Abstract: An objective-optical-system positioning apparatus includes a positioning unit interposed between an objective optical system having a small-diameter end section and an examination optical system for examining light collected by the objective optical system; and a substantially cylindrical support unit, one end of which is secured to an organism, and which internally supports the small-diameter end section in a detachable manner. The positioning unit includes a holding part for holding the objective optical system and a moving mechanism supporting the holding part such that the holding part is freely movable in a direction intersecting with a direction of an optical axis of the objective optical system, and the other end of the support unit has a tapered inner surface whose diameter gradually increases toward the tip.

Abstract: Aberrations are sufficiently corrected, and an excellent image is acquired. Provided is a variable-focus optical system including a positive-power front-group optical system, a rear-group optical system having the same power, and an optical-system driving unit configured to relatively change the distance therebetween in the optical axis direction, wherein the front-group optical system consists of a positive-power first-group optical system formed of a joined lens, that is, a lens L1 and a lens L2, a positive-power second-group optical system consisting of a lens L3, and a third-group optical system formed of a lens L4 and a lens L5, and the rear-group optical system consists of a positive-power fourth-group optical system formed of a lens L7 and a lens L6, a fifth-group optical system consisting of a positive-power lens L8, and a positive-power sixth-group optical system formed of a joined lens, that is, a lens L10 and a lens L9.

Abstract: High-precision observation is made possible while allowing contact between a distal end of an objective lens and an optical element without damaging the distal end of the objective lens and the optical element even when attaching to and detaching from the distal end of the objective lens. Provided is an objective lens adapter including a fixed member that is fixed to a lens tube of an objective lens, a distal-end member including an optical element that is made to be placed in contact with the distal-end surface of the objective lens, and an elastic member that is disposed between the distal-end member and the fixed member and that urges the optical element in a direction that causes the optical element to contact the distal-end surface of the objective lens.

Abstract: It is possible to use the magnification of an objective lens as is, substantially without changing the observation magnification, even when the working distance of the objective lens is changed. The invention provides a focus-adjusting unit disposed on an optical axis between an objective optical system that collects light from a specimen and an image-forming optical system that images the light collected by the objective optical system at a prescribed position, comprising a front optical system and a back optical system, sequentially disposed along the optical axis direction from a front side, with the objective optical system serving at the front side and the image-forming optical system at the back; and a lens driving part that relatively moves these optical systems in the optical axis direction, wherein the front optical system and the back optical system have refractive powers of different sign and focal lengths of substantially equal absolute value.

Abstract: An objective-optical-system positioning apparatus includes a positioning unit interposed between an objective optical system having a small-diameter end section and an examination optical system for examining light collected by the objective optical system; and a substantially cylindrical support unit, one end of which is secured to an organism, and which internally supports the small-diameter end section in a detachable manner. The positioning unit includes a holding part for holding the objective optical system and a moving mechanism supporting the holding part such that the holding part is freely movable in a direction intersecting with a direction of an optical axis of the objective optical system, and the other end of the support unit has a tapered inner surface whose diameter gradually increases toward the tip.

Abstract: An object is to easily and reliably reach an examination site. The present invention provides an examination method of carrying out in-vivo examination using an in-vivo examination apparatus capable of fluorescence examination and reflected-light examination and includes the steps of setting a reference position so as to set an examination site by carrying out reflected-light examination, switching from reflected-light examination to fluorescence examination, and moving from the reference position to the examination site.

Abstract: A microscope examination apparatus including a light source; an illumination optical system configured to guide light from the light source to a specimen; an objective lens configured to collimate return light from the specimen, the objective lens being provided in such a manner as to be displaceable at least in a direction intersecting an optical axis of the objective lens; an image-forming lens configured to image the return light from the specimen, which is collimated by the objective lens; an optical detector configured to detect the return light imaged by the image-forming lens; a microscope main body including the image-forming lens and the optical detector; and an objective-lens driving mechanism configured to drive the objective lens in a direction correcting image blur due to a displacement of the specimen.

Abstract: An end face of a narrow-diameter end portion is easily disposed at a correct position on an examination object without setting an examination site, thus enabling rapid and straightforward acquisition of an image of the examination site. The invention provides an alignment method for a guiding device which is attached to an end of an objective lens in such a manner as to be capable of positional adjustment in an optical axis direction and which is brought into contact with an examination target to make a focal position of the objective lens coincident with an examination site.

Abstract: Especially when observing brain tissue, damage inflicted on the brain tissue is reduced, and light from the brain tissue is collected to the utmost extent. The invention provides an objective lens in which a tip transparent member that is made to contact an observation object is formed to gradually narrow towards an end face thereof, a diameter d of the end face being defined by the following expression, and a maximum diameter D being 3 mm or less: 0 mm?d?FOV?2×WD×(NA/N)?0.3 mm where FOV is the observation field of view, WD is the working distance, NA is the numerical aperture, and N is the refractive index of the observation object.

Abstract: An optical scanning observation apparatus having an internal focusing mechanism. suitable for in-vivo observation of animals, is provided. The optical scanning observation apparatus includes a light source, an objective optical system for focusing light onto the sample, a detection-light splitting device for splitting off collected detection light, a detector for detecting the focused detection light, a focus scanning device disposed between the detection-light splitting device and the objective optical system, and a lateral-direction scanning device, disposed between the focus scanning device and the objective optical system, for scanning the light in orthogonal directions relative to the optical axis. The focus scanning device further includes a focusing optical system having a positive and negative lens group and a lens driving device for moving one lens group to adjust the working distance of the objective optical system.

Abstract: High-precision observation is made possible while allowing contact between a distal end of an objective lens and an optical element without damaging the distal end of the objective lens and the optical element even when attaching to and detaching from the distal end of the objective lens. Provided is an objective lens adapter including a fixed member that is fixed to a lens tube of an objective lens, a distal-end member including an optical element that is made to be placed in contact with the distal-end surface of the objective lens, and an elastic member that is disposed between the distal-end member and the fixed member and that urges the optical element in a direction that causes the optical element to contact the distal-end surface of the objective lens.

Abstract: A compact optical unit which comprises a light emitting section for emitting a light, a first optical element having a first reflecting section for reflecting a light which is emitted from the light emitting section, a second optical element having a second reflecting section which is disposed to face the first optical element, and a light condensing optical system for condensing a light is formed. The first reflecting section and the second reflecting section are disposed so as to be diagonal to an optical axis of a light which is incident to the first reflecting section and the second reflecting section, a light transmitting section is disposed in the first optical element for transmitting a light which is reflected by the second reflecting section so as to be incident to the light condensing optical system.

Abstract: The invention provides a microscope examination apparatus including a light source; an illumination optical system configured to guide light from the light source to a specimen; an objective lens configured to collimate return light from the specimen, the objective lens being provided in such a manner as to be displaceable at least in a direction intersecting an optical axis of the objective lens; an image-forming lens configured to image the return light from the specimen, which is collimated by the objective lens; an optical detector configured to detect the return light imaged by the image-forming lens; a microscope main body including the image-forming lens and the optical detector; and an objective-lens driving mechanism configured to drive the objective lens in a direction correcting image blur due to a displacement of the specimen.

Abstract: It is possible to use the magnification of an objective lens as is, substantially without changing the observation magnification, even when the working distance of the objective lens is changed. The invention provides a focus-adjusting unit disposed on an optical axis between an objective optical system that collects light from a specimen and an image-forming optical system that images the light collected by the objective optical system at a prescribed position, comprising a front optical system and a back optical system, sequentially disposed along the optical axis direction from a front side, with the objective optical system serving at the front side and the image-forming optical system at the back; and a lens driving part that relatively moves these optical systems in the optical axis direction, wherein the front optical system and the back optical system have refractive powers of different sign and focal lengths of substantially equal absolute value.

Abstract: An optical scanning microscope is provided in which the observation magnification does not greatly change even when the working distance of an objective lens is changed. The optical scanning microscope includes an objective optical system that converts the light from a specimen into a substantially collimated light beam, an imaging optical system that forms an image from the substantially collimated light beam from the objective optical system at a predetermined position, a pupil projection optical system that substantially collimates the light formed into an image by the imaging optical system at the predetermined position, a lateral scanner that angularly deflects the substantially collimated light beam from the pupil projection optical system to laterally scan the area of the specimen to be observed, and a lens driver that drives the imaging optical system or the pupil projection optical system or both in the optical axis direction.

Abstract: The present invention makes an objective lens easier to handle during disinfection or sterilization and protects the objective lens during, for example, transport, storage, or handling. The present invention provides an objective-lens protector including a substantially ring-shaped mounting portion surrounding a circumference of an objective lens, the mounting portion detachably mounted on the objective lens such that a threaded mount formed on the objective lens for mounting the objective lens to a microscope main body is exposed; a protecting member fixed to the mounting portion, extending substantially along the entire length of the objective lens mounted on the mounting portion, and arranged at a distance outwardly in a radial direction of the objective lens so as to surround the objective lens; and a locking mechanism provided on the mounting portion to prevent the objective lens from moving relative to the mounting portion in a circumferential direction.

Abstract: A control portion of an optical image pickup apparatus includes a scan driver, a lock-in amplifier, and an A/D converter. The scan driver outputs a predetermined drive signal to a Y-scanning mirror and an X-scanning mirror and scans the Y-scanning mirror and the X-scanning mirror. The lock-in amplifier detects a signal level Vout of a frequency component of the drive signal of the scan driver among signals detected by a detector portion. The A/D converter converts a signal detected by a detector portion and a signal level of the detected signal of a frequency component of a drive signal detected by the lock-in amplifier to digital signals and outputs the digital signals to an image processor. Thus, mirror scan operations of the scanning mirrors can be securely detected.

Abstract: The invention provides a compact optical scanning observation apparatus having an internal focusing mechanism and which is suitable for in-vivo observation of animals. The optical scanning observation apparatus comprises a light source for illuminating a sample; an objective optical system for focusing illumination light onto the sample; a detection-light splitting device for splitting off collected detection light from the illumination light; a detection-light focusing optical system for focusing the split-off detection light; a detector for detecting the focused detection light; a focus scanning device disposed between the detection-light splitting device and the objective optical system; and a lateral-direction scanning device, disposed between the focus scanning device and the objective optical system, for scanning the illumination light from the light source on the sample, in substantially orthogonal directions with respect to the optical axis.

Abstract: When the user inserts an insertion end portion of an image forming unit covered with a protective cover into an attachment opening on an apparatus main unit along with a buffer sheet and a blackout sheet, the insertion end portion of an exterior cover sheet touches an exterior wall near the attachment opening for the image forming unit on the apparatus main unit. Thereby, the insertion operation of the image forming unit stops and one end of the image forming unit is held supported on the wall inside the opening.

Abstract: An end face of a narrow-diameter end portion is easily disposed at a correct position on an examination object without setting an examination site, thus enabling rapid and straightforward acquisition of an image of the examination site. The invention provides an alignment method for a guiding device which is attached to an end of an objective lens in such a manner as to be capable of positional adjustment in an optical axis direction and which is brought into contact with an examination target to make a focal position of the objective lens coincident with an examination site.