Patents by Inventor Takaaki HIROTSU

Takaaki HIROTSU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230408496
    Abstract: The present invention provides a method for analyzing a blood sample. According to the present invention, there is provided, for example, a method for testing or analyzing a blood sample from a subject having cancer or suspected of having cancer, including evaluating taxis behavior of nematodes to the blood sample. According to the present invention, there is provided, for example, a method for evaluating whether a subject has cancer or not by the above method.
    Type: Application
    Filed: November 16, 2021
    Publication date: December 21, 2023
    Applicant: Hirotsu Bio Science Inc.
    Inventor: Takaaki HIROTSU
  • Patent number: 11725226
    Abstract: The present invention provides a method for highly sensitively and highly specifically detecting a kidney cancer. According to the present invention, there is provided, for example, a method for detecting a kidney cancer in a subject, comprising diluting a urine sample obtained from the subject at a predetermined ratio, and determining whether or not nematodes exhibit attraction behavior toward the diluted urine sample, wherein the predetermined ratio is 200 or more.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: August 15, 2023
    Assignees: HIROTSU BIO SCIENCE INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Takaaki Hirotsu, Hirofumi Jono
  • Patent number: 11719698
    Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: August 8, 2023
    Assignee: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki Hirotsu, Hideto Sonoda
  • Publication number: 20230204590
    Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
    Type: Application
    Filed: March 9, 2023
    Publication date: June 29, 2023
    Applicant: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki HIROTSU, Hideto SONODA
  • Publication number: 20230084843
    Abstract: To provide a research result distribution platform that is highly convenient for researchers and people trying to use research results. A research result acquisition unit acquires research result information indicating results of research of researchers. A management unit manages one or more pieces of research result information acquired by the research result acquisition unit, for each researcher. An extraction unit extracts the research result information desired by a user from the one or more pieces of research result information managed by the management unit. A research result presentation unit presents the research result information extracted by the extraction unit to the user. The problem is solved thereby. For both researchers and users, gaining and losing of service points to make the research result distribution platform more active is controlled.
    Type: Application
    Filed: November 17, 2022
    Publication date: March 16, 2023
    Inventors: Takaaki HIROTSU, Naoki SAKAKIBARA
  • Patent number: 11479800
    Abstract: The present invention provides a method for detecting cancer using a tissue specimen. Specifically, for example, there is provided a method for detecting cancer in an organ or tissue having cancer, comprising: preparing a cell lysate from a region suspected to be cancer isolated from the organ or tissue; and evaluating a tactic behavior of a nematode for the cell lysate.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: October 25, 2022
    Assignees: HIROTSU BIO SCIENCE INC., NANPUH HOSPITAL
    Inventors: Takaaki Hirotsu, Takuma Yoshinaga
  • Publication number: 20220147939
    Abstract: To provide a research result distribution platform that is highly convenient for researchers and people trying to use research results. A research result acquisition unit 111 acquires research result information indicating results of research of researchers R. A management unit 102 manages one or more pieces of research result information acquired by the research result acquisition unit 111, for each researcher R. An extraction unit 103 extracts the research result information desired by a user U from the one or more pieces of research result information managed by the management unit 102. A research result presentation unit 141 presents the research result information extracted by the extraction unit 103 to the user U. The problem is solved thereby.
    Type: Application
    Filed: May 28, 2020
    Publication date: May 12, 2022
    Inventors: Takaaki HIROTSU, Naoki SAKAKIBARA
  • Publication number: 20210356470
    Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
    Type: Application
    Filed: April 27, 2021
    Publication date: November 18, 2021
    Applicant: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki HIROTSU, Hideto SONODA
  • Patent number: 11150234
    Abstract: The present invention provides a method for evaluating the taxic behavior of nematodes in response to an odor substance based on olfactory sense, and a dish and a behavior evaluation system to be used for the evaluation method. [Solution] Provided is a method for evaluating the taxic behavior of nematodes in response to odor of a test sample, the method including: a) providing a dish in which the test sample is arranged on the bottom surface, and nematodes are arranged in a region or a site of the bottom surface 1 cm to 3 cm away from the test sample; b) observing the arrangement of the nematodes on the bottom surface at 3 to 15 minutes after the later one of the test sample or the nematodes is arranged; and c) evaluating whether the nematodes show attraction behavior or avoidance behavior in response to the test sample, from the arrangement of the nematodes observed, and a dish or a taxic behavior evaluation system suitable for the method.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: October 19, 2021
    Assignee: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki Hirotsu, Takayuki Uozumi, Satoru Kaifuchi
  • Publication number: 20210215669
    Abstract: A method of examining for cancer in a non-primate mammal such as a pet animal may include, for example, a method of examining or diagnosing for cancer in a non-primate mammal, including evaluating taxic behavior of nematodes toward a urine sample from a subject mammal.
    Type: Application
    Filed: August 14, 2019
    Publication date: July 15, 2021
    Applicant: Hirotsu Bio Science Inc.
    Inventors: Takaaki HIROTSU, Satoru KAIFUCHI, Toshimi SUGIMOTO, Hideshi ISHII, Masamitsu KONNO, Yuji UEDA, Shogo KOBAYASHI, Hidetoshi EGUCHI, Yuichiro DOKI, Masaki MORI
  • Publication number: 20200400653
    Abstract: The present invention provides a method for predicting a therapeutic effect and/or monitoring recurrence in a cancer patient. Disclosed is a method for detecting a therapeutic effect of cancer treatment in a cancer patient, comprising: measuring nematode tactic behavior to each of pre-treatment urine and in-treatment or post-treatment urine from the cancer patient; and comparing a result of measuring the tactic behavior to the pre-treatment urine and a result of measuring the tactic behavior to the in-treatment or post-treatment urine, wherein when attraction is weakened or avoidance is strengthened after the treatment, it is determined that the therapeutic effect is detected.
    Type: Application
    Filed: March 30, 2018
    Publication date: December 24, 2020
    Applicants: HIROTSU BIO SCIENCE INC., NANPUH HOSPITAL
    Inventor: Takaaki HIROTSU
  • Publication number: 20200208192
    Abstract: The present invention provides a method for highly sensitively and highly specifically detecting a kidney cancer. According to the present invention, there is provided, for example, a method for detecting a kidney cancer in a subject, comprising diluting a urine sample obtained from the subject at a predetermined ratio, and determining whether or not nematodes exhibit attraction behavior toward the diluted urine sample, wherein the predetermined ratio is 200 or more.
    Type: Application
    Filed: August 20, 2018
    Publication date: July 2, 2020
    Applicants: HIROTSU BIO SCIENCE INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Takaaki HIROTSU, Hirofumi JONO
  • Publication number: 20200165655
    Abstract: The present invention provides a method for detecting cancer using a tissue specimen. Specifically, for example, there is provided a method for detecting cancer in an organ or tissue having cancer, comprising: preparing a cell lysate from a region suspected to be cancer isolated from the organ or tissue; and evaluating a tactic behavior of a nematode for the cell lysate.
    Type: Application
    Filed: July 10, 2018
    Publication date: May 28, 2020
    Applicants: HIROTSU BIO SCIENCE INC., NANPUH HOSPITAL
    Inventors: Takaaki HIROTSU, Takuma YOSHINAGA
  • Publication number: 20190369084
    Abstract: The present invention provides a method for evaluating the taxic behavior of nematodes in response to an odor substance based on olfactory sense, and a dish and a behavior evaluation system to be used for the evaluation method. [Solution] Provided is a method for evaluating the taxic behavior of nematodes in response to odor of a test sample, the method including: a) providing a dish in which the test sample is arranged on the bottom surface, and nematodes are arranged in a region or a site of the bottom surface 1 cm to 3 cm away from the test sample; b) observing the arrangement of the nematodes on the bottom surface at 3 to 15 minutes after the later one of the test sample or the nematodes is arranged; and c) evaluating whether the nematodes show attraction behavior or avoidance behavior in response to the test sample, from the arrangement of the nematodes observed, and a dish or a taxic behavior evaluation system suitable for the method.
    Type: Application
    Filed: September 11, 2017
    Publication date: December 5, 2019
    Applicant: HIROTSU BIO SCIENCE INC.
    Inventors: Takaaki HIROTSU, Takayuki UOZUMI, Satoru KAIFUCHI
  • Publication number: 20170016906
    Abstract: A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
    Type: Application
    Filed: December 10, 2014
    Publication date: January 19, 2017
    Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Takaaki HIROTSU, Hideto SONODA