Abstract: The present invention relates to a DNA methylation marker for predicting the recurrence of liver cancer by using the difference in the DNA methylation levels according to a liver cancer prognosis, and when the marker is used, the recurrence of liver cancer can be easily predicted, and a more personalized treatment for patients at high risk of liver cancer recurrence can be provided and clinical information for avoiding unnecessary over-treatment can be provided.

Abstract: The present invention relates to a method for assessing the prognosis or risk stratification of liver cancer by using a clinical specimen mixed with a normal tissue, wherein at least one CpG site that shows a low methylation level in normal and blood tissues but a high methylation level in only a cancer tissue is measured for methylation level.

Abstract: The present invention relates to a method for assessing the prognosis or risk stratification of liver cancer by using a clinical specimen mixed with a normal tissue, wherein at least one CpG site that shows a low methylation level in normal and blood tissues but a high methylation level in only a cancer tissue is measured for methylation level.

Abstract: Provided are a method and an apparatus for preparing medicines. The method for preparing medicines includes a distribution step of distributing at least one pill into at least one medicine packet and a crushing step of applying a pressure to the medicine packet with the pill to crush the pill. The apparatus for preparing medicines includes a distributor configured to distribute at least one pill into at least one medicine packet and a crusher configured to apply a pressure to the medicine packet with the pill to crush the pill.

Abstract: Provided are a method and an apparatus for preparing medicines. The method for preparing medicines includes a distribution step of distributing at least one pill into at least one medicine packet and a crushing step of applying a pressure to the medicine packet with the pill to crush the pill. The apparatus for preparing medicines includes a distributor configured to distribute at least one pill into at least one medicine packet and a crusher configured to apply a pressure to the medicine packet with the pill to crush the pill.

Abstract: Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is “turned on” only under such conditions.

Abstract: Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is “turned on” only under such conditions.

Abstract: Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is “turned on” only under such conditions.

Abstract: Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is “turned on” only under such conditions.