorders associated with complement activation.
    Type: Application
    Filed: January 15, 2019
    Publication date: February 25, 2021
    Inventors: Taco Willem KUIJPERS, Diana WOUTERS, Maria Clara BROUWER, Richard Benjamin POUW
  • FACTOR H POTENTIATING ANTIBODIES AND USES THEREOF
    Publication number: 20190194304
    Abstract: The invention relates to isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H. The invention further relates to the use of such antibodies and fragments for inhibiting complement activation and treatment of disorders associated with complement activation.
    Type: Application
    Filed: October 29, 2018
    Publication date: June 27, 2019
    Inventors: Taco Willem Kuijpers, Diana Wouters, Maria Clara Brouwer, Richard Benjamin Pouw
  • Factor H potentiating antibodies and uses thereof
    Patent number: 10112993
    Abstract: The invention relates to isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H. The invention further relates to the use of such antibodies and fragments for inhibiting complement activation and treatment of disorders associated with complement activation.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: October 30, 2018
    Assignee: STICHTING SANQUIN BLOEDVOORZIENING
    Inventors: Taco Willem Kuijpers, Diana Wouters, Maria Clara Brouwer, Richard Benjamin Pouw
  • FACTOR H POTENTIATING ANTIBODIES AND USES THEREOF
    Publication number: 20170355753
    Abstract: The invention relates to isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H. The invention further relates to the use of such antibodies and fragments for inhibiting complement activation and treatment of disorders associated with complement activation.
    Type: Application
    Filed: August 20, 2015
    Publication date: December 14, 2017
    Inventors: Taco Willem KUIJPERS, Diana WOUTERS, Maria Clara BROUWER, Richard Benjamin POUW
  • Means and methods for investigating nucleic acid sequences
    Patent number: 9017971
    Abstract: The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: April 28, 2015
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Taco Willem Kuijpers, Martin de Boer
  • Diagnostic methods involving determining gene copy numbers and SNPS in the Fc?RII/Fc?RIII gene cluster, and probes for use in such methods to detect susceptibility to and treatment efficacy in autoimmune diseases
    Patent number: 8765372
    Abstract: The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from said subject the amount of intact genes, or gene products thereof, of the Fc?RII/Fc?RIII gene cluster, said gene cluster comprising the FCGR2C, FCGR3A, FCGR2A and FCGR3B genes encoding an activating Fc?R, and FCGR2B encoding an inhibitory Fc?R; and correlating said amount to the amount observed in a healthy population. Also provided is a method to predict the responsiveness of a subject to therapy with intravenous immunoglobulin (IVIg) therapy or a monospecific biological, such as a humanized or human monoclonal antibody or a chimeric molecule, comprising the C-terminal Fc-tail of IgG.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: July 1, 2014
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Dirk Roos, Taco Willem Kuijpers
  • MEANS AND METHODS FOR INVESTIGATING NUCLEIC ACID SEQUENCES
    Publication number: 20130323735
    Abstract: The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid.
    Type: Application
    Filed: August 8, 2013
    Publication date: December 5, 2013
    Applicant: Stichting Sanquin Bloedvoorziening
    Inventors: Taco Willem Kuijpers, Martin de Boer
  • Means and methods for investigating nucleic acid sequences
    Publication number: 20120107812
    Abstract: The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid. The invention further provides improved calibrators which are particularly suitable for determining (pseudo)gene variants and copy number variation.
    Type: Application
    Filed: October 5, 2011
    Publication date: May 3, 2012
    Inventors: Taco Willem Kuijpers, Martin de Boer
  • MEANS AND METHODS FOR INVESTIGATING NUCLEIC ACID SEQUENCES
    Publication number: 20120003633
    Abstract: The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid.
    Type: Application
    Filed: November 5, 2009
    Publication date: January 5, 2012
    Inventors: Taco Willem Kuijpers, Martin de Boer
  • Diagnostic methods involving determining gene copy numbers and SNPs in the FcyRII/FcyRIII gene cluster, and probes for use in such methods to detect susceptibility to and treatment efficacy in autoimmune diseases
    Patent number: 7994300
    Abstract: The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from said subject the amount of intact genes, or gene products thereof, of the Fc?RII/Fc?RIII gene cluster, said gene cluster comprising the FCGR2C, FCGR3A, FCGR2A and FCGR3B genes encoding an activating Fc?R, and FCGR2B encoding an inhibitory Fc? R; and correlating said amount to the amount observed in a healthy population. Also provided is a method to predict the responsiveness of a subject to therapy with intravenous immunoglobulin (IVIg) therapy or a monospecific biological, such as a humanized or human monoclonal antibody or a chimeric molecule, comprising the C-terminal Fc-tail of IgG.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: August 9, 2011
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Dirk Roos, Taco Willem Kuijpers
  • DIAGNOSTIC METHODS INVOLVING DETERMINING GENE COPY NUMBERS AND SNPs IN THE FcyRll/FcyRlll GENE CLUSTER, AND PROBES FOR USE IN SUCH METHODS TO DETECT SUSCEPTIBILITY TO AND TREATMENT EFFICACY IN AUTOIMMUNE DISEASES
    Publication number: 20110189672
    Abstract: The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from said subject the amount of intact genes, or gene products thereof, of the Fc?RII/Fc?RIII gene cluster, said gene cluster comprising the FCGR2C, FCGR3A, FCGR2A and FCGR3B genes encoding an activating Fc?R, and FCGR2B encoding an inhibitory Fc?R; and correlating said amount to the amount observed in a healthy population. Also provided is a method to predict the responsiveness of a subject to therapy with intravenous immunoglobulin (IVIg) therapy or a monospecific biological, such as a humanized or human monoclonal antibody or a chimeric molecule, comprising the C-terminal Fc-tail of IgG.
    Type: Application
    Filed: February 2, 2011
    Publication date: August 4, 2011
    Applicant: STICHTING SANQUIN BLOEDVOORZIENING
    Inventors: Dirk Roos, Taco Willem Kuijpers
  • DIAGNOSTIC METHODS INVOLVING DETERMINING GENE COPY NUMBERS AND SNPs IN THE FcyRII/FcyRIII GENE CLUSTER, AND PROBES FOR USE IN SUCH METHODS TO DETECT SUSCEPTIBILITY TO AND TREATMENT EFFICACY IN AUTOIMMUNE DISEASES
    Publication number: 20090263795
    Abstract: The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from said subject the amount of intact genes, or gene products thereof, of the Fc?RII/Fc?RIII gene cluster, said gene cluster comprising the FCGR2C, FCGR3A, FCGR2A and FCGR3B genes encoding an activating Fc?R, and FCGR2B encoding an inhibitory Fc? R; and correlating said amount to the amount observed in a healthy population. Also provided is a method to predict the responsiveness of a subject to therapy with intravenous immunoglobulin (IVIg) therapy or a monospecific biological, such as a humanized or human monoclonal antibody or a chimeric molecule, comprising the C-terminal Fc-tail of IgG.
    Type: Application
    Filed: December 22, 2006
    Publication date: October 22, 2009
    Inventors: Dirk Roos, Taco Willem Kuijpers