Abstract: A compound represented by the general formula (I) or a salt thereof having a potent antibacterial activity against bacteria that have acquired resistance to quinolones, and a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing the compound or a salt thereof as an active ingredient, as well as a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing a combination of the compound or a salt thereof, and a quinolone.

Abstract: An antibacterial agent comprising a compound represented by the following general formula (I), which can exhibit potent antibacterial activity against bacteria that have acquired resistance to quinolones (in the formula, R1 and R4 represents hydrogen atom, hydroxyl group, or a lower alkoxy group; R2 and R3 represents hydrogen atom or hydroxyl group; R5 represents hydrogen atom, a lower cyclic alkyl group, or a lower alkoxy group; R1? and R5? represents hydrogen atom; R2? and R3? represents hydrogen atom, hydroxyl group, or a lower alkoxy group; and R4? represents hydrogen atom or hydroxyl group).

Abstract: An antibacterial agent comprising a compound represented by the following general formula (I), which can exhibit potent antibacterial activity against bacteria that have acquired resistance to quinolones (in the formula, R1 and R4 represents hydrogen atom, hydroxyl group, or a lower alkoxy group; R2 and R3 represents hydrogen atom or hydroxyl group; W represents hydrogen atom, a lower cyclic alkyl group, or a lower alkoxy group; R1? and R5? represents hydrogen atom; R2? and R3? represents hydrogen atom, hydroxyl group, or a lower alkoxy group; and R4? represents hydrogen atom or hydroxyl group).

Abstract: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.

Abstract: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.

Abstract: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.

Abstract: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.

Abstract: A rotational coupling device for a cordless dental instrument including a motor housing which has a pair of semi-annular projections integrally provided at a rear end thereof with a pair of arc-shaped recesses formed between the coupling projections and semi-annular slot provided around the inner peripheries of the semi-annular projections. A battery housing has a pair of semi-annular around an outer periphery adjacent its front end, a pair of arc-shaped projections coinciding with the arc-shaped recesses of the motor housing and a pair of semi-annular flanges coinciding with the pair of semi-annular projections of the motor housing so as to form a rotational coupling between the motor housing and the battery housing. An insulating disc having a pair of contacts connected to a motor fits into a rear opening of the motor housing.

Abstract: A dental handpiece has a handle portion including a powerhead assembly integrally supported on a front end of the handle portion and a base cylindrical member located in a cylindrical hollow portion of the handle portion. The base cylindrical member has a first axial central passage for a fiberscope, a second side passage for supplying air under pressure, a third side passage for supplying water and a fourth passage for exhaust. A middle connector has a large diameter front hollow portion and a small diameter rear hollow portion having internal threads, three radial openings provided through the connector at equally spaced locations, passages corresponding to the passages in the base cylindrical member and a tubular plunger slidably mounted thereon. A driven ball and a driving ball are slidably located in each radial opening for engaging a circumferential slot around an external rear end portion of a hollow mount insert threadedly fitted into the rear end portion of the base cylindrical member.