Abstract: Provided herein are compositions and methods for treating and/or preventing neurodegenerative disease, such as Alzheimer's disease. In particular aspects, compositions administered herein encode a cellular immune response element. The compositions may be prepared and administered in such a manner that the cellular immune response element coding sequence is expressed in the subject to which the composition is administered. The compositions include expression systems, delivery systems, and certain cellular immune response element genes.

Abstract: Provided herein are compositions and methods for treating and/or preventing neurodegenerative disease, such as Alzheimer's disease. In particular aspects, compositions administered herein encode a cellular immune response element. The compositions may be prepared and administered in such a manner that the cellular immune response element coding sequence is expressed in the subject to which the composition is administered. The compositions include expression systems, delivery systems, and certain cellular immune response element genes.

Abstract: The present invention provides a method of treating or preventing a disease or condition in a patient comprising intravenously administering a therapeutically effective amount of mesenchymal stem cells to the patient, wherein the disease or condition is osteoarthritis, rheumatoid arthritis, multiple sclerosis, stroke, ulcerative colitis, psoriasis, Hashimoto's thyroiditis, atopic dermatitis, allergic rhinitis, chronic obstructive pulmonary disease with bronchial asthma or hearing loss.

Abstract: The present invention relates to compositions and methods for restoring hearing loss. In particular aspects, the invention relates to the administration of compositions that encode an inflammatory response control element. The compositions are prepared and administered in such a manner that the inflammatory response control element coding sequence is expressed in the subject to which the composition is administered. The compositions include expression systems, delivery systems, and certain inflammatory response control genes.

Abstract: The present invention relates to compositions and methods for restoring hearing loss. In particular aspects, the invention relates to the administration of compositions that encode an inflammatory response control element. The compositions are prepared and administered in such a manner that the inflammatory response control element coding sequence is expressed in the subject to which the composition is administered. The compositions include expression systems, delivery systems, and certain inflammatory response control genes.

Abstract: Vaccination with the DNA encoding T-cell epitopes to the house dust mite Dermatophagoides pteronyssimus (Der p) and Dermatophagoides farinae (Der f were effective in the inhibition of the allergen induced IgE synthesis. Gene therapy using T-cell epitope encoding DNA is useful in combating allergic disease.

Abstract: Provided herein are compositions and methods for treating and/or preventing neurodegenerative disease, such as Alzheimer's disease. In particular aspects, compositions administered herein encode a cellular immune response element. The compositions may be prepared and administered in such a manner that the cellular immune response element coding sequence is expressed in the subject to which the composition is administered. The compositions include expression systems, delivery systems, and certain cellular immune response element genes.

Abstract: Vaccination with the DNA encoding T-cell epitopes to the house dust mite Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f were effective in the inhibition of the allergen induced IgE synthesis. Gene therapy using T-cell epitope encoding DNA is useful in combating allergic disease.

Abstract: A 28 kD antigen present in the intracellular signal transduction oncogene and an immunoassay method for diagnosing Systemic Lupus Erythematosis using the 28 kD antigen as a target substance for detecting target binding substance in biological fluid from an animal or human having symptoms of Systemic Lupus Erythematosis.

Abstract: Methods for diagnosing and monitoring autoimmune inner ear diseases such as Meniere's disease by combining a sample with one or more antigens and detecting the binding of antibodies in the sample to the antigen. The antigen is an inner ear collagen protein or peptide including type II collagen, type IX collagen, or type XI collagen. Binding is detected using an assay method such as an ELISA immunoassay. The assay may further include one or more additional inner ear antigens such as the signal transduction protein Raf-1, the myelin protein P0 and &bgr;-tubulin.

Abstract: A 28 kD antigen present in the membranous structure of the inner ear and an immunoassay method for diagnosing Meniere's disease using the 28 kD antigen as a target substance for detecting target binding substance in biological fluid from an animal or human having symptoms of a disease of the inner ear.