Patents by Inventor Tadao Shibutani
Tadao Shibutani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10570117Abstract: Phenylimidazole compounds of formula (1) shown below and pharmaceutically acceptable salts thereof: Also disclosed are a pharmaceutical composition and a lipoprotein lipase activator, each containing one of the phenylimidazole compounds.Type: GrantFiled: October 25, 2016Date of Patent: February 25, 2020Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Koushi Iwata, Tadao Shibutani, Satoshi Kido, Daisuke Mori, Hidenori Yoshioka, Hikaru Nakata, Akiko Ishimaru
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Publication number: 20180354930Abstract: Provided is a compound (chemotherapeutic agent) effective in the prevention and treatment of hyperlipidemia, obesity, or the like.Type: ApplicationFiled: October 25, 2016Publication date: December 13, 2018Inventors: Koushi Iwata, Tadao Shibutani, Satoshi Kido, Daisuke Mori, Hidenori Yoshioka, Hikaru Nakata, Akiko Ishimaru
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Patent number: 8895599Abstract: The present invention provides pharmaceutical compositions containing benzene compound(s) represented by General Formula (1) below and, particularly, LPL-activating compositions for use in hyperlipidemia therapeutic and preventive agents, anti-obesity agents, and the like: wherein R1, R2, R3 and R4 are as defined in the specification.Type: GrantFiled: June 28, 2013Date of Patent: November 25, 2014Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Irina Neagu, Michael Ohlmeyer, Vidyadhar M. Paradkar, Kurt W. Saionz, Koushi Iwata, Takashi Okamura, Tadao Shibutani
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Publication number: 20130296342Abstract: The present invention provides pharmaceutical compositions containing benzene compound(s) represented by General Formula (1) below and, particularly, LPL-activating compositions for use in hyperlipidemia therapeutic and preventive agents, anti-obesity agents, and the like: wherein R1, R2, R3 and R4 are as defined in the specification.Type: ApplicationFiled: June 28, 2013Publication date: November 7, 2013Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Irina NEAGU, Michael OHLMEYER, Vidyadhar M. PARADKAR, Kurt W. SAIONZ, Koushi IWATA, Takashi OKAMURA, Tadao SHIBUTANI
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Patent number: 8329739Abstract: [Object] To provide a pharmaceutical product (chemotherapeutic agent) effective in the prevention and treatment of hyperlipidemia, obesity, etc. [Solving Means] A phenylimidazole compound represented by the following General Formula (1): wherein, R1 represents a hydrogen atom, a phenyl lower alkyl group optionally having a substituent, or a pyridyl lower alkyl group optionally having a substituent, and the benzene ring and the pyridine ring are optionally substituted with 1 or 2 substituents selected from the group consisting of halogen atoms, cyano group and halogen-substituted lower alkyl groups. One of R2 and R3 represents a hydrogen atom and the other represents a lower alkoxy group. R4 represents a phenyl group optionally having a substituent. R5 and R6 are the same or different, and represent a hydrogen atom or a lower alkyl group. R7 and R8 are the same or different, and represent a hydrogen atom or a lower alkoxy group.Type: GrantFiled: February 3, 2010Date of Patent: December 11, 2012Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Tadao Shibutani, Koushi Iwata, Satoshi Kido
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Publication number: 20110275823Abstract: [Object] To provide a pharmaceutical product (chemotherapeutic agent) effective in the prevention and treatment of hyperlipidemia, obesity, etc. [Solving Means] A phenylimidazole compound represented by the following General Formula (1): wherein, R1 represents a hydrogen atom, a phenyl lower alkyl group optionally having a substituent, or a pyridyl lower alkyl group optionally having a substituent, and the benzene ring and the pyridine ring are optionally substituted with 1 or 2 substituents selected from the group consisting of halogen atoms, cyano group and halogen-substituted lower alkyl groups. One of R2 and R3 represents a hydrogen atom and the other represents a lower alkoxy group. R4 represents a phenyl group optionally having a substituent. R5 and R6 are the same or different, and represent a hydrogen atom or a lower alkyl group. R7 and R8 are the same or different, and represent a hydrogen atom or a lower alkoxy group.Type: ApplicationFiled: February 3, 2010Publication date: November 10, 2011Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Tadao Shibutani, Koushi Iwata, Satoshi Kido
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Publication number: 20110065728Abstract: The present invention provides pharmaceutical compositions containing benzene compound(s) represented by General Formula (1) below and, particularly, LPL-activating compositions for use in hyperlipidemia therapeutic and preventive agents, anti-obesity agents, and the like: wherein R1, R2, R3 and R4 are as defined in the specification.Type: ApplicationFiled: May 14, 2008Publication date: March 17, 2011Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Irina Neagu, Michael Ohlmeyer, Vidyadhar M. Paradkar, Kurt W. Saionz, Koushi Iwata, Takashi Okamura, Tadao Shibutani
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Patent number: 7071187Abstract: The present invention provides a novel naphthyridine derivative that is effective for relieving pain, less toxic, and also is effective for treating diabetic neuropathy, the derivative being represented by the general formula (1): wherein R1, R2, R3 and R4 are as described in the description.Type: GrantFiled: February 21, 2002Date of Patent: July 4, 2006Assignee: Otsuka Pharmaceutical Factory, Inc.Inventor: Tadao Shibutani
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Publication number: 20040214853Abstract: The present invention provides a novel naphthyridine derivative that is effective for relieving pain, less toxic, and also is effective for treating diabetic neuropathy, the derivative being represented by the general formula (1): 1Type: ApplicationFiled: February 18, 2004Publication date: October 28, 2004Inventor: Tadao Shibutani
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Patent number: 6372749Abstract: The present invention provides pyrazolo[1,5-a]pyrimidine derivatives represented by the formula (1) wherein R1 represents lower alkyl or the like; one of R2 and R3 represents hydrogen and the other represents phenyl having lower alkoxy or the like, and R4 is hydrogen, carboxyl, lower alkoxy-carbonyl or the like. The derivatives of the invention have pharmacological effects such as analgesic action, inhibitory effect on nitrogen monoxide synthetase and the like and are useful as analgesics. The derivatives of the invention are also useful as therapeutic or prophylactic agents for septicemia, endotoxin shock, chronic articular rheumatism, etc.Type: GrantFiled: November 20, 2000Date of Patent: April 16, 2002Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Takashi Okumura, Yasuo Shoji, Tadao Shibutani, Tsuneo Yasuda, Takeshi Iwamoto
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Patent number: 6245779Abstract: The present invention provides a naphthyridine derivative represented by the formula (1) wherein A is lower alkylene; R1 is H or an electron pair “-”; R2 is optionally substituted phenyl; when R1 is an electron pair “-”, R3 is a group represented by (wherein R4 and R5 each represent lower alkyl, etc.); when R1 is H, R3 is a group —S—R6 (wherein R6 is lower alkyl, etc.); and R7 is H or lower alkyl; and also provides an analgesic composition containing the above derivative as an active ingredient.Type: GrantFiled: December 9, 1999Date of Patent: June 12, 2001Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Tadao Shibutani, Yasuo Shoji, Takashi Okamura, Tsuneo Yasuda, Takeshi Iwamoto
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Patent number: 6166016Abstract: The invention provides amide derivatives which are useful as analgesics, anti-inflammatory agents, antimicrobial drugs, hypoglycemic agents, hypolipidemic agents, antihypertensive agents, anti-cancer agents, etc., the derivatives being represented by the formula ##STR1## wherein ring A represents a benzene ring, a naphthalene ring, a pyridine ring or a furan ring; R.sup.4 represents a heterocyclic group selected from the group consisting of a lower alkyl-substituted thieno[3,2-d]pyrimidin-4-yl group, an optionally substituted pyrazolo[1,5-a]-1,3,5-triazin-4-yl group, a pyrazolo[3,4-d]pyrimidin-4-yl group substituted at the 6-position and a purin-6-yl group substituted at the 2-position; and R.sup.Type: GrantFiled: December 2, 1998Date of Patent: December 26, 2000Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Takashi Okamura, Yasuo Shoji, Tadao Shibutani, Tsuneo Yasuda, Takeshi Iwamoto