Abstract: A method of treating a disease that is treatable through inhibition of at least one kinase selected from the group consisting of CDK7, CDK4, CDK6, PIM2, TSSK3, MST4, NEK6, MAP3K, MST3, DDR1, SPHK1, CaMK1, AurA, BRK, CaMK4, and PIM1, the method comprising administering an effective dose of a compound represented by the following formula (1) or a salt thereof to a patient:

Abstract: Provided is an inhibitor for at least one kind of kinase selected from the group consisting of CDK7, CDK4, CDK6, PIM2, TSSK3, MST4, NEK6, MAP3K, MST3, DDR1, SPHK1, CaMK1, AurA, BRK, CaMK4, and PIM1, the inhibitor including as an active ingredient a compound represented by the following general formula (1) or a salt thereof: in the general formula (1), R1, R2, R3, R4, R5, and R6 are as described in Description.

Abstract: A substance contains a phosphatidylinositol-3-kinase (PI3K) inhibitor including a depsipeptide-class compound represented by formula (1), or a physiologically acceptable salt thereof that combines a PI3K inhibitory effect and an HDAC inhibitory effect to provide an anti-cancer pharmaceutical composition for the treatment of an intractable cancer.

Abstract: A substance contains a phosphatidylinositol-3-kinase (PI3K) inhibitor including a depsipeptide-class compound represented by formula (1), or a physiologically acceptable salt thereof that combines a PI3K inhibitory effect and an HDAC inhibitory effect to provide an anti-cancer pharmaceutical composition for the treatment of an intractable cancer.

Abstract: The present invention relates to compounds of formula (I) and a process for producing the same. In formula (I), X represents a halogen atom, and R1 represents group —COR2 wherein R2 represents group OM or C1-12 alkyloxy wherein M represents a hydrogen atom, an alkali metal, an alkaline earth metal, or quaternary ammonium. The use of this compound as a synthetic intermediate can realize the production of carbapenem derivatives having potent antimicrobial activity in an efficient and safe manner at low cost.

Abstract: The present invention relates to compounds of formula (I) and a process for producing the same. In formula (I), X represents a halogen atom, and R1 represents group —COR2 wherein R2 represents group OM or C1-12 alkyloxy wherein M represents a hydrogen atom, an alkali metal, an alkaline earth metal, or quaternary ammonium. The use of this compound as a synthetic intermediate can realize the production of carbapenem derivatives having potent antimicrobial activity in an efficient and safe manner at low cost.

Abstract: A scheme for providing environmental information to users is disclosed. In this scheme, environmental information is measured automatically by each of a plurality of environment sensors arranged at a plurality of regions, and the environmental information measured by each environment sensor is collected automatically to a base device, and stored at the base device. Then, the environmental information is processed at the base device according to a user information of an individual user, and processed environmental information is provided from the base device to the individual user through a network connecting the users and the base device.

Abstract: Intermediates for the preparation of himbacine exhibiting muscarinic M2 receptor antagonism, which are hydronaphtho[2,3-c]furan derivatives represented by general formula (1) or intermediates for the preparation thereof: wherein R1 is lower alkyl or aralky; R2 is hydrogen, lower alkyl or aralkyl; R3 and R4 together represent oxygen or methylene, or alternatively R4 is hydroxyl, lower alkoxy, aralkyloxy or lower acyloxy, with R3 being hydrogen; R5 and R6 together represent oxygen, or alternatively R6 is hydroxyl, lower alkxy, aralkyloxy or lower acyloxy, with R5 being hydrogen; and either of the broken lines is a single bond and the other thereof is a double bond, or alternatively both are single bonds.

Abstract: A scheme for providing environmental information to users is disclosed. In this scheme, environmental information is measured automatically by each of a plurality of environment sensors arranged at a plurality of regions, and the environmental information measured by each environment sensor is collected automatically to a base device, and stored at the base device. Then, the environmental information is processed at the base device according to a user information of an individual user, and processed environmental information is provided from the base device to the individual user through a network connecting the users and the base device.

Abstract: To suitably keep the weight balance of an engine while reducing a radial dimension of the engine. A crank shaft and a transmission shaft are supported in casings and are disposed to be substantially parallel to each other. A rear balancer and a front balancer are disposed with the crank shaft placed therebetween. An AC generator is disposed at an end portion of the crank shaft on the left side with respect to a plane passing through a center of gravity of an engine and being perpendicular to the crank shaft. A clutch is disposed at an end portion of the transmission shaft on the right side with respect to the plane. The clutch is separated from the plane at a distance smaller than that between the AC generator and the plane, so that the weight balance of the engine is suitably maintained by disposing the rear balancer and the front balancer on the clutch side.

Abstract: An oil pressure monitoring system for an engine having an oil pressure switch comprising a piston located in a port associated with the lubricating system of the engine. The piston is biased into the port by means of a spring. Located between the piston and the wall of the port so as to undergo compression with movement of the piston into the port is an elastic, electrical conductor ring. The ring is placed in series in a warning circuit and is so constructed that compression of the ring resulting from a drop in oil pressure within the lubricating system will affect conductivity through the ring to initiate a warning signal.