Patents by Inventor Takafumi Hosokawa

Takafumi Hosokawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8927588
    Abstract: To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: January 6, 2015
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Tsuyoshi Soneda, Hiroshi Takeshita, Yoshiko Kagoshima, Yuko Yamamoto, Takafumi Hosokawa, Toshiyuki Konosu, Nobuhisa Masuda, Takuya Uchida, Issei Achiwa, Junichi Kuroyanagi, Tetsunori Fujisawa, Aki Yokomizo, Tetsuji Noguchi
  • Publication number: 20140141369
    Abstract: A resin composed of a particular polymer, the particular polymer including a repeating unit containing a structure derived from a dehydroabietic acid, a specific structural unit, and a specific aromatic ring-containing structural unit in the main chain.
    Type: Application
    Filed: January 24, 2014
    Publication date: May 22, 2014
    Applicant: FUJIFILM Corporation
    Inventors: Takafumi HOSOKAWA, Kiyotaka FUKAGAWA
  • Publication number: 20140073622
    Abstract: To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 13, 2014
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Tsuyoshi Soneda, Hiroshi Takeshita, Yoshiko Kagoshima, Yuko Yamamoto, Takafumi Hosokawa, Toshiyuki Konosu, Nobuhisa Masuda, Takuya Uchida, Issei Achiwa, Junichi Kuroyanagi, Tetsunori Fujisawa, Aki Yokomizo, Tetsuji Noguchi
  • Patent number: 8586648
    Abstract: An aqueous colorant dispersion including a colorant (A), a polymer (B), and an aqueous liquid medium (I), wherein the polymer (B) is a copolymer including a hydrophilic structural unit and a hydrophobic structural unit, the content of the hydrophobic structural unit in the polymer (B) being more than 80% by mass but less than 100% by mass, the hydrophobic structural unit includes a hydrophobic structural unit (a) having an aromatic ring linked via a linking group to an atom included in the main chain of the polymer (B), the content of aromatic rings in the polymer (B) is 10% by mass or more but less than 20% by mass with respect to the mass of the polymer (B), the hydrophilic structural unit includes a hydrophilic structural unit (b) including an ionic group, and the polymer (B) includes a structural unit (c) different from the hydrophobic structural unit (a) and from the hydrophilic structural unit (b), the content of the structural unit (c) in the polymer (B) being more than 15% by mass but less than 90% by
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: November 19, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Takafumi Hosokawa, Misato Sasada, Naoya Shibata
  • Patent number: 8536197
    Abstract: An antibiotic compound having a novel mechanism of action, weak cytotoxicity, high solubility in water, effective in inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and having antibacterial activity.
    Type: Grant
    Filed: December 26, 2008
    Date of Patent: September 17, 2013
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Tsuyoshi Soneda, Hiroshi Takeshita, Yoshiko Kagoshima, Yuko Yamamoto, Takafumi Hosokawa, Toshiyuki Konosu, Nobuhisa Masuda, Takuya Uchida, Issei Achiwa, Junichi Kuroyanagi, Tetsunori Fujisawa, Aki Yokomizo, Tetsuji Noguchi
  • Publication number: 20130022907
    Abstract: Disclosed is a polymer which has a repeating unit containing a skeleton derived from dehydroabietic acid in the main chain, and has a glass transition point of 80° C. or lower.
    Type: Application
    Filed: March 30, 2011
    Publication date: January 24, 2013
    Applicant: FUJIFILM CORPORATION
    Inventors: Kiyotaka Fukagawa, Takafumi Hosokawa, Kozo Sato, Toshimitsu Sakuma
  • Patent number: 8178597
    Abstract: An aqueous inkjet recording ink including pigment particles coated with a water-insoluble resin, water, and a water-soluble organic solvent including at least one hydroxy group, wherein the water-insoluble resin has a salt-forming group and a structural unit which is derived from a methacrylate and has an aromatic ring linked via a linking group to an atom in the main chain of the water-insoluble resin, and the water-insoluble resin satisfies the condition that when the water-insoluble resin, an organic solvent, one equivalent of a neutralizing agent with respect to the salt-forming group, and water are mixed with a total content of the water-insoluble resin and the organic solvent being 35% by mass relative to the total mass of the mixture, an emulsion is formed without precipitation of the water-insoluble resin, and after the emulsion is allowed to stand for three hours, a transparent single phase is formed, or two separate phases are formed and at least an aqueous phase of the two phases is transparent.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: May 15, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Misato Sasada, Takafumi Hosokawa
  • Patent number: 8110616
    Abstract: An aqueous inkjet recording ink including at least a resin (A), a pigment (B) dispersed with the resin (A), a resin emulsion (C), and an aqueous liquid medium (D), wherein the resin (A) includes hydrophobic structural units (a) and hydrophilic structural units (b), the hydrophobic structural units (a) include a hydrophobic structural unit (a1) in an amount of 40% by mass or more of the resin (A), the hydrophobic structural unit (a1) having an aromatic ring indirectly linked to an atom for forming the main chain of the resin (A), and a hydrophobic structural unit (a2) in an amount of 15% by mass or more of the resin (A), the hydrophobic structural unit (a2) being derived from a C1 to C4 alkyl acrylate or methacrylate, the hydrophilic structural units (b) include a structural unit (b1) derived from an acrylic acid or a methacrylic acid, and the content of the hydrophilic structural units (b) is 15% by mass or less in the resin (A).
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: February 7, 2012
    Assignee: Fujifilm Corporation
    Inventors: Misato Sasada, Takafumi Hosokawa, Takahiro Kato
  • Patent number: 8053040
    Abstract: A composition comprising at least one liquid crystal compound, and at least one polymer is disclosed. The polymer comprises a constitutional unit represented by a following formula (A) and a constitutional unit derived from a monomer having a fluoroaliphatic group(s): wherein Mp represents a trivalent group constituting fully or partially a polymer main chain; L represents a single bond or a divalent linking group; and X represents a substituted or non-substituted aromatic condensed ring group.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: November 8, 2011
    Assignee: FUJIFILM Corporation
    Inventors: Yi Li, Hideyuki Nishikawa, Yuta Takahashi, Masataka Yoshizawa, Takafumi Hosokawa
  • Patent number: 8025936
    Abstract: The present invention aims to provide an optical compensation film that allows superior phase difference between a first optically anisotropic layer and a second optically anisotropic layer and excellent wavelength dispersibility in terms of front and inclined retardation of liquid crystal layers in liquid crystal cells, a polarizing plate containing the optical compensation film, and a liquid-crystal display device that can display superior images with less color change due to the polarizing plate. In order to attain the object, an optical compensation film etc. is provided that comprises at least a first optically anisotropic layer and a second optically anisotropic layer, wherein the first optically anisotropic layer satisfies at least one of the following Equations (i) to (iii): 1?Re1450)(0°)/Re1650)(0°)?1.25:??Equation (i) 1?Re1450)(40°)/Re1650)(40°)?1.25:??Equation (ii) 1?Re1450)(?40°)/Re1650)(?40°)?1.25:??Equation (iii).
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: September 27, 2011
    Assignee: FUJIFILM Corporation
    Inventors: Ryota Matsubara, Yuta Takahashi, Akira Ikeda, Masaru Yoshikawa, Takafumi Hosokawa, Michio Nagai, Makoto Takahashi
  • Patent number: 7998542
    Abstract: A composition comprising at least one liquid-crystal compound and a polymer having at least one group of the following formula: wherein Mp represents a trivalent linking group; L represents a single bond, or a divalent linking group; X represents a substituted or unsubstituted cyclic linking group; Y represents a single bond, or a divalent linking group; Z represents a substituted or unsubstituted cyclic group; n is 1 to 10.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: August 16, 2011
    Assignee: FUJIFILM Corporation
    Inventors: Yi Li, Masaru Yoshikawa, Makoto Takahashi, Takafumi Hosokawa
  • Patent number: 7989037
    Abstract: A composition comprising at least one liquid-crystal compound and a polymer having at least one group of the following formula (A) as the constitutive unit thereof: wherein Mp represents a trivalent linking group; L represents a single bond, or a bivalent linking group; X represents a substituted or unsubstituted functional group having a cyclic structure.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: August 2, 2011
    Assignee: FUJIFILM Corporation
    Inventors: Yi Li, Ichiro Nagata, Takafumi Hosokawa, Makoto Takahashi
  • Publication number: 20110076466
    Abstract: The present invention provides a toner composition for electrostatic photography, including a reactive compound A having a reactive group XA, and a reactive compound B having a reactive group XB that is capable of reacting with the reactive group XA and forming a bond, wherein the reactive compound B is capable of forming a three-dimensionally bonded structure by reacting with the reactive compound A, and wherein the toner composition includes the reactive compound A and the reactive compound B in a mutually isolated state. Preferably, the reactive compounds respectively have two or more reaction sites, and any one of the compounds has three or more reaction sites.
    Type: Application
    Filed: September 29, 2010
    Publication date: March 31, 2011
    Applicant: FUJIFILM CORPORATION
    Inventors: Hisashi OKAMURA, Kousaku YOSHIMURA, Takafumi HOSOKAWA
  • Publication number: 20100311966
    Abstract: An antibiotic compound having a novel mechanism of action, weak cytotoxicity, high solubility in water, effective in inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and having antibacterial activity.
    Type: Application
    Filed: December 26, 2008
    Publication date: December 9, 2010
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Tsuyoshi Soneda, Hiroshi Takeshita, Yoshiko Kagoshima, Yuko Yamamoto, Takafumi Hosokawa, Toshiyuki Konosu, Nobuhisa Masuda, Takuya Uchida, Issei Achiwa, Junichi Kuroyanagi, Tetsunori Fujisawa, Aki Yokomizo, Tetsuji Noguchi
  • Publication number: 20100216936
    Abstract: The present invention provides a water-based pigment composition including a pigment; a dispersant; and water, the dispersant including: a repeating unit including an ionic group; at least one of a repeating unit represented by Formula (2) or a repeating unit represented by Formula (3); and a repeating unit represented by Formula (1), a content of the repeating unit represented by Formula (1) being 20% by mass or more but less than 50% by mass with respect to a total amount of repeating units represented by Formulae (1) to (3), which is excellent in stability over time with finely dispersed pigment(s): wherein, in Formulae (1) to (3), R1 represents a hydrogen atom or a methyl group; R2 represents a hydrogen atom or a substituent; L1 represents a single bond or a divalent linkage group; and Ar represents a monovalent aromatic group.
    Type: Application
    Filed: January 28, 2010
    Publication date: August 26, 2010
    Inventors: Reiko INUSHIMA, Takafumi Hosokawa, Koji Yasuda, Naoya Shibata
  • Publication number: 20100078592
    Abstract: A composition comprising at least one liquid crystal compound, and at least one polymer is disclosed. The polymer comprises a constitutional unit represented by a following formula (A) and a constitutional unit derived from a monomer having a fluoroaliphatic group(s): wherein Mp represents a trivalent group constituting fully or partially a polymer main chain; L represents a single bond or a divalent linking group; and X represents a substituted or non-substituted aromatic condensed ring group.
    Type: Application
    Filed: March 13, 2008
    Publication date: April 1, 2010
    Applicant: FUJIFILM Corporation
    Inventors: Yi LI, Hideyuki Nishikawa, Yuta Takahashi, Masataka Yoshizawa, Takafumi Hosokawa
  • Publication number: 20100076148
    Abstract: The invention provides an ink composition containing at least: a pigment; one or more water-soluble organic solvent; a neutralizer; and water. At least a part of a surface of the pigment is coated with a copolymer containing at least a repeating unit represented by the following Formula (1) and a repeating unit having an ionic group. The one or more water-soluble organic solvents contains at least a water-soluble organic solvent having a solubility parameter value of 27.5 or less at a content of 90 weight % or more with respect to the total content of the one or more water-soluble organic solvents. In Formula (1), R1 represents a hydrogen atom or a methyl group; L1 represents a substituted or unsubstituted phenylene group; L2 represents a single bond or a divalent linkage group; and Ar represents a monovalent group derived from: a condensed aromatic ring having 8 or more carbon atoms; a hetero ring containing condensed aromatic rings; or two or more linked benzene rings.
    Type: Application
    Filed: September 17, 2009
    Publication date: March 25, 2010
    Applicant: FUJIFILM CORPORATION
    Inventors: Naoya SHIBATA, Takafumi HOSOKAWA, Yoshimitsu ARAI
  • Publication number: 20090221742
    Abstract: An aqueous colorant dispersion including a colorant (A), a polymer (B), and an aqueous liquid medium (I), wherein the polymer (B) is a copolymer including a hydrophilic structural unit and a hydrophobic structural unit, the content of the hydrophobic structural unit in the polymer (B) being more than 80% by mass but less than 100% by mass, the hydrophobic structural unit includes a hydrophobic structural unit (a) having an aromatic ring linked via a linking group to an atom included in the main chain of the polymer (B), the content of aromatic rings in the polymer (B) is 10% by mass or more but less than 20% by mass with respect to the mass of the polymer (B), the hydrophilic structural unit includes a hydrophilic structural unit (b) including an ionic group, and the polymer (B) includes a structural unit (c) different from the hydrophobic structural unit (a) and from the hydrophilic structural unit (b), the content of the structural unit (c) in the polymer (B) being more than 15% by mass but less than 90% by
    Type: Application
    Filed: February 24, 2009
    Publication date: September 3, 2009
    Applicant: FUJIFILM Corporation
    Inventors: Takafumi Hosokawa, Misato Sasada, Naoya Shibata
  • Publication number: 20090208652
    Abstract: An ink set for inkjet recording, including: an aqueous ink composition containing a pigment coated with a water-insoluble resin including a structural unit represented by the following formula (I), an organic solvent, a neutralizing agent, and water; and an aqueous liquid composition containing a component which aggregates the pigment in the aqueous ink composition when the aqueous liquid composition is mixed with the aqueous ink composition: wherein R1 represents a hydrogen atom or a methyl group, Ar represents an unsubstituted or substituted aromatic ring, and n represents an average number of repetition of 1 to 6.
    Type: Application
    Filed: February 13, 2009
    Publication date: August 20, 2009
    Applicant: FUJIFILM Corporation
    Inventors: Misato Sasada, Takafumi Hosokawa
  • Publication number: 20090203833
    Abstract: An aqueous inkjet recording ink including at least a resin (A), a pigment (B) dispersed with the resin (A), a resin emulsion (C), and an aqueous liquid medium (D), wherein the resin (A) includes hydrophobic structural units (a) and hydrophilic structural units (b), the hydrophobic structural units (a) include a hydrophobic structural unit (a1) in an amount of 40% by mass or more of the resin (A), the hydrophobic structural unit (a1) having an aromatic ring indirectly linked to an atom for forming the main chain of the resin (A), and a hydrophobic structural unit (a2) in an amount of 15% by mass or more of the resin (A), the hydrophobic structural unit (a2) being derived from a C1 to C4 alkyl acrylate or methacrylate, the hydrophilic structural units (b) include a structural unit (b1) derived from an acrylic acid or a methacrylic acid, and the content of the hydrophilic structural units (b) is 15% by mass or less in the resin (A).
    Type: Application
    Filed: February 9, 2009
    Publication date: August 13, 2009
    Applicant: FUJIFILM Corporation
    Inventors: Misato SASADA, Takafumi Hosokawa, Takahiro Kato