Abstract: An object of the present invention is to provide a plastic ampule capable of suppressing volatilization and scattering of a drug solution and elution of plastic compounding ingredients into the drug solution, as well as suppressing whisker formation and deformation and damage of an opening when the plastic ampule is opened. A plastic ampule 10 according to the present invention includes a drug solution storage part 11 for storing a drug solution, a drug solution discharge tube 12 in communication with the drug solution storage part 11 and extending toward one side, and a top part 13 closing an end at the one side of the drug solution discharge tube 12, and the drug solution discharge tube 12 includes a fragile part 14 formed to have a thin thickness along a circumferential direction.

Abstract: An object of the present invention is to provide a plastic ampule capable of suppressing volatilization and scattering of a drug solution and elution of plastic compounding ingredients into the drug solution, as well as suppressing whisker formation and deformation and damage of an opening when the plastic ampule is opened. A plastic ampule 10 according to the present invention includes a drug solution storage part 11 for storing a drug solution, a drug solution discharge tube 12 in communication with the drug solution storage part 11 and extending toward one side, and a top part 13 closing an end at the one side of the drug solution discharge tube 12, and the drug solution discharge tube 12 includes a fragile part 14 formed to have a thin thickness along a circumferential direction.

Abstract: The present invention provides a propofol-containing fat emulsion that can be administered with reduced vascular pain without incorporating a local anesthetic such as lidocaine; and a process for producing the same. The fat emulsion comprises 0.1 to 5 w/v % of propofol, 2 to 20 w/v % of an oily component, 0.4 to 10 w/v % of an emulsifier and 0.02 to 0.3 w/v % of at least one compound selected from the group consisting of cyclodextrins, cyclodextrin derivatives and pharmacologically acceptable salts thereof, and is in the form of a fat emulsion.

Abstract: This invention provides a propofol-containing fat emulsion preparation including: 0.1 to 2 w/v % of propofol, 10 to 20 w/v % of an oily component, and 2 to 5 w/v % of an emulsifier, the weight of the oily component being in the range of about 5 to about 200 times the weight of propofol, the weight of the emulsifier being in the range of about 0.9 to about 50 times that of propofol, and the average size of emulsion particles being 180 nm or less, and a method for preparing the same. Propofol-containing fat emulsion preparation of this invention alleviates the vascular pain that occurs during the administration thereof without incorporating a local anesthetic, such as lidocaine or the like, therein.

Abstract: The present invention provides a pharmaceutical composition which can permit a sparingly water-soluble drug substance to be solubilized or dispersed in a pharmaceutically allowable liquid medium (e.g., fat emulsion, etc.), characterized in that said pharmaceutical composition contains (a) a base (e.g., polyethylene glycol, etc.), (b) a sparingly water-soluble drug substance and (c) a fatty acid or its pharmaceutically allowable salt. The pharmaceutical composition can be mixed with a pharmaceutically allowable liquid medium to produce a pharmaceutical preparation for administration, such as an injectable solution, etc., wherein mixing can be performed for a shortened period of time and the sparingly water-soluble drug substance can be uniformly solubilized or dispersed in a liquid medium.

Abstract: The present invention provides a propofol-containing fat emulsion comprising propofol, an oily component, and an emulsifier, and further comprising a predetermined amount of a stabilizer, such as phosphatidylglycerol in which a specific fatty acid is a constituent fatty acid component. The present invention also provides a pain-relieving propofol-containing fat emulsion, which is obtained by mixing a local anaesthetic in advance with the above-described propofol-containing fat emulsion of the invention.

Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartment separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.

Abstract: The present invention aims at providing an alimentative infusion liquid which has improved stability and preservability and can be administered through a peripheral vein. The infusion liquid contains sugars, amino acids, electrolytes and a fat emulsion at a specific mixing ratio and has a specific pH value and a titratable acidity. The alimentative infusion liquid of the present invention containing the above-described components has good preservability without suffering from precipitation, denaturation and the like problems. Further, since the pH value is adjusted to a specific level and the titratable acidity is retained low, administration of the infusion liquid through a peripheral vein does not cause troubles such as angialiga.

Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.

Abstract: Hydrophobically-modified bioadhesive polyelectrolytes containing a bioadhesive polyelectrolyte and a hydrophobic component are disclosed. Also disclosed are polyelectrolyte-agent compositions wherein the hydrophobically-modified bioadhesive polyelectrolyte is loaded with a pharmaceutically, cosmetically, or prophylactically acceptable agent. Suitable agents have hydrophobic and/or ionic character, and include drugs. The polyelectrolyte-agent compositions may be formulated for administration by topical, oral and/or systemic routes. Methods of administering such agents to an animal are also disclosed, and include administration of an effective amount of the polyelectrolyte-agent composition to the animal.

Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.

Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.