Abstract: To provide a method for evaluating or selecting an agent for reducing sensory irritation, which reduces sensory irritation caused by parabens, and an agent for reducing sensory irritation, which reduces sensory irritation caused by parabens. A method for evaluating or selecting an agent for reducing sensory irritation caused by parabens, comprising the following steps (1) to (3): (1) a step of contacting cells capable of expressing CES1 with a test substance; (2) a step of measuring expression of CES1 in the cells; (3) a step of evaluating a test substance which promotes expression of CES1 as an agent for reducing sensory irritation caused by parabens based on the results measured in (2).

Abstract: To provide a method for evaluating or selecting an agent for reducing sensory irritation, which reduces sensory irritation caused by parabens, and an agent for reducing sensory irritation, which reduces sensory irritation caused by parabens. A method for evaluating or selecting an agent for reducing sensory irritation caused by parabens, comprising the following steps (1) to (3): (1) a step of contacting cells capable of expressing CES1 with a test substance; (2) a step of measuring expression of CES1 in the cells; (3) a step of evaluating a test substance which promotes expression of CES1 as an agent for reducing sensory irritation caused by parabens based on the results measured in (2).

Abstract: This invention relates to skin pore tighteners each of which comprises, as an active ingredient, a compound represented by the following formula: R1—OG ??(1) wherein R1 represents an alkyl or alkenyl group having 8 to 32 carbon atoms, and OG represents a residual group obtained by removing a hydrogen atom from a hydroxyl group of a polyhydric alcohol, monosaccharide or oligosaccharide at least one hydroxyl group of which has been sulfated or phosphatized, or a salt thereof, and also to skin elasticity improvers each of which comprises, as an active ingredient, a glyceryl ether derivative represented by the following formula: wherein R1 represents the same group as defined above, and X1 and X2 each independently represents a hydrogen atom, —SO3OH or —PO(OH)2 with the proviso that X1 and X2 are not hydrogen atoms at the same time, or a salt thereof.

Abstract: This invention relates to skin pore tighteners each of which comprises, as an active ingredient, a compound represented by the following formula: R1—OG ??(1) wherein R1 represents an alkyl or alkenyl group having 8 to 32 carbon atoms, and OG represents a residual group obtained by removing a hydrogen atom from a hydroxyl group of a polyhydric alcohol, monosaccharide or oligosaccharide at least one hydroxyl group of which has been sulfated or phosphatized, or a salt thereof, and also to skin elasticity improvers each of which comprises, as an active ingredient, a glyceryl ether derivative represented by the following formula: wherein R1 represents the same group as defined above, and X1 and X2 each independently represents a hydrogen atom, —SO3OH or —PO(OH)2 with the proviso that X1 and X2 are not hydrogen atoms at the same time, or a salt thereof.

Abstract: This invention relates to skin pore tighteners each of which comprises, as an active ingredient, a compound represented by the following formula: