Abstract: A device and a system for humor component detection are capable of continuously carrying out measurement with accuracy for a long time and are excellent from the aspect of good hygiene. The humor component detection system comprises the humor component detection device and an extra-corporeal sensing device. The humor component detection device comprises a biosensor, a microbe containing portion, and an outer shell. Here, the biosensor comprises a sensing element and an electronic device. The microbe containing portion includes a pouched microtube blanketing film into which the electrodes of the sensing element are inserted, a plurality of acinous polymer-filmed porous microcapsules contained inside the film, and GOD genetically-modified bacteria contained in the microcapsules.

Abstract: An air purification system comprises: a duct working as an air-flow path; an air-conditioning unit having an air purification filter provided on the duct; and a blower fun. The air purification filter contains an antibody material. The antibody material comprises: the blood components of a livestock animal which is administered desired antigens such as bacteria, mold, virus and environmental allergen; and/or a livestock food product containing that blood components. The blood components and the livestock food products are contained in the antibody material as effective components.

Abstract: Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R1 is lower alkyl; R2 is alkyl or aralkyl; and X1 is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.

Abstract: Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R1 is lower alkyl; R2 is alkyl or aralkyl; and X1 is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.

Abstract: A method of detecting a ligand or a ligand-like low-molecular weight compound from among test compounds characterized by separating a ligand-dependent cell line having a ligand receptor gene and an antibiotic resistance gene transferred thereinto from other cell lines, culturing the cell line in the presence of the test compounds and then examining the proliferation ability of the cells. Use of this method makes it possible to exactly screen a ligand (a physiologically active substance) or a low-molecular weight compound having the same action by a simple procedure.

Abstract: A method of producing biologically active substances using a hybrid cell line obtained by fusing (1) a human tumor cell line which does not grow in a medium containing aminopterin or/and azaserine or cell line derived therefrom with (2) a human non-tumor macrophage. The human tumor macrophage cell line may be either a thymidine kinase-deficient cell line of U-937 or a thymidine kinase-deficient cell line of THP-1, the non-tumor macrophage may be alveolar macrophage, splenic macrophage, peripheral blood monocyte, peritoneal macrophage, hepatic macrophage, placental macrophage, or thymic macrophage, and the biologically active substance produced is a tumoricidal substance or interleukin-1.